International Journal of Nutrition and Food Sciences

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Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice

Received: 18 June 2017    Accepted: 05 July 2017    Published: 31 July 2017
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Abstract

The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.

DOI 10.11648/j.ijnfs.20170605.11
Published in International Journal of Nutrition and Food Sciences (Volume 6, Issue 5, September 2017)
Page(s) 187-193
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

In Vivo, Reactive Dyes, Levafix Blue CA, Levafix Amber CA, Toxicity

References
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Author Information
  • Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh

  • Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh

  • Department of Clinical Pathology, Dhaka Medical College, Dhaka, Bangladesh

  • Centre for Advanced Research in Sciences, University of Dhaka, Dhaka, Bangladesh

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    Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. (2017). Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. International Journal of Nutrition and Food Sciences, 6(5), 187-193. https://doi.org/10.11648/j.ijnfs.20170605.11

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    ACS Style

    Mohammad Farhadur Rahman; Nargish Jahan Ara; Mohammad Mesbah Uddin; Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int. J. Nutr. Food Sci. 2017, 6(5), 187-193. doi: 10.11648/j.ijnfs.20170605.11

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    AMA Style

    Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int J Nutr Food Sci. 2017;6(5):187-193. doi: 10.11648/j.ijnfs.20170605.11

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  • @article{10.11648/j.ijnfs.20170605.11,
      author = {Mohammad Farhadur Rahman and Nargish Jahan Ara and Mohammad Mesbah Uddin and Mohammad Zakir Sultan},
      title = {Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {6},
      number = {5},
      pages = {187-193},
      doi = {10.11648/j.ijnfs.20170605.11},
      url = {https://doi.org/10.11648/j.ijnfs.20170605.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijnfs.20170605.11},
      abstract = {The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice
    AU  - Mohammad Farhadur Rahman
    AU  - Nargish Jahan Ara
    AU  - Mohammad Mesbah Uddin
    AU  - Mohammad Zakir Sultan
    Y1  - 2017/07/31
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    DO  - 10.11648/j.ijnfs.20170605.11
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 187
    EP  - 193
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.20170605.11
    AB  - The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.
    VL  - 6
    IS  - 5
    ER  - 

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