American Journal of Nursing Science

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Nursing Care of an Extremely Preterm Infant with Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report

Received: 17 June 2020    Accepted: 07 July 2020    Published: 17 July 2020
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Abstract

Sodium taurocholate cotransporting polypeptide (NTCP) is a protein encoded by the solute carrier family 10 member 1 gene and expressed in the basolateral membrane of the hepatocyte to uptake conjugated bile acids from the plasma. This study reported an extremely premature infant (EPI) with NTCP deficiency (NTCPD). The patient presented with jaundice, persistently elevated total bile acids, 25-(OH)-VitD deficiency, and cleft palate. Nursing care mainly focused on disease surveillance, jaundice care, nutrition, kangaroo mother care, and psychological care. In response to 5 months of the nursing care, the infant’s weight reached 3.324 kg, the jaundice was alleviated, and the infant gained the ability to suck milk. However, his TBA levels were abnormally elevated, and 25-(OH)-VitD was still deficient when the patient was discharged from hospital. The nurses taught the patient’s parents the importance of monitoring liver function and trace elements during a routine outpatient visit. Telephone follow-up 1 year later showed that the patient was in good health with no obvious clinical manifestations. This article reports our experiences in caring for an EPI with NTCPD. To the best of our knowledge, this is the first case report worldwide in NTCPD nursing care.

DOI 10.11648/j.ajns.20200904.26
Published in American Journal of Nursing Science (Volume 9, Issue 4, August 2020)
Page(s) 252-257
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Extremely Preterm Infant (EPI), Sodium Taurocholate Cotransporting Polypeptide (NTCP), Care, SLC10A1

References
[1] Pan W, Song IS, Shin HJ, et al. Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. Xenobiotica. 2011; 41 (6): 501-510.
[2] Anwer MS, Stieger B. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch. 2014; 466 (1): 77-89.
[3] Tan HJ, Deng M, Qiu JW, Wu JF, Song YZ. Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report. Front Pediatr. 2018; 6: 354.
[4] Vaz FM, Paulusma CC, Huidekoper H, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology. 2015; 61 (1): 260-267.
[5] Lin H, Qiu JW, Rauf YM, et al. Sodium Taurocholate Cotransporting Polypeptide (NTCP) Deficiency Hidden Behind Citrin Deficiency in Early Infancy: A Report of Three Cases. Front Genet. 2019; 10: 1108. Published 2019 Nov 7.
[6] Dong C, Zhang BP, Wang H, et al. Clinical and histopathologic features of sodium taurocholate cotransporting polypeptide deficiency in pediatric patients. Medicine (Baltimore). 2019; 98 (39): e17305.
[7] Chen R, Deng M, Rauf YM, et al. Intrahepatic Cholestasis of Pregnancy as a Clinical Manifestation of Sodium-Taurocholate Cotransporting Polypeptide Deficiency. Tohoku J Exp Med. 2019; 248 (1): 57-61.
[8] Li H, Deng M, Guo L, et al. Clinical and molecular characterization of four patients with NTCP deficiency from two unrelated families harboring the novel SLC10A1 variant c. 595A>C (p. Ser199Arg). Mol Med Rep. 2019; 20 (6): 4915-4924.
[9] Li, H., et al., [Clinical and genetic analysis of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency]. Zhongguo Dang Dai Er Ke Za Zhi, 2018. 20 (4): p. 279-284.
[10] Qiu JW, Deng M, Cheng Y, et al. Sodium taurocholate cotransporting polypeptide (NTCP) deficiency: Identification of a novel SLC10A1 mutation in two unrelated infants presenting with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia. Oncotarget. 2017; 8 (63): 106598-106607.
[11] Liu R, Chen C, Xia X, et al. Homozygous p. Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine. Sci Rep. 2017; 7 (1): 9214. Published 2017 Aug 23.
[12] Song, Y. Z. and M. Deng, [Sodium taurocholate cotransporting polypeptide deficiency manifesting as cholestatic jaundice in early infancy: a complicated case study]. Zhongguo Dang Dai Er Ke Za Zhi, 2017. 19 (3): p. 350-354.
[13] Van Herpe F, Waterham HR, Adams CJ, et al. NTCP deficiency and persistently raised bile salts: an adult case. J Inherit Metab Dis. 2017; 40 (3): 313-315.
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[17] Slijepcevic D, Kaufman C, Wichers CG, et al. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na (+) -taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015; 62 (1): 207-219.
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Author Information
  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Neonatal, The First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Nursing, The First Affiliated Hospital of Jinan University, Guangzhou, China

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  • APA Style

    Ni Zhang, Yuanzong Song, Weiju Chen, Meixue Chen, Lingli Cai, et al. (2020). Nursing Care of an Extremely Preterm Infant with Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report. American Journal of Nursing Science, 9(4), 252-257. https://doi.org/10.11648/j.ajns.20200904.26

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    ACS Style

    Ni Zhang; Yuanzong Song; Weiju Chen; Meixue Chen; Lingli Cai, et al. Nursing Care of an Extremely Preterm Infant with Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report. Am. J. Nurs. Sci. 2020, 9(4), 252-257. doi: 10.11648/j.ajns.20200904.26

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    AMA Style

    Ni Zhang, Yuanzong Song, Weiju Chen, Meixue Chen, Lingli Cai, et al. Nursing Care of an Extremely Preterm Infant with Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report. Am J Nurs Sci. 2020;9(4):252-257. doi: 10.11648/j.ajns.20200904.26

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  • @article{10.11648/j.ajns.20200904.26,
      author = {Ni Zhang and Yuanzong Song and Weiju Chen and Meixue Chen and Lingli Cai and Lijing Deng and Lilan He and Qingran Lin},
      title = {Nursing Care of an Extremely Preterm Infant with Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report},
      journal = {American Journal of Nursing Science},
      volume = {9},
      number = {4},
      pages = {252-257},
      doi = {10.11648/j.ajns.20200904.26},
      url = {https://doi.org/10.11648/j.ajns.20200904.26},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajns.20200904.26},
      abstract = {Sodium taurocholate cotransporting polypeptide (NTCP) is a protein encoded by the solute carrier family 10 member 1 gene and expressed in the basolateral membrane of the hepatocyte to uptake conjugated bile acids from the plasma. This study reported an extremely premature infant (EPI) with NTCP deficiency (NTCPD). The patient presented with jaundice, persistently elevated total bile acids, 25-(OH)-VitD deficiency, and cleft palate. Nursing care mainly focused on disease surveillance, jaundice care, nutrition, kangaroo mother care, and psychological care. In response to 5 months of the nursing care, the infant’s weight reached 3.324 kg, the jaundice was alleviated, and the infant gained the ability to suck milk. However, his TBA levels were abnormally elevated, and 25-(OH)-VitD was still deficient when the patient was discharged from hospital. The nurses taught the patient’s parents the importance of monitoring liver function and trace elements during a routine outpatient visit. Telephone follow-up 1 year later showed that the patient was in good health with no obvious clinical manifestations. This article reports our experiences in caring for an EPI with NTCPD. To the best of our knowledge, this is the first case report worldwide in NTCPD nursing care.},
     year = {2020}
    }
    

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    AU  - Ni Zhang
    AU  - Yuanzong Song
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    AB  - Sodium taurocholate cotransporting polypeptide (NTCP) is a protein encoded by the solute carrier family 10 member 1 gene and expressed in the basolateral membrane of the hepatocyte to uptake conjugated bile acids from the plasma. This study reported an extremely premature infant (EPI) with NTCP deficiency (NTCPD). The patient presented with jaundice, persistently elevated total bile acids, 25-(OH)-VitD deficiency, and cleft palate. Nursing care mainly focused on disease surveillance, jaundice care, nutrition, kangaroo mother care, and psychological care. In response to 5 months of the nursing care, the infant’s weight reached 3.324 kg, the jaundice was alleviated, and the infant gained the ability to suck milk. However, his TBA levels were abnormally elevated, and 25-(OH)-VitD was still deficient when the patient was discharged from hospital. The nurses taught the patient’s parents the importance of monitoring liver function and trace elements during a routine outpatient visit. Telephone follow-up 1 year later showed that the patient was in good health with no obvious clinical manifestations. This article reports our experiences in caring for an EPI with NTCPD. To the best of our knowledge, this is the first case report worldwide in NTCPD nursing care.
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