Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)
Clinical Medicine Research
Volume 8, Issue 4, July 2019, Pages: 77-84
Received: Jul. 26, 2019; Accepted: Aug. 22, 2019; Published: Sep. 10, 2019
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Authors
Sayed Mohammed Hamouda, Department of Microbiology, Animal Health Research Institute, Agriculture Research Center, Assiut, Egypt
Heba Mohammed Mohammed Kuraa, Vet. Surgery, General Organization of Vet. Med, Assiut Directory, Egypt
Mahmoud Abed Zaher Abd El-Samieh, Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
Magda Mahmoud Ali, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
Haroun Ali Youssef, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
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Abstract
Non-healed wounds are a significant problem in the healthcare system of the distal portions of the limbs. Nine types of honey were tested for wound healing judged by clinical gross healing parameters, rate of wound contraction and sings of epithelization histopathologically. Rounded full thickness skin wounds (1.5cm diameter) were performed at the distal portion of limbs. The wounds were infected by standard dose of MRSA (methicillin resistance Staph. aureus) for 72 hours. The tested types of honey were tested for MIC & MBC against clinical MRSA strain. Different types of honey were applied unprocessed as daily topical wound dressing for the infected wounds. Propolis with black seed honey followed by Hadramout sidr honey, then Egyptian sidr honey proved to have the most antimicrobial activity. Clinical healing appearance revealed that propolis with black seed honey, Egyptian sidr honey and Hadramout sidr honey showed the most preferable clinical parameters (gross appearance and rate of wound contraction), and histopathologically achieved the best healing epithelization 28 days after treatment. The study concluded that among different nine honey types retailed in Egyptian markets, all tested honey types had wound healing activities but with different potencies. Propolis with black seed, Egyptian sidr honey and Hadramout honey were the most potent with highly significance differences (P < 0.01), since achieving the most wound contraction rates, rapid epithelization post 28 days rather than the least MICs & MBCs values. While the marjoram and clover honey were the least effective.
Keywords
Wound Healing, Honey Apitherapy, MIC & MBC of Honeys, Histopathology of Wound Healing
To cite this article
Sayed Mohammed Hamouda, Heba Mohammed Mohammed Kuraa, Mahmoud Abed Zaher Abd El-Samieh, Magda Mahmoud Ali, Haroun Ali Youssef, Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys), Clinical Medicine Research. Vol. 8, No. 4, 2019, pp. 77-84. doi: 10.11648/j.cmr.20190804.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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