Analytical Methods for Quality and Quantity Control of Food Supplements, Containing Caffeine
International Journal of Nutrition and Food Sciences
Volume 4, Issue 1-1, January 2015, Pages: 14-17
Received: Nov. 5, 2014;
Accepted: Nov. 7, 2014;
Published: Nov. 12, 2014
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Papanov S., Medical University Plovdiv, Faculty of Pharmacy, Dept. of Botany and Pharmaceutical chemistry, Plovdiv, Bulgaria
Pankova S., Medical University Sofia , Faculty of Pharmacy, Dept. of Pharmaceutical chemistry, Sofia, Bulgaria
Ivanov K., Medical University Plovdiv, Faculty of Pharmacy, Dept. of Botany and Pharmaceutical chemistry, Plovdiv, Bulgaria
Ivanova S., Medical University Plovdiv, Faculty of Pharmacy, Dept. of Botany and Pharmaceutical chemistry, Plovdiv, Bulgaria
Doncheva D., Medical University Sofia , Faculty of Pharmacy, Dept. of Pharmaceutical chemistry, Sofia, Bulgaria
Pencheva I., Medical University Sofia , Faculty of Pharmacy, Dept. of Pharmaceutical chemistry, Sofia, Bulgaria
Many beverages such as soft drinks, coffee and tea contain the mild stimulant caffeine (C8H10N4O2). The caffeine content varies widely from about 100 μg/mL (100 ppm) in sodas to over 1000 μg/mL in certain types of coffee. For this reason the caffeine and the content in they need to be analyzed. A rapid and selective high-performance liquid chromatographic (HPLC) method is developed for the separation and determination of caffeine.
Analytical Methods for Quality and Quantity Control of Food Supplements, Containing Caffeine, International Journal of Nutrition and Food Sciences. Special Issue: Taurine and Caffeine Supplementation in Energy Food Drinks: Uses, Side Effects and Quality Control.
Vol. 4, No. 1-1,
2015, pp. 14-17.
Branislava Srdjenovic, Vukosava Djordjevic-Milic, Nevena Grujic, Rade Injac, and Zika Lepojevic. “Simultaneous HPLC Determination of Caffeine, Theobromine, and Theophylline in Food, Drinks, and Herbal Products” Journal of Chromatographic Science, Vol. 46,144-149, February 2008
J.B. Thomas, J.H. Yen, M.M. Schantz, B.J. Porter, and K.E. Sharpless. Determination of caffeine, theobromine, and theohylline in standard reference material 2384, baking chocolate, using reversedphase liquid chromatography. J. Agric. Food Chem. 52: 3259–63 (2004).
P.D. Tzanavaras and D.G. Themelis. Development and validation of a high-throughput high-performance liquid chromatography assay for the determination of caffeine in food samples using a monolithic column. Anal. Chim. Acta 581: 94–8 (2007).
D. Satinsky, I. Neto, P. Solich, H. Sklenárova, M. Conceição, B.S. Montenegro, and A.N. Araújo. Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets. J. Sep. Sci. 27:529–36 (2004).
M. Kartal. LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations. J. Pharm. Biomed. Anal. 26: 857–64 (2001).
F.L. Coco, F. Lanuzza, G. Micali, and G. Cappellano. Determination of theobromine, theophylline, and caffeine in by-products of cupuacu and cacao seeds by high-performance liquid chromatography. J. Chromatogr. Sci. 45: 273–5 (2007).
D.D. Rio, A.J. Stewart, W. Mullen, J. Burns, M.E.J. Lean, F. Brighenti and A. Crozier. HPLC–MSn analysis of phenolic compounds and purine alkaloids in green and black tea. J. Agric. Food Chem. 52: 2807–15 (2004).
C.I. Rodrigues, L. Marta, R. Maia, M. Miranda, M. Ribeirinho, and C. Maguas. Application of solid-phase extraction to brewed coffe caffeine and organic acid determination by UV–HPLC. J. Food Compost. Anal. 20: 440–8 (2007).
M.R. Brunetto, L. Gutierrez, Y. Delgado, M. Gallignani, A. Zambrano, A. Gomez, G. Ramos, and C. Romero.Determination of theobromine, theophylline and caffeine in cocoa samples by a high-performance liquid cromatografphic method with on-line sample cleanup in a switching-column system. Food Chem. 100: 459–67 (2007).
J.P. Naik. Imporoved high-performance liquid chromatography method to determine theobromine and caffeine in cocoa and cocoa products. J. Agric. Food Chem. 49: 6579–83 (2001).
A.R. Khanchi, M.K. Mahani, M. Hajihosseini, M.G. Maragheh, M. Chaloosi, and F. Bani. Simultaneous spectrophotometric determination of caffeine and theobromine in Iranian tea by artificial neural networks and its comparison with PLS. Food Chem.103:1062-8 (2007)
D.K. Sinhg and A. Sahu. Spectrophotometric determination of caffeine and theophylline in pure alkaloids and its application in pharmaceutical formulations. Anal. Biochem. 349: 176–80 (2006).
M. Arenda and G. Morlock. Simultaneous determination of caffeine, ergotamine and metamizol in solid pharmaceutical formulation by HPTLC–UV–FLD with mass confirmation by online HPTLC–ESI–MS. J. Chromatogr. Sci. 45: 251–5 (2007).
M.J. Ford, M.A. Deibel, B.A. Tomkins, and G.J. Van Berkel. Quantitative thin-layer chromatography–mass spectrometry analysis of caffeine using a surface sampling probe electrospray ionization tandem mass spectrometry system. Anal. Chem. 77:4385–9 (2005).
M. Aranda and G. Morlock. Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry. J. Chromatogr. A 1131: 253–60 (2006.)
V.V. Khasanov, K.A. Dychko, T.T. Kuryaeva, G.L. Ryzhova, and E.V. Maltseva. A new procedure for caffeine determination. Russ. J. Appl. Chem. 78: 1427–9 (2005).
S. Armenta, S. Garrigues, and M.Guardia. Solid-phase FT-Raman determination of caffeine in energy drinks. Anal. Chim. Acta 547: 197–203 (2005).
M.M. Paradkar and J. Irudayaraj. Rapid determination of caffeine content in soft drinks using FTIR–ATR spectroscopy. Food Chem. 78: 261–6 (2002).
M.S. Bispo, M.C.C. Veloso, H.L.C. Pinheiro, R.F.S. De Oliveira, J.O.N. Reis, and J.B. De Andrade. Simultaneouos determination of caffeine, theobromine, and theophylline by High performance liquid chromatography. J. Chromatogr. Sci. 40: 45–8 (2002).
United States Pharmacopoeia, 24th edition, NF 19, United States Pharmacopoeial Convention, Rockville, MD 2002.
International Conference on Harmonization, guideline Q2A, Text on validation of analytical procedures. Federal Register 1995, 60, 11260
International Conference on Harmonization, guideline Q2B, Validation of analytical procedures: methodology. Federal Register 1997, 62, 27463.
Y.V. Heyden, A. Nijhuis, J. Smeyers-Verbeke, B.G.M. Vandeginste, and D.L. Massart. Guidance for robustness/ruggedness tests in method validation. J. Pharm. Biomed. Anal. 24: 723–53 (2001).
L. Peikova, I. Pencheva, B. Tzvetkova, Chemical stability-indicating HPLC study of fixed-dosage combination containing metoprolol tartrate and hydrochlorothiazide, Journal of Chemical and Pharmaceutical Research, 2013, 5(7):132-140.
Analysis of drugs - derivatives of purine; Educational - methodical manual for students from Faculty of Pharmacy. State Educational Institution of Higher Professional Education Nizhny Novgorod State Medical Academy of the Russian Federal Agency of Health and Social Development. Nizhny Novgorod 2008.