Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis
Clinical Medicine Research
Volume 8, Issue 5, September 2019, Pages: 93-100
Received: Aug. 10, 2019; Accepted: Sep. 10, 2019; Published: Sep. 30, 2019
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Authors
Daniel Lopez-Hernandez, Sub-Directorate of Prevention and Health Protection, Institute of Security and Social Services of State Workers, Mexico City, Mexico; Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico
Nadhyieli Orozco-Campos, Sub-Directorate of Prevention and Health Protection, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Leticia Brito-Aranda, Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico
Maria de la Luz Lopez-Hernandez, Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico
Aurora Bautista-Marquez, Sub-Directorate of Prevention and Health Protection, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Vesta Richardson, Sub-Directorate of Prevention and Health Protection, Institute of Security and Social Services of State Workers, Mexico City, Mexico
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Abstract
There has been a limited evaluation of the efficacy of administered vitamin-D3 and bisphosphonate in a single pill (once-weekly) on changes of Bone Mineral Density (BMD), speciality in elderly people. To evaluate the changes in BMD, using Risedronate and vitamin D3, in patients from the first level of primary care after a period of more than 2 years of follow-up. An observational and retrospective cohort study, in a non-controlled, real-life setting nested to a database was designed. Records of participants between March-04-2008 and June-27-2012. Mexican patients from 21 Clinics of Family Medicine. The database is characterized by all patients received Risedronate (35 mg) and vitamin-D3 (2800 IU) combined in a single pill, administered once-weekly. BMD was determined in the distal portion of the radius bone using an Omnisense-7000S bone densitometer. The Kaplan-Meier method was used to estimate cumulative probabilities. Hazard ratios (HRs) were estimated using Cox-proportional hazard-models. A total of 14,721 women were included. The mean time of treatment was 27.06 months (interquartile-range=26.00-29.00); the crude HR in patients with osteoporosis was 2.483 (95%CI 1.806-3.414) times higher than their counterparts with osteopenia. In relation to age, the increase in BMD was 26% higher (HR=0.739; 95%CI 0.712-0.766) in patients with 60 or more age than their counterparts aged ≤59 years. The duration of treatment with risedronate/vitamin D3 once-weekly depends on the target population and need strict monitoring of BMD particularly for those patients who have a treatment for more of 18 months due to the risk of decreased BMD.
Keywords
Risedronate (35 mg) and Vitamin D3 (2800 IU), Retrospective Cohort Study, Bone Mineral Density, Cox Proportional Hazard Models
To cite this article
Daniel Lopez-Hernandez, Nadhyieli Orozco-Campos, Leticia Brito-Aranda, Maria de la Luz Lopez-Hernandez, Aurora Bautista-Marquez, Vesta Richardson, Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis, Clinical Medicine Research. Special Issue: Globalization and Advances on Non-Communicable Chronic Diseases. Vol. 8, No. 5, 2019, pp. 93-100. doi: 10.11648/j.cmr.20190805.11
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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