Vitamin D Level in Pregnant Women Depends on Age and Weight Before and During Pregnancy
Clinical Medicine Research
Volume 9, Issue 3, May 2020, Pages: 54-58
Received: Apr. 25, 2020;
Accepted: May 25, 2020;
Published: Jun. 4, 2020
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Anna-Maria Borissovа, Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria
Boyana Trifonova, Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria
Lilia Dakovska, Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria
Evgenia Mihailova, Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria
Mircho Vukov, Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria
The AIM of our study was to evaluate the association between vitamin D levels and age, body weight before pregnancy and during the screening and the term of pregnancy. MATERIALS AND METHODS: We investigated 547 unselected pregnant Bulgarian women, mean age 30 ± 5 years, median 30 years (18-47 years). The distribution of pregnant women according to their age is as follows: 18-22 y – 33 (6%), 23-27 y – 115 (21%), 28-33 y – 219 (40%), 33-37 y – 128 (23.4%), 38-42 y – 46 (8%), 43-47 y – 6 (1.1%). The allocation according to trimesters of pregnancy was: first trimester - 111 (20.3%), second trimester - 275 (50.4%), and third trimester - 161 (29.3%). In the current study we introduced four categories of 25 (OH) D - <10, 10-20, 20-30 and >30 ng/mL. We evaluated the body weight prior to conception and during pregnancy. The peripheral levels of 25 (OH) D were investigated using a standard assay in a central laboratory on the day of the sampling. RESULTS: We found significant correlation between vitamin D levels and age (P < 0.0001), negative correlation with the BMI prior to conception (P < 0.001) and at the time of the screening (P < 0.0001), but no significant differences among the three trimesters concerning vitamin D levels. CONCLUSIONS: The levels of vitamin D among pregnant Bulgarian women are within the span of mild insufficiency, probably due to the normal BMI before and during the pregnancy. We noticed that with the increase of age, the more mature pregnant women have more responsible behavior and follow the advice of their obstetrician/gynecologist.
Vitamin D Level in Pregnant Women Depends on Age and Weight Before and During Pregnancy, Clinical Medicine Research.
Vol. 9, No. 3,
2020, pp. 54-58.
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