Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study
American Journal of Nursing Science
Volume 9, Issue 5, October 2020, Pages: 316-319
Received: Aug. 3, 2020;
Accepted: Aug. 14, 2020;
Published: Aug. 25, 2020
Views 168 Downloads 61
Fuxiang Luo, Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Jiaxin Wang, Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Yu Ding, Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Yangshen He, Department of Medicine, Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China
Chunli Wang, Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Tiantian Xiao, Department of Medicine, Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China
Follow on us
To investigate the effect of hydrocolloid dressings on reducing complications associated with azarcytidine injection. Methods: Twenty patients with myelodysplastic syndrome were included in the self-controlled study. The group settings were as follows: Experimental group A: Hydrocolloidal dressing was used alone after injection. Experimental group B: 50% magnesium sulfate topical. Experimental group C: blank control group. Pain, anxiety and depression scores, and complications of subcutaneous ecchymosis, subcutaneous induration, subcutaneous swelling and skin erythema were compared in each group. Results: Both the hydrocolloid dressings and 50% magnesium sulfate external application can reduce the local pain and reduce the occurrence of adverse emotions (A vs. C, P=0.000, P=0.000, P=0.000; B vs. C, P=0.000, P=0.092, P=0.044). Hydrocolloid dressings can effectively reduce the occurrence of skin ecchymosis, subcutaneous scleroma, subcutaneous swelling and skin erythema (X2=8.12, X2=8.12, X2=6.667, X2=3.956). P<0.01, P<0.01, P<0.022, P<0.047). Conclusion: The external application of hydrocolloid dressing can significantly reduce the occurrence of skin related complications and patients' adverse emotions after azarcytidine injection, with definite curative effect and strong application. It is an efficient and convenient nursing method.
Hydrocolloid Dressings, Azarcytidine, Complications
To cite this article
Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study, American Journal of Nursing Science.
Vol. 9, No. 5,
2020, pp. 316-319.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Montalban-Bravo G, Garcia-Manero G: Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management. American journal of hematology 2018, 93 (1): 129-147.
Vigil CE, Martin-Santos T, Garcia-Manero G. Safety and efficacy of azacitidine in myelodysplastic syndromes. Drug Des Devel Ther. 2010, 4: 221-229.
Shimoda-Komatsu Y, Mizukawa Y, Takayama N, Ohyama M. Cutaneous adverse events induced by azacitidine in myelodysplastic syndrome patients: Case reports and a lesson from published work review. J Dermatol. 2020; 47 (4): 363-368.
Roy C, Adam JP, Morin F, Lemieux-Blanchard É, Doucet S, Friedmann D, Belisle A, Charpentier D: Azacitidine-induced pyoderma gangrenosum at injection sites in a patient with myelodysplastic syndrome. Current oncology (Toronto, Ont) 2018, 25 (1): e103-e105.
Jurić Vukelić D, Jurić J: Hydrocolloid Dressing Application in the Treatment of Chronic Wounds and Relation to Quality of Life. Acta clinica Croatica 2017, 56 (3): 544-549.
Cortés OL, Salazar-Beltrán LD, Rojas-Castañeda YA, Alvarado-Muriel A, Serna-Restrepo A, Grinspun D: Use of Hydrocolloid Dressings in Preventing Pressure Ulcers in High-risk Patients: a Retrospective Cohort. Investigacion y educacion en enfermeria 2018, 36 (1): e11.
Bishopp A, Oakes A, Antoine-Pitterson P, Chakraborty B, Comer D, Mukherjee R. The Preventative Effect of Hydrocolloid Dressings on Nasal Bridge Pressure Ulceration in Acute Non-Invasive Ventilation. Ulster Med J. 2019; 88 (1): 17-20.
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama 2013, 310 (20): 2191-2194.
Mengiardi S, Tsakiris DA, Lampert ML, Hersberger KE: Drug use problems with self-injected low-molecular-weight heparins in primary care. European journal of clinical pharmacology 2011, 67 (2): 109-120.
Zhang X, Sun D, Jiang GC: Comparative efficacy of nine different dressings in healing diabetic foot ulcer: A Bayesian network analysis. Journal of diabetes 2019, 11 (6): 418-426.
Chamorro AM, Vidal Thomas MC, Mieras AS, Leiva A, Martínez MP, Hernández Yeste MMS: Multicenter randomized controlled trial comparing the effectiveness and safety of hydrocellular and hydrocolloid dressings for treatment of category II pressure ulcers in patients at primary and long-term care institutions. International journal of nursing studies 2019, 94: 179-185.
Zheng GH, Yang L, Chen HY, Chu JF, Mei L: Aloe vera for prevention and treatment of infusion phlebitis. The Cochrane database of systematic reviews 2014, 2014 (6): Cd009162.
Zis P, Daskalaki A, Bountouni I, Sykioti P, Varrassi G, Paladini A: Depression and chronic pain in the elderly: links and management challenges. Clinical interventions in aging 2017, 12: 709-720.
Francesko A, Petkova P, Tzanov T: Hydrogel Dressings for Advanced Wound Management. Curr Med Chem. 2018; 25 (41): 5782-5797.
Antonio Francesko, Petya Petkova and Tzanko Tzanov: Hydrogel Dressings for Advanced Wound Management. Current Medicinal Chemistry (2018) 25: 5782.