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Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)

Received: 04 January 2014    Accepted:     Published: 20 February 2014
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Abstract

Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=<0.0001) compared to non-carriers. In multivariate analysis, age (OR: 0.93, p=0.03), history of hepatitis (OR=8.18, p=0.005), unsafe injection with boiled syringe (OR: 3.41, p=0.03), and ALT (OR=1.03, p=0.002) were predictive factors of chronic HBsAg carriers. The model yielded an AUROC of 0.793±0.06. With a cut-off <0.125, the model allowed predicting chronic HBsAg carrier with a sensitivity and negative predictive value of 78.6 and 96.1% respectively. Among 28 chronic HBsAg carriers 22(78.6%) were correctly predicted and 6(21.4%) were false negative. With a cut-off >0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.

DOI 10.11648/j.cmr.20140302.11
Published in Clinical Medicine Research (Volume 3, Issue 2, March 2014)
Page(s) 12-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HBs Antigen, ALT, Hepatitis B, Sub-Saharan Africa

References
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Author Information
  • Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV); Service d’hépato-gastroentérologie, CHU de Yopougon

  • Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV); Service d’hépato-gastroentérologie, CHU de Cocody

  • Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV); Service d’hépato-gastroentérologie, CHU de Cocody

  • Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV); Service d’hépato-gastroentérologie, CHU de Yopougon

  • Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV); Service d’hépato-gastroentérologie, CHU de Cocody

  • Dispensaire du groupe de presse ??Fraternité Matin??

  • Service d’hépato-gastroentérologie, CHU de Cocody

  • Service d’hépato-gastroentérologie, CHU de Yopougon

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    Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. (2014). Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clinical Medicine Research, 3(2), 12-16. https://doi.org/10.11648/j.cmr.20140302.11

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    ACS Style

    Alassan K. Mahassadi; Emile Allah-Kouadio; Constant Assi; Fulgence M. Y. Bathaix; Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin. Med. Res. 2014, 3(2), 12-16. doi: 10.11648/j.cmr.20140302.11

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    AMA Style

    Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin Med Res. 2014;3(2):12-16. doi: 10.11648/j.cmr.20140302.11

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  • @article{10.11648/j.cmr.20140302.11,
      author = {Alassan K. Mahassadi and Emile Allah-Kouadio and Constant Assi and Fulgence M. Y. Bathaix and Ahmad Coulibaly and Hortense Hovi and Mathieu B. Camara and Thérèse Y. Ndri},
      title = {Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)},
      journal = {Clinical Medicine Research},
      volume = {3},
      number = {2},
      pages = {12-16},
      doi = {10.11648/j.cmr.20140302.11},
      url = {https://doi.org/10.11648/j.cmr.20140302.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cmr.20140302.11},
      abstract = {Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)
    AU  - Alassan K. Mahassadi
    AU  - Emile Allah-Kouadio
    AU  - Constant Assi
    AU  - Fulgence M. Y. Bathaix
    AU  - Ahmad Coulibaly
    AU  - Hortense Hovi
    AU  - Mathieu B. Camara
    AU  - Thérèse Y. Ndri
    Y1  - 2014/02/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.cmr.20140302.11
    DO  - 10.11648/j.cmr.20140302.11
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 12
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20140302.11
    AB  - Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.
    VL  - 3
    IS  - 2
    ER  - 

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