Clinical Medicine Research

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Some Clinical Advances on Brugada Syndrome

Received: 03 July 2015    Accepted: 25 September 2015    Published: 12 October 2015
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Abstract

Brugada syndrome is an inherited arrhythmogenic disorder that exhibits ECG ST-segment elevation with a negetive T-wave in the right precordial leads (V1-V2), with normal heart structure,predisposing to VF and SCD. Its symptoms include syncope, nocturnal agonal respiration and cardiac arrest. Recently, reserches on Brugada syndrome had archived some advances, for examples, regarding to exposuring concealed Brugada 1 type ECG, besides pharmacological provocation, there are two orter methods: putting right precordial lead on the second intercostal space or Holter monitoring; early repolarization(J-wave) has important value in prognostic judgment of Brugada syndrome; radiofrequency catheter ablation was generally applied only in epicardium of RVOT in the past, while it has been applied in endocardium of RVOT today. Therefore, the endocardium of RVOT can be considered as an alternative site in the treatment of recurrent VF in Brugada syndrome.

DOI 10.11648/j.cmr.20150406.11
Published in Clinical Medicine Research (Volume 4, Issue 6, November 2015)
Page(s) 168-171
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Brugada Syndrome, Early Repolarization, Drug Provocation Test, Radiofrequency Catheter Ablation

References
[1] Brugada R, Campuzano O, Serguella-Brugada G, et al. Brugada syndrome [J]. Methodist Debakeg Cardiovasc, 2014, 10(1):25-28 PMID 24932359.
[2] Antzelevitch C, Nof E. Burgada syndrome: Recent advance and controversies [J]. Curr Cardiol Rep, 2008, 10(5):376-383 PMC 2614235.
[3] Cerrato N, Givstetto C, Gribaude E, et al. Prevalence of type 1 Brugada electrocardiographic pattern evaluated by twelve lead twenty-four-hour Holter monitoring[J].Am J Cardiol, 2015,115(1):52-56 PMID 25446872.
[4] Antzelevitch C, Brugada P, Brugada J, et al. Brugada syndrome: From cell to bedside [J]. Curr Probl Cardiol, 2005, 30(1):9-54 PMC 1975801.
[5] Li CL, Hu DY. Cardiac channellopathy induced syncope.(in Chinese)][J]. Advances in Cardiovascular Diseases, 2006, 27(4):407-412.
[6] Uzieblo-Zyczkowsk B, Gielerak G, Michalkiewicz D. Usefullness of patients history and noninvasive electrocardiographic patterns in prediction of ajmaline test results in patients with suspected Brugada syndrome [J]. Arch Med Sci, 2014, 10(5):899-912 PMC 4223127.
[7] Conte G, Sieira J, Sarkozy A, et al. Life-threatening ventricular arrhythmias during ajmaline challenge in patients with Brugada syndrome: incidencs, clinical feature and prognosis[J].Heart Rhythm, 2013,10(12):1869-1874 PMID 24055942.
[8] Dubner S, Azocar D, Gallino S, et al. Single oral flecainide does to unmask type 1 Brugada syndrome electrocardiographic pattern [J]. Ann Noninvasive Electrocardiol, 2013, 18(3):256-261 PMID 23714084.
[9] Calvo D, Rubin JM, Perez D, et al. Time-dependent response to provocative testing with flecainide in the diagnosis of Brugada syndrome [J]. Herat Rhythm, 2015, 12(2):350-357 PMID 25460174.
[10] Anselm DD, Evans JM, Baranchuk A, et al. Brugada phenocopy: A new electrocardiogram phenomenon [J]. World J Cardiol, 2014, 6(3):81-86 PMID 24669289.
[11] Oreto G, Corrado D, Delise P, et al. Doulbts of the cardiologist regarding an electrocardiogram presenting QRS V1-V2 complexes with positive terminal wave and ST segment elevation. Conensus conference promote by the Italian Cardiology Society [J].G Ital Cardiol (Rome), 2010, 11(Suppl 2):3S-22S PMID 21361048.
[12] Antzelevitch C. J wave syndrome: Molecular and cellular mechanismus [J].J Electrocardiol, 2013, 46(6): 510-518 PMID 24011992.
[13] Razus C, Flona. M, Moga VD, et al.Early repolarization syndrome: Electroar diographic sign and clinical implications [J].Ann Noninvasive Electrocardiol, 2014, 14(1):15-22 PMID 24118137.
[14] Antzelevitch C, Yan GX. J wave syndrome [J].Heart Rhythm, 2010, 7(4): 549-558 PMID 20153265.
[15] Levy S, Sbraqia P. ECG repolarization syndrome abnormalitics (J wave syndrome) and idiopthis ventricular fibrillation [J].J Interv Card Electrophysiol, 2011, 32(3): 181-186 PMID 21833514.
[16] Mizusawa Y, Bezzina CR. Early repolarization pattern: Its ECG characteristic, arrhythmogeneity and heritability [J].J Interv Card Electrophysiol, 2014, 39(3): 185-192 PMID 24532112.
[17] Kawata H, Morita H, Yamada Y, et al. Prognostic significance of early repolarization in inferiolateral leads in Brugada patients with documented ventricular fibrillation: A novel risk factor for Brugada syndrome with ventricular fibrillation [J]. Heart Rhythm, 2013, 10(8):1161-1168 PMID 23587501.
[18] Takaqi M, Aonumak K, Sakiquchi Y, et al. The prognostic value of early repolarization (J wave) and ST-segment morphology after J wave in Brugada syndrome multicenter study in Japan [J].Heart Rhythm, 2013, 10(4): 533-539 PMID 23274366.
[19] Szeplaki G, Ozcan EE, Qsztheimer I, et al. Ablation of the epicardial substrate in the right ventricular outflow tract in a patient with Brugada syndrome refusing implantable cardioverter defibrillator therapy[J].Can J Cardiol,2014,30(10):1249 eg-1249 en PMID 25262866.
[20] Conte G, Sieira J, Ciconte G, et al. Implantable cardioverter-defibrillator therapy in Brugada syndrome: A 20 year single-center experience [J].J Am Coll Cardiol, 2015, 65(9): 879-888 PMID 25744001.
[21] Hsiao PY, Tien HC, Lo CP, et al. Gene mutations in cardiac arrhythmias: A review of recent evidence in ion channelopathies [J]. Appl Clin Genet, 2013, 6:1-13 PMID 23837003.
[22] Nademanee K, Veerakul G, Chandanamattha P, et al. Prevention of ventricular fibrillation episodes in Brugada syndrome by Catheter ablation over the anterior right ventricular outflow tract epicardium [J].Circulation, 2011, 123(12): 1270-1279 PMID 21463098.
[23] Sunsaneewitayakul B, Yao Y, Thamaree S, et al. Endocardial mapping and catheter ablation for ventricular fibrillation in Brugada syndrome [J]. J Cardiovasc Electrophysiol, 2012, 23(Suppl 1):S10-S16 PMID 22988965.
[24] Fish JM, Welchons DR, Kim Y, et al. Dimethyl lithospermate B: An extract of danshen surpresses arrhythmgenesis associated with the Brugada syndrome [J]. Circulation, 2006, 113:1393-1400 PMID 16534004.
Author Information
  • Clinical Department, Nanchang City Institute of Medical Science, Nanchang, China

  • Literature Department, Nanchang City Institute of Medical Science, Nanchang, China

  • Clinical Department, Nanchang City Institute of Medical Science, Nanchang, China

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    Hu Kangxin, Pan Jie, Yao Wenliang. (2015). Some Clinical Advances on Brugada Syndrome. Clinical Medicine Research, 4(6), 168-171. https://doi.org/10.11648/j.cmr.20150406.11

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    ACS Style

    Hu Kangxin; Pan Jie; Yao Wenliang. Some Clinical Advances on Brugada Syndrome. Clin. Med. Res. 2015, 4(6), 168-171. doi: 10.11648/j.cmr.20150406.11

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    AMA Style

    Hu Kangxin, Pan Jie, Yao Wenliang. Some Clinical Advances on Brugada Syndrome. Clin Med Res. 2015;4(6):168-171. doi: 10.11648/j.cmr.20150406.11

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  • @article{10.11648/j.cmr.20150406.11,
      author = {Hu Kangxin and Pan Jie and Yao Wenliang},
      title = {Some Clinical Advances on Brugada Syndrome},
      journal = {Clinical Medicine Research},
      volume = {4},
      number = {6},
      pages = {168-171},
      doi = {10.11648/j.cmr.20150406.11},
      url = {https://doi.org/10.11648/j.cmr.20150406.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cmr.20150406.11},
      abstract = {Brugada syndrome is an inherited arrhythmogenic disorder that exhibits ECG ST-segment elevation with a negetive T-wave in the right precordial leads (V1-V2), with normal heart structure,predisposing to VF and SCD. Its symptoms include syncope, nocturnal agonal respiration and cardiac arrest. Recently, reserches on Brugada syndrome had archived some advances, for examples, regarding to exposuring concealed Brugada 1 type ECG, besides pharmacological provocation, there are two orter methods: putting right precordial lead on the second intercostal space or Holter monitoring; early repolarization(J-wave) has important value in prognostic judgment of Brugada syndrome; radiofrequency catheter ablation was generally applied only in epicardium of RVOT in the past, while it has been applied in endocardium of RVOT today. Therefore, the endocardium of RVOT can be considered as an alternative site in the treatment of recurrent VF in Brugada syndrome.},
     year = {2015}
    }
    

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    T1  - Some Clinical Advances on Brugada Syndrome
    AU  - Hu Kangxin
    AU  - Pan Jie
    AU  - Yao Wenliang
    Y1  - 2015/10/12
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    JO  - Clinical Medicine Research
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    AB  - Brugada syndrome is an inherited arrhythmogenic disorder that exhibits ECG ST-segment elevation with a negetive T-wave in the right precordial leads (V1-V2), with normal heart structure,predisposing to VF and SCD. Its symptoms include syncope, nocturnal agonal respiration and cardiac arrest. Recently, reserches on Brugada syndrome had archived some advances, for examples, regarding to exposuring concealed Brugada 1 type ECG, besides pharmacological provocation, there are two orter methods: putting right precordial lead on the second intercostal space or Holter monitoring; early repolarization(J-wave) has important value in prognostic judgment of Brugada syndrome; radiofrequency catheter ablation was generally applied only in epicardium of RVOT in the past, while it has been applied in endocardium of RVOT today. Therefore, the endocardium of RVOT can be considered as an alternative site in the treatment of recurrent VF in Brugada syndrome.
    VL  - 4
    IS  - 6
    ER  - 

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