Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases
The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.
Juan Carlos Paredes-Palma,
Sandra Vanesa Patzi-Vargas,
Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases, Clinical Medicine Research. Special Issue: Globalization and Advances on Non-Communicable Chronic Diseases.
Vol. 8, No. 6,
2019, pp. 137-143.
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