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Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride

Received: 23 December 2015    Accepted: 25 December 2015    Published: 18 June 2016
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Abstract

The study acylation reactions of dihydroquercetin apart from scientific interest has practical value. As a result of the reactions will form new organic compounds which may possess potential antioxidant, anti-inflammatory and cytotoxic activity [1]. Within this research studying of processes of acylation of a dihydroquercetin with use of benzoyl chloride and definition of chemical structure of new medicinal substances, as homogeneous samples of high degree of purity was the important and interesting point. One of the promising methods of studying the structure of drug substances is the method of IR spectroscopy. The method gives the chance to make an objective assessment of authenticity that allows to use actively it in the pharmaceutical analysis of many unknown connections [2-4]. It predetermined conduct of the compulsory registration of IR spectra for the original dihydroquercetin and synthesized on its basis of new substances with benzoyl chloride.

DOI 10.11648/j.cmr.s.2016050202.11
Published in Clinical Medicine Research (Volume 5, Issue 2-2, April 2016)

This article belongs to the Special Issue Development of Drugs: Computer Simulation, Chemical Synthesis and Clinical Trials

Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dihydroquercetin, benzoyl chloride, identification, infrared spectroscopy, the State Pharmacopoeia of Republic Kazakhstan, synthesis

References
[1] Boshkayeva Assyl, V. A. Georgiyants and L. O. Perekhoda Study of acyl substitution on docking properties of substituted dihydroquercetin as anti-inflammatory agents //Journal of Chemical and Pharmaceutical Research, 2014, 6 (4): 749-753.
[2] The State pharmacopoeia of the Republic of Kazakhstan. Issue 1. - Almaty: The publishing house "Zhibek Zholy", 2008. – P. 64-66.
[3] N. P. Sadchikova, A. P. Arzamastsev, A. V. Titova The method of near infrared spectroscopy in quality control of drugs (review) //Questions of Biological Medical and Pharmaceutical Chemistry. - 2010. - № 1. - Р. 16-20.
[4] L. Bellamy Infrared spectra of complex molecules. - M.: Peace, 1983. - 432 p.
[5] B. N. Tarasevich Basics of IR spectroscopy with Fourier transform. Preparation of samples in the infrared spectroscopy. - M., 2012. - 22 p.
[6] A. I. Slivkin, O. V. Trineeva, E. E. Logvinova and other. Atlas IR spectra of drugs. - Voronezh: The Publishing and printing center of Voronezh State University, 2013. - 172 p.
[7] A. S. Krylov, A. A. Vtyurin, Y. V. Gerasimov Data Processing Fourier Transform Infrared Spectroscopy: manual. - Krasnoyarsk Institute of Physics of the Russian Academy of Sciences, 2005. - 48 p.
[8] A. K. Boshkayeva, R. A. Omarova, M. K. Iskakova, A. M. Aktayeva, A. M. Toktabekova, M. R. Saurzhanova Evelopment and clinical laboratory researches of medicinal form "Maodent" //Actual Questions Of Development оf New Drugs:Abstracts оf XX International Scientific And Practical Conference Of Young Scientists And Student (April 22-23,2014). – Kh.: Publishing Office, 2014. – P. 23-24.
[9] A. К. Boshkayeva, Z. B. Sakipova, A. G. Kenjebayeva Prediction of biological activity and determining the reactivity of derivatives dihydroquercetin // Vestnik of KazNMU, - 2013. - № 5 (3). - P.36-38.
[10] A. К. Boshkayeva, H. M. Kamilov Application in the analysis of the reaction of formation of cyanine dyes // Pharmaceutical Journal. - Tashkent, 2009. - №2. - Р. 55-59.
Author Information
  • Module "Pharmacist-analyst", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • Module "Pharmacist-analyst", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • Module "Pharmacist-manager", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • Module "Pharmacist-technologist", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • Module "Pharmacist-technologist", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • Joint Course of pharmacology and pharmacy, Kazakh-Russian Medical University, Almaty, The Republic of Kazakhstan

  • Department of Internship of Dentistry, Institute of Stomatology, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

  • National Scientific Center for Natural Products, University of Mississippi, Oxford, The United States

  • Module "Pharmacist-toxicologist", Institute of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, The Republic of Kazakhstan

Cite This Article
  • APA Style

    А. К. Boshkayeva, R. A. Omarova, K. B. Zharimbetov, G. S. Ibadullayeva, E. M. Bissenbaev, et al. (2016). Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride. Clinical Medicine Research, 5(2-2), 1-7. https://doi.org/10.11648/j.cmr.s.2016050202.11

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    ACS Style

    А. К. Boshkayeva; R. A. Omarova; K. B. Zharimbetov; G. S. Ibadullayeva; E. M. Bissenbaev, et al. Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride. Clin. Med. Res. 2016, 5(2-2), 1-7. doi: 10.11648/j.cmr.s.2016050202.11

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    AMA Style

    А. К. Boshkayeva, R. A. Omarova, K. B. Zharimbetov, G. S. Ibadullayeva, E. M. Bissenbaev, et al. Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride. Clin Med Res. 2016;5(2-2):1-7. doi: 10.11648/j.cmr.s.2016050202.11

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  • @article{10.11648/j.cmr.s.2016050202.11,
      author = {А. К. Boshkayeva and R. A. Omarova and K. B. Zharimbetov and G. S. Ibadullayeva and E. M. Bissenbaev and K. K. Zhaldybaev and M. K. Iskakovа and Samir Anis Ross and A. S. Kozhamzharovа},
      title = {Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride},
      journal = {Clinical Medicine Research},
      volume = {5},
      number = {2-2},
      pages = {1-7},
      doi = {10.11648/j.cmr.s.2016050202.11},
      url = {https://doi.org/10.11648/j.cmr.s.2016050202.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cmr.s.2016050202.11},
      abstract = {The study acylation reactions of dihydroquercetin apart from scientific interest has practical value. As a result of the reactions will form new organic compounds which may possess potential antioxidant, anti-inflammatory and cytotoxic activity [1]. Within this research studying of processes of acylation of a dihydroquercetin with use of benzoyl chloride and definition of chemical structure of new medicinal substances, as homogeneous samples of high degree of purity was the important and interesting point. One of the promising methods of studying the structure of drug substances is the method of IR spectroscopy. The method gives the chance to make an objective assessment of authenticity that allows to use actively it in the pharmaceutical analysis of many unknown connections [2-4]. It predetermined conduct of the compulsory registration of IR spectra for the original dihydroquercetin and synthesized on its basis of new substances with benzoyl chloride.},
     year = {2016}
    }
    

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    T1  - Infrared Spectroscopic Study Dihydroquercetin and its New Substances with Benzoyl Chloride
    AU  - А. К. Boshkayeva
    AU  - R. A. Omarova
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    AU  - G. S. Ibadullayeva
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    AU  - K. K. Zhaldybaev
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    JF  - Clinical Medicine Research
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    AB  - The study acylation reactions of dihydroquercetin apart from scientific interest has practical value. As a result of the reactions will form new organic compounds which may possess potential antioxidant, anti-inflammatory and cytotoxic activity [1]. Within this research studying of processes of acylation of a dihydroquercetin with use of benzoyl chloride and definition of chemical structure of new medicinal substances, as homogeneous samples of high degree of purity was the important and interesting point. One of the promising methods of studying the structure of drug substances is the method of IR spectroscopy. The method gives the chance to make an objective assessment of authenticity that allows to use actively it in the pharmaceutical analysis of many unknown connections [2-4]. It predetermined conduct of the compulsory registration of IR spectra for the original dihydroquercetin and synthesized on its basis of new substances with benzoyl chloride.
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