American Journal of Nursing Science

| Peer-Reviewed |

Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study

Received: 03 August 2020    Accepted: 14 August 2020    Published: 25 August 2020
Views:       Downloads:

Share This Article

Abstract

To investigate the effect of hydrocolloid dressings on reducing complications associated with azarcytidine injection. Methods: Twenty patients with myelodysplastic syndrome were included in the self-controlled study. The group settings were as follows: Experimental group A: Hydrocolloidal dressing was used alone after injection. Experimental group B: 50% magnesium sulfate topical. Experimental group C: blank control group. Pain, anxiety and depression scores, and complications of subcutaneous ecchymosis, subcutaneous induration, subcutaneous swelling and skin erythema were compared in each group. Results: Both the hydrocolloid dressings and 50% magnesium sulfate external application can reduce the local pain and reduce the occurrence of adverse emotions (A vs. C, P=0.000, P=0.000, P=0.000; B vs. C, P=0.000, P=0.092, P=0.044). Hydrocolloid dressings can effectively reduce the occurrence of skin ecchymosis, subcutaneous scleroma, subcutaneous swelling and skin erythema (X2=8.12, X2=8.12, X2=6.667, X2=3.956). P<0.01, P<0.01, P<0.022, P<0.047). Conclusion: The external application of hydrocolloid dressing can significantly reduce the occurrence of skin related complications and patients' adverse emotions after azarcytidine injection, with definite curative effect and strong application. It is an efficient and convenient nursing method.

DOI 10.11648/j.ajns.20200905.12
Published in American Journal of Nursing Science (Volume 9, Issue 5, October 2020)
Page(s) 316-319
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hydrocolloid Dressings, Azarcytidine, Complications

References
[1] Montalban-Bravo G, Garcia-Manero G: Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management. American journal of hematology 2018, 93 (1): 129-147.
[2] Vigil CE, Martin-Santos T, Garcia-Manero G. Safety and efficacy of azacitidine in myelodysplastic syndromes. Drug Des Devel Ther. 2010, 4: 221-229.
[3] Shimoda-Komatsu Y, Mizukawa Y, Takayama N, Ohyama M. Cutaneous adverse events induced by azacitidine in myelodysplastic syndrome patients: Case reports and a lesson from published work review. J Dermatol. 2020; 47 (4): 363-368.
[4] Roy C, Adam JP, Morin F, Lemieux-Blanchard É, Doucet S, Friedmann D, Belisle A, Charpentier D: Azacitidine-induced pyoderma gangrenosum at injection sites in a patient with myelodysplastic syndrome. Current oncology (Toronto, Ont) 2018, 25 (1): e103-e105.
[5] Jurić Vukelić D, Jurić J: Hydrocolloid Dressing Application in the Treatment of Chronic Wounds and Relation to Quality of Life. Acta clinica Croatica 2017, 56 (3): 544-549.
[6] Cortés OL, Salazar-Beltrán LD, Rojas-Castañeda YA, Alvarado-Muriel A, Serna-Restrepo A, Grinspun D: Use of Hydrocolloid Dressings in Preventing Pressure Ulcers in High-risk Patients: a Retrospective Cohort. Investigacion y educacion en enfermeria 2018, 36 (1): e11.
[7] Bishopp A, Oakes A, Antoine-Pitterson P, Chakraborty B, Comer D, Mukherjee R. The Preventative Effect of Hydrocolloid Dressings on Nasal Bridge Pressure Ulceration in Acute Non-Invasive Ventilation. Ulster Med J. 2019; 88 (1): 17-20.
[8] World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama 2013, 310 (20): 2191-2194.
[9] Mengiardi S, Tsakiris DA, Lampert ML, Hersberger KE: Drug use problems with self-injected low-molecular-weight heparins in primary care. European journal of clinical pharmacology 2011, 67 (2): 109-120.
[10] Zhang X, Sun D, Jiang GC: Comparative efficacy of nine different dressings in healing diabetic foot ulcer: A Bayesian network analysis. Journal of diabetes 2019, 11 (6): 418-426.
[11] Chamorro AM, Vidal Thomas MC, Mieras AS, Leiva A, Martínez MP, Hernández Yeste MMS: Multicenter randomized controlled trial comparing the effectiveness and safety of hydrocellular and hydrocolloid dressings for treatment of category II pressure ulcers in patients at primary and long-term care institutions. International journal of nursing studies 2019, 94: 179-185.
[12] Zheng GH, Yang L, Chen HY, Chu JF, Mei L: Aloe vera for prevention and treatment of infusion phlebitis. The Cochrane database of systematic reviews 2014, 2014 (6): Cd009162.
[13] Zis P, Daskalaki A, Bountouni I, Sykioti P, Varrassi G, Paladini A: Depression and chronic pain in the elderly: links and management challenges. Clinical interventions in aging 2017, 12: 709-720.
[14] Francesko A, Petkova P, Tzanov T: Hydrogel Dressings for Advanced Wound Management. Curr Med Chem. 2018; 25 (41): 5782-5797.
[15] Antonio Francesko, Petya Petkova and Tzanko Tzanov: Hydrogel Dressings for Advanced Wound Management. Current Medicinal Chemistry (2018) 25: 5782.
Author Information
  • Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China

  • Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China

  • Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China

  • Department of Medicine, Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China

  • Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China

  • Department of Medicine, Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China

Cite This Article
  • APA Style

    Fuxiang Luo, Jiaxin Wang, Yu Ding, Yangshen He, Chunli Wang, et al. (2020). Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study. American Journal of Nursing Science, 9(5), 316-319. https://doi.org/10.11648/j.ajns.20200905.12

    Copy | Download

    ACS Style

    Fuxiang Luo; Jiaxin Wang; Yu Ding; Yangshen He; Chunli Wang, et al. Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study. Am. J. Nurs. Sci. 2020, 9(5), 316-319. doi: 10.11648/j.ajns.20200905.12

    Copy | Download

    AMA Style

    Fuxiang Luo, Jiaxin Wang, Yu Ding, Yangshen He, Chunli Wang, et al. Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study. Am J Nurs Sci. 2020;9(5):316-319. doi: 10.11648/j.ajns.20200905.12

    Copy | Download

  • @article{10.11648/j.ajns.20200905.12,
      author = {Fuxiang Luo and Jiaxin Wang and Yu Ding and Yangshen He and Chunli Wang and Tiantian Xiao},
      title = {Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study},
      journal = {American Journal of Nursing Science},
      volume = {9},
      number = {5},
      pages = {316-319},
      doi = {10.11648/j.ajns.20200905.12},
      url = {https://doi.org/10.11648/j.ajns.20200905.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajns.20200905.12},
      abstract = {To investigate the effect of hydrocolloid dressings on reducing complications associated with azarcytidine injection. Methods: Twenty patients with myelodysplastic syndrome were included in the self-controlled study. The group settings were as follows: Experimental group A: Hydrocolloidal dressing was used alone after injection. Experimental group B: 50% magnesium sulfate topical. Experimental group C: blank control group. Pain, anxiety and depression scores, and complications of subcutaneous ecchymosis, subcutaneous induration, subcutaneous swelling and skin erythema were compared in each group. Results: Both the hydrocolloid dressings and 50% magnesium sulfate external application can reduce the local pain and reduce the occurrence of adverse emotions (A vs. C, P=0.000, P=0.000, P=0.000; B vs. C, P=0.000, P=0.092, P=0.044). Hydrocolloid dressings can effectively reduce the occurrence of skin ecchymosis, subcutaneous scleroma, subcutaneous swelling and skin erythema (X2=8.12, X2=8.12, X2=6.667, X2=3.956). P<0.01, P<0.01, P<0.022, P<0.047). Conclusion: The external application of hydrocolloid dressing can significantly reduce the occurrence of skin related complications and patients' adverse emotions after azarcytidine injection, with definite curative effect and strong application. It is an efficient and convenient nursing method.},
     year = {2020}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Hydrocolloidal Dressings Reduce Adverse Reactions Induced by Injection of Azarcytidine: A Clinical Observation Study
    AU  - Fuxiang Luo
    AU  - Jiaxin Wang
    AU  - Yu Ding
    AU  - Yangshen He
    AU  - Chunli Wang
    AU  - Tiantian Xiao
    Y1  - 2020/08/25
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajns.20200905.12
    DO  - 10.11648/j.ajns.20200905.12
    T2  - American Journal of Nursing Science
    JF  - American Journal of Nursing Science
    JO  - American Journal of Nursing Science
    SP  - 316
    EP  - 319
    PB  - Science Publishing Group
    SN  - 2328-5753
    UR  - https://doi.org/10.11648/j.ajns.20200905.12
    AB  - To investigate the effect of hydrocolloid dressings on reducing complications associated with azarcytidine injection. Methods: Twenty patients with myelodysplastic syndrome were included in the self-controlled study. The group settings were as follows: Experimental group A: Hydrocolloidal dressing was used alone after injection. Experimental group B: 50% magnesium sulfate topical. Experimental group C: blank control group. Pain, anxiety and depression scores, and complications of subcutaneous ecchymosis, subcutaneous induration, subcutaneous swelling and skin erythema were compared in each group. Results: Both the hydrocolloid dressings and 50% magnesium sulfate external application can reduce the local pain and reduce the occurrence of adverse emotions (A vs. C, P=0.000, P=0.000, P=0.000; B vs. C, P=0.000, P=0.092, P=0.044). Hydrocolloid dressings can effectively reduce the occurrence of skin ecchymosis, subcutaneous scleroma, subcutaneous swelling and skin erythema (X2=8.12, X2=8.12, X2=6.667, X2=3.956). P<0.01, P<0.01, P<0.022, P<0.047). Conclusion: The external application of hydrocolloid dressing can significantly reduce the occurrence of skin related complications and patients' adverse emotions after azarcytidine injection, with definite curative effect and strong application. It is an efficient and convenient nursing method.
    VL  - 9
    IS  - 5
    ER  - 

    Copy | Download

  • Sections