Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men

Esat Korgali; Mustafa Gökhan Gözel; Emin Yener Gültekin; Mustafa Zahir Bakici; Semih Ayan; Gökhan Gökçe

doi:doi:10.11648/j.cmr.20140302.13

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Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men

Esat Korgali, Mustafa Gökhan Gözel, Emin Yener Gültekin, Mustafa Zahir Bakici, Semih Ayan, Gökhan Gökçe

Published in Clinical Medicine Research (Volume 3, Issue 2)

Received: 22 January 2014 Accepted: Published: 10 March 2014

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Abstract

Background: Urinary tract infections (UTIs) in men are considered complicated, however few studies support this view. We compared the differences in the causative microorganism and their antimicrobial resistance between male and female patients presenting with an UTI. Methods: We evaluated the all microorganism isolated from the urine samples of patients which were admitted to outpatient clinics of our hospital during 2006 – 2011, which diagnosed with uncomplicated community acquired UTI. Results: Totally 8730 bacterial strains were isolated. Of these strains 5168 (59.2%) were isolated in women, whereas 3562 (40.8%) were isolated in men. Escherichia coli was the most frequently isolated microorganism (64.4%), followed by other enterobacteriaceae (15.1%) and enterococci (17.8%). However, the frequency of E. coli in men was significantly lower than in women, and frequency of other enterobacteriaceae and frequency of enterococci were higher than in women (49.4% versus 74.7%, 21.2% versus 10.8%, 24.7% versus 12.9%, respectively, p=0.001). The distribution of microorganism was evaluated according to age groups, similar results were observed in all age groups. In addition, E. coli, the most common strains for both sex. E. coli strains isolated in men were significantly less sensitive to ampicillin, ampicillin/sulbactam, cefuroxime, ceftriaxone, trimethoprim-sulphamethoxazole, gentamicin, ciprofloxacin, nitrofurantoin and fosfomycin than in women (p<0.05). Conclusion: The distribution of bacterial species isolated from urine culture of UTI is different in men. Even though E. coli is the most common strains in men as in women. In addition E. coli strains isolated in men were more resistant to antibiotics.

Published in	Clinical Medicine Research (Volume 3, Issue 2)
DOI	10.11648/j.cmr.20140302.13
Page(s)	21-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Urinary Tract Infection, E. coli, Antimicrobial Resistance, Community Acquired

References

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[2]	Griebling TL. Urologic diseases in America project: trends in resource use for urinary tract infections in men. J Urol. 2005;173: 1288-1294
[3]	Grabe M, Bjerklund-Johansen T.E, Botto H, Çek M,N aber K.G, Pickard R.S, Tenke P, Wagenlehner F, WulltB.Guidelines on Urological Infections. European Association of Urology 2013.
[4]	Wagenlehnera FM, Wulltb B, Perletti G. Antimicrobials in urogenital infections.International Journal of Antimicrobial Agents 2011; 38S 3– 10
[5]	Hummers-Pradier E, Ohse AM, Koch M, Heizmann WR, Kochen MM. Urinary tract infection in men. Int J ClinPharmacolTher. 2004;42:360-366.
[6]	Koeijers JJ, Kessels AG, Nys S, Bartelds A, Donker G, Stobberingh EE, VerbonA.Evaluation of the nitrite and leukocyte esterase activity tests for the diagnosis of acute symptomatic urinary tract infection in men. Clin Infect Dis. 2007;45:894-896.
[7]	Nicolle LE. Urinary tract infection: traditional pharmacologic therapies. Am J Med. 2002;113(Suppl 1A):35S-44S.
[8]	Rocha JL, Tuon FF, Johnson JR. Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance. Braz J Infect Dis 2012;16(2):115-121
[9]	Clinical and Laboratory Standards Institute (CLSI) (2010) Performance standards for antimicrobial susceptibility testing, 20th informational supplement. M100-S20. Wayne, PA: CLSI.
[10]	Ma KL, Wang CX. Analysis of the spectrum and antibiotic resistance of uropathogens in vitro:Results based on a retrospective study from a tertiary hospital. Am J Infect Control.2013 Jul;41(7):601-6.
[11]	Ulleryd P. Febrile urinary tract infection in men. Int J Antimicrob Agents 2003, 22(Suppl 2):89–93.
[12]	Linhares I, Raposo T, Rodrigues A, AlmeidaA: Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009). BMC Infectious Diseases 2013 13:19.
[13]	McGregor J C, Elman MR, Bearden TD, Smith DH: Sex- and age-specific trends in antibiotic resistance patterns of Escherichia coli urinary isolates from outpatients. BMC Family Practice 2013 14:25.
[14]	De Backer D, Christiaens T, Heytens S, De Sutter A, Stobberingh EE, VerschraegenG.Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval.JAntimicrobChemother. 2008 Aug;62(2):364-8
[15]	Karlowsky JA, Lagacé-Wiens PR, Simner PJ, DeCorby MR, Adam HJ, Walkty A, Hoban DJ, Zhanel GG. Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study. Antimicrob Agents Chemother. 2011 Jul;55(7):3169-75. doi: 10.1128/AAC.00066-11. Epub 2011 May 2
[16]	Maraki S, Mantadakis E, Michalidis L, Samonis G. Changing antibiotic susceptibilities of community-acquired uropathogens in Greece, 2005-2010. J MicrobiolImmunol Infect. 2012 Jul 11. [Epub ahead of print]
[17]	Zhanel GG, Hisanaga TL, Laing NM, DeCorby MR, Nichol KA, Palatnik LP, Johnson J, Noreddin A, Harding GK, Nicolle LE, Hoban DJ. Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents 2005, 26:380–388.
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[19]	Tseng MH, Lo WT, Lin WJ et al: Changing trend in antimicrobial resistance of pediatric uropathogens in Taiwan. PediatrInt, 2008; 50(6): 797–800

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Esat Korgali, Mustafa Gökhan Gözel, Emin Yener Gültekin, Mustafa Zahir Bakici, Semih Ayan, et al. (2014). Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clinical Medicine Research, 3(2), 21-24. https://doi.org/10.11648/j.cmr.20140302.13

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ACS Style

Esat Korgali; Mustafa Gökhan Gözel; Emin Yener Gültekin; Mustafa Zahir Bakici; Semih Ayan, et al. Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clin. Med. Res. 2014, 3(2), 21-24. doi: 10.11648/j.cmr.20140302.13

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AMA Style

Esat Korgali, Mustafa Gökhan Gözel, Emin Yener Gültekin, Mustafa Zahir Bakici, Semih Ayan, et al. Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clin Med Res. 2014;3(2):21-24. doi: 10.11648/j.cmr.20140302.13

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@article{10.11648/j.cmr.20140302.13,
  author = {Esat Korgali and Mustafa Gökhan Gözel and Emin Yener Gültekin and Mustafa Zahir Bakici and Semih Ayan and Gökhan Gökçe},
  title = {Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {21-24},
  doi = {10.11648/j.cmr.20140302.13},
  url = {https://doi.org/10.11648/j.cmr.20140302.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.13},
  abstract = {Background: Urinary tract infections (UTIs) in men are considered complicated, however few studies support this view. We compared the differences in the causative microorganism and their antimicrobial resistance between male and female patients presenting with an UTI. Methods: We evaluated the all microorganism isolated from the urine samples of patients which were admitted to outpatient clinics of our hospital during 2006 – 2011, which diagnosed with uncomplicated community acquired UTI. Results: Totally 8730 bacterial strains were isolated. Of these strains 5168 (59.2%) were isolated in women, whereas 3562 (40.8%) were isolated in men. Escherichia coli was the most frequently isolated microorganism (64.4%), followed by other enterobacteriaceae (15.1%) and enterococci (17.8%). However, the frequency of E. coli in men was significantly lower than in women, and frequency of other enterobacteriaceae and frequency of enterococci were higher than in women (49.4% versus 74.7%, 21.2% versus 10.8%, 24.7% versus 12.9%, respectively, p=0.001). The distribution of microorganism was evaluated according to age groups, similar results were observed in all age groups. In addition, E. coli, the most common strains for both sex. E. coli strains isolated in men were significantly less sensitive to ampicillin, ampicillin/sulbactam, cefuroxime, ceftriaxone, trimethoprim-sulphamethoxazole, gentamicin, ciprofloxacin, nitrofurantoin and fosfomycin than in women (p<0.05). Conclusion: The distribution of bacterial species isolated from urine culture of UTI is different in men. Even though E. coli is the most common strains in men as in women. In addition E. coli strains isolated in men were more resistant to antibiotics.},
 year = {2014}
}

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TY - JOUR
T1 - Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men
AU - Esat Korgali
AU - Mustafa Gökhan Gözel
AU - Emin Yener Gültekin
AU - Mustafa Zahir Bakici
AU - Semih Ayan
AU - Gökhan Gökçe
Y1 - 2014/03/10
PY - 2014
N1 - https://doi.org/10.11648/j.cmr.20140302.13
DO - 10.11648/j.cmr.20140302.13
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 21
EP - 24
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20140302.13
AB - Background: Urinary tract infections (UTIs) in men are considered complicated, however few studies support this view. We compared the differences in the causative microorganism and their antimicrobial resistance between male and female patients presenting with an UTI. Methods: We evaluated the all microorganism isolated from the urine samples of patients which were admitted to outpatient clinics of our hospital during 2006 – 2011, which diagnosed with uncomplicated community acquired UTI. Results: Totally 8730 bacterial strains were isolated. Of these strains 5168 (59.2%) were isolated in women, whereas 3562 (40.8%) were isolated in men. Escherichia coli was the most frequently isolated microorganism (64.4%), followed by other enterobacteriaceae (15.1%) and enterococci (17.8%). However, the frequency of E. coli in men was significantly lower than in women, and frequency of other enterobacteriaceae and frequency of enterococci were higher than in women (49.4% versus 74.7%, 21.2% versus 10.8%, 24.7% versus 12.9%, respectively, p=0.001). The distribution of microorganism was evaluated according to age groups, similar results were observed in all age groups. In addition, E. coli, the most common strains for both sex. E. coli strains isolated in men were significantly less sensitive to ampicillin, ampicillin/sulbactam, cefuroxime, ceftriaxone, trimethoprim-sulphamethoxazole, gentamicin, ciprofloxacin, nitrofurantoin and fosfomycin than in women (p<0.05). Conclusion: The distribution of bacterial species isolated from urine culture of UTI is different in men. Even though E. coli is the most common strains in men as in women. In addition E. coli strains isolated in men were more resistant to antibiotics.
VL - 3
IS - 2
ER -

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Author Information

Esat Korgali

Department of Urology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
Mustafa Gökhan Gözel
Emin Yener Gültekin

Department of Urology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
Mustafa Zahir Bakici

Department of Clinical Microbiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
Semih Ayan

Department of Urology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
Gökhan Gökçe

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APA Style

Esat Korgali, Mustafa Gökhan Gözel, Emin Yener Gültekin, Mustafa Zahir Bakici, Semih Ayan, et al. (2014). Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clinical Medicine Research, 3(2), 21-24. https://doi.org/10.11648/j.cmr.20140302.13

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ACS Style

Esat Korgali; Mustafa Gökhan Gözel; Emin Yener Gültekin; Mustafa Zahir Bakici; Semih Ayan, et al. Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clin. Med. Res. 2014, 3(2), 21-24. doi: 10.11648/j.cmr.20140302.13

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AMA Style

Esat Korgali, Mustafa Gökhan Gözel, Emin Yener Gültekin, Mustafa Zahir Bakici, Semih Ayan, et al. Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men. Clin Med Res. 2014;3(2):21-24. doi: 10.11648/j.cmr.20140302.13

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@article{10.11648/j.cmr.20140302.13,
  author = {Esat Korgali and Mustafa Gökhan Gözel and Emin Yener Gültekin and Mustafa Zahir Bakici and Semih Ayan and Gökhan Gökçe},
  title = {Distribution of Bacterial Species and Evaluation of their Antimicrobial Susceptibility Support a General Approach that Urinary Tract İnfections are Considered Complicated in Men},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {21-24},
  doi = {10.11648/j.cmr.20140302.13},
  url = {https://doi.org/10.11648/j.cmr.20140302.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.13},
  abstract = {Background: Urinary tract infections (UTIs) in men are considered complicated, however few studies support this view. We compared the differences in the causative microorganism and their antimicrobial resistance between male and female patients presenting with an UTI. Methods: We evaluated the all microorganism isolated from the urine samples of patients which were admitted to outpatient clinics of our hospital during 2006 – 2011, which diagnosed with uncomplicated community acquired UTI. Results: Totally 8730 bacterial strains were isolated. Of these strains 5168 (59.2%) were isolated in women, whereas 3562 (40.8%) were isolated in men. Escherichia coli was the most frequently isolated microorganism (64.4%), followed by other enterobacteriaceae (15.1%) and enterococci (17.8%). However, the frequency of E. coli in men was significantly lower than in women, and frequency of other enterobacteriaceae and frequency of enterococci were higher than in women (49.4% versus 74.7%, 21.2% versus 10.8%, 24.7% versus 12.9%, respectively, p=0.001). The distribution of microorganism was evaluated according to age groups, similar results were observed in all age groups. In addition, E. coli, the most common strains for both sex. E. coli strains isolated in men were significantly less sensitive to ampicillin, ampicillin/sulbactam, cefuroxime, ceftriaxone, trimethoprim-sulphamethoxazole, gentamicin, ciprofloxacin, nitrofurantoin and fosfomycin than in women (p<0.05). Conclusion: The distribution of bacterial species isolated from urine culture of UTI is different in men. Even though E. coli is the most common strains in men as in women. In addition E. coli strains isolated in men were more resistant to antibiotics.},
 year = {2014}
}

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