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Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia

Received: 3 July 2014     Accepted: 16 July 2014     Published: 30 July 2014
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Abstract

Background: Among several trace elements, zinc is a micronutrient that has a very significant role in maintaining immune function. Studies investigating trace elements status in people living with HIV/AIDS are few in Ethiopia. Hence, the present study was undertaken to investigate the concentration of serum zinc among sex and age matched pre ART and on ART adults. Methods: A cross-sectional study was conducted among 150 people living with HIV/AIDS (75 pre -ART and 75 on -ART) adults. Concentrations of zinc from serum were measured using fully automated flame atomic absorption spectrophotometer. CD4+ T-cell count, CD8+ T-cell count, hemoglobin determination, and Body Mass Index (BMI) were performed to evaluate the clinical status of study participants. Results: Serum zinc deficiencies were observed in 46 (30.7%) study participants. In multivariate logistic regression analysis, pre-ART study participants were nearly four times more likely at risk of serum zinc deficiency than on-ART study participants (AOR=3.56, 95% CI=1.52 to 8.32). Similarly, the odds of being serum zinc deficient were three times more in undernourished study participants than nourished study participants (AOR=2.61, 95% CI=1.02 to 6.67). Conclusion: A relatively high percentage of study participants had serum zinc deficiency. Early evaluation of serum zinc deficiency and zinc supplementation along with anti-retroviral treatment should be considered for pre-ART and under nourished adult people living with HIV/AIDS.

Published in International Journal of Nutrition and Food Sciences (Volume 3, Issue 4)
DOI 10.11648/j.ijnfs.20140304.22
Page(s) 311-317
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Antiretroviral Therapy, Bahir Dar, HIV/AIDS, Serum Zinc Deficiency

References
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Cite This Article
  • APA Style

    Abera Ademasu, Bizuayehu Kerisew, Endalkachew Nibret, Abayneh Munshea, Melaku Adal. (2014). Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia. International Journal of Nutrition and Food Sciences, 3(4), 311-317. https://doi.org/10.11648/j.ijnfs.20140304.22

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    ACS Style

    Abera Ademasu; Bizuayehu Kerisew; Endalkachew Nibret; Abayneh Munshea; Melaku Adal. Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia. Int. J. Nutr. Food Sci. 2014, 3(4), 311-317. doi: 10.11648/j.ijnfs.20140304.22

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    AMA Style

    Abera Ademasu, Bizuayehu Kerisew, Endalkachew Nibret, Abayneh Munshea, Melaku Adal. Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia. Int J Nutr Food Sci. 2014;3(4):311-317. doi: 10.11648/j.ijnfs.20140304.22

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  • @article{10.11648/j.ijnfs.20140304.22,
      author = {Abera Ademasu and Bizuayehu Kerisew and Endalkachew Nibret and Abayneh Munshea and Melaku Adal},
      title = {Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {3},
      number = {4},
      pages = {311-317},
      doi = {10.11648/j.ijnfs.20140304.22},
      url = {https://doi.org/10.11648/j.ijnfs.20140304.22},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20140304.22},
      abstract = {Background: Among several trace elements, zinc is a micronutrient that has a very significant role in maintaining immune function. Studies investigating trace elements status in people living with HIV/AIDS are few in Ethiopia. Hence, the present study was undertaken to investigate the concentration of serum zinc among sex and age matched pre ART and on ART adults. Methods: A cross-sectional study was conducted among 150 people living with HIV/AIDS (75 pre -ART and 75 on -ART) adults. Concentrations of zinc from serum were measured using fully automated flame atomic absorption spectrophotometer. CD4+ T-cell count, CD8+ T-cell count, hemoglobin determination, and Body Mass Index (BMI) were performed to evaluate the clinical status of study participants. Results: Serum zinc deficiencies were observed in 46 (30.7%) study participants. In multivariate logistic regression analysis, pre-ART study participants were nearly four times more likely at risk of serum zinc deficiency than on-ART study participants (AOR=3.56, 95% CI=1.52 to 8.32). Similarly, the odds of being serum zinc deficient were three times more in undernourished study participants than nourished study participants (AOR=2.61, 95% CI=1.02 to 6.67). Conclusion: A relatively high percentage of study participants had serum zinc deficiency. Early evaluation of serum zinc deficiency and zinc supplementation along with anti-retroviral treatment should be considered for pre-ART and under nourished adult people living with HIV/AIDS.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Serum Zinc Deficiency and Associated Factors among Pre-ART and on-ART Adults at Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia
    AU  - Abera Ademasu
    AU  - Bizuayehu Kerisew
    AU  - Endalkachew Nibret
    AU  - Abayneh Munshea
    AU  - Melaku Adal
    Y1  - 2014/07/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ijnfs.20140304.22
    DO  - 10.11648/j.ijnfs.20140304.22
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 311
    EP  - 317
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.20140304.22
    AB  - Background: Among several trace elements, zinc is a micronutrient that has a very significant role in maintaining immune function. Studies investigating trace elements status in people living with HIV/AIDS are few in Ethiopia. Hence, the present study was undertaken to investigate the concentration of serum zinc among sex and age matched pre ART and on ART adults. Methods: A cross-sectional study was conducted among 150 people living with HIV/AIDS (75 pre -ART and 75 on -ART) adults. Concentrations of zinc from serum were measured using fully automated flame atomic absorption spectrophotometer. CD4+ T-cell count, CD8+ T-cell count, hemoglobin determination, and Body Mass Index (BMI) were performed to evaluate the clinical status of study participants. Results: Serum zinc deficiencies were observed in 46 (30.7%) study participants. In multivariate logistic regression analysis, pre-ART study participants were nearly four times more likely at risk of serum zinc deficiency than on-ART study participants (AOR=3.56, 95% CI=1.52 to 8.32). Similarly, the odds of being serum zinc deficient were three times more in undernourished study participants than nourished study participants (AOR=2.61, 95% CI=1.02 to 6.67). Conclusion: A relatively high percentage of study participants had serum zinc deficiency. Early evaluation of serum zinc deficiency and zinc supplementation along with anti-retroviral treatment should be considered for pre-ART and under nourished adult people living with HIV/AIDS.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Bahir Dar Health Science College, department of Medical laboratory Technology, Bahir Dar, Ethiopia

  • University of Bahir Dar, College of Science, department of Biology, Bahir Dar, Ethiopia

  • University of Bahir Dar, College of Science, department of Biology, Bahir Dar, Ethiopia

  • University of Bahir Dar, College of Science, department of Biology, Bahir Dar, Ethiopia

  • University of Bahir Dar, College of Science, department of Biology, Bahir Dar, Ethiopia

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