Classification of Incident Types of Hematologic Malignancy Using Discriminant Analysis at Kinshasa University Clinics, DR Congo
Clinical Medicine Research
Volume 8, Issue 3, May 2019, Pages: 56-62
Received: Nov. 29, 2018; Accepted: Jan. 29, 2019; Published: Jul. 22, 2019
Views 115      Downloads 23
Authors
Mireille Solange Nkanga Nganga, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Benjamin Longo-Mbenza, Faculty of Medicine, Department of Research, Walter Sisulu University, Mthatha, South Africa
Fons Verdonck, UZ Gasthuisberg/ KU Leuven, Department of Education, Leuven, Belgium
Branly Kilola Mbunga, Public Health School, Department of Nutrition, University of Kinshasa, Faculty of Medicine, Kinshasa, DR Congo
Aimé Tshiyamu Mbaya, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Christian Lueme Lokatola, Faculty of Medicine, Department of Research, Walter Sisulu University, Mthatha, South Africa
Teke Apalata, Faculty of Medicine, Department of Research, Walter Sisulu University, Mthatha, South Africa
Jean-Marie Ntumba Kayembe, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Georges Lelo Mvumbi, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Blaise Matondo Ma Nzambi Sumbu, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Alain Nzonzila Nganga, Saint Joseph Hospital, Department of Reanimation, Kinshasa, DR Congo
David Muballe, Faculty of Medicine, Department of Research, Walter Sisulu University, Mthatha, South Africa
Cecile Roth Laure Miakassissa Mapapa, Service of Pediatry, Department of Neonatology, University Hospital Center of Brazzaville, Brazzaville, Republic of Congo
Paul Roger Kazadi Beia, OVD Hospital Centre, Department of Health, Kinshasa, DR Congo
Aurore Cecilia Orphée Mbombo Beia, Faculty of Medicine, Biomedical School of Medicine, University of Kinshasa, Kinshasa, DR Congo
Donatien Nzongola Nkasu Kayembe, Faculty of Medicine, Department of Medical Biology, University of Kinshasa, Kinshasa, DR Congo
Article Tools
Follow on us
Abstract
The objective of this study was to identify important biomarker differences between absence of HM and expected morphopathologic types of HM. A retrospective analysis study of adult patients aged ≥ 20 years was managed by cytologic aspects such as normal myelogram vs. HM types between 2009 and 2015. Out of 105 patients, 63 (60%) experienced incident HM while 42, 14, 18, 10, 10, 6, and 5 patients had normal myelogram, multiple myeloma (MM), acute myeloid leukaemia (AML), myelodysplastic syndromes (MDS), chronic myeloid leukaemia (CML), acute myeloid leukaemia (CLL) and acute lymphoid leukaemia (ALL), respectively. In Discriminant Analysis (DA), only levels of transfusion, Hb, and WCC discriminated significantly (Wilks lambda =0.159; P < 0.0001) the study groups through Function 1 [Eigen value (EV) = 2.591; cumulative variance (CV) = 78, 7% and Canonical correlation (CC) = 0.849], Function 2 (EV = 0.619; CV = 97.5%; CC = 0.618), and Function 3 (EV = 0.081; CV = 100%; CC = 0.274). The highest Mahalanobis distance (Min D Squared = 0.162) was observed between CML and MDS. For early diagnosis, precise medicine, and good practice in hematologic oncology, DA separated CML, MDS, MM, AML, CLL, and ALL from normal myelogram in Congolese patients.
Keywords
Hematologic Malignancy Types, Classification, Statistics, Congolese Patients
To cite this article
Mireille Solange Nkanga Nganga, Benjamin Longo-Mbenza, Fons Verdonck, Branly Kilola Mbunga, Aimé Tshiyamu Mbaya, Christian Lueme Lokatola, Teke Apalata, Jean-Marie Ntumba Kayembe, Georges Lelo Mvumbi, Blaise Matondo Ma Nzambi Sumbu, Alain Nzonzila Nganga, David Muballe, Cecile Roth Laure Miakassissa Mapapa, Paul Roger Kazadi Beia, Aurore Cecilia Orphée Mbombo Beia, Donatien Nzongola Nkasu Kayembe, Classification of Incident Types of Hematologic Malignancy Using Discriminant Analysis at Kinshasa University Clinics, DR Congo, Clinical Medicine Research. Vol. 8, No. 3, 2019, pp. 56-62. doi: 10.11648/j.cmr.20190803.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Satish Gopal, William A. Wood, Stephanie J. Lee, and al. Meeting the challenge of hematologic malignancies in sub-Saharan Africa. BLOOD, 2012; 119 (22): 5078-5087.
[2]
OMS. Cancer. Aide-mémoire n 297. Mars 2017.
[3]
Pierre Aubry, Bernard-Alex Gaüzère. Les cancers dans les pays en développement Actualités 2017. www.medecinetropicale.com. 16/01/2018.
[4]
Facts 2015-2016 The incidence, prevalence and mortality data in Facts 2015-2016 Cancers Facts and Figures 2016 Atlanta, GA.
[5]
Olaleye O., Ekrikpo U. Epidemiology of Cancers in Sub-Saharan Africa. In: Adedeji O. (eds) Cancer in Sub-Saharan Africa. Springer, 2017; 3-19.
[6]
Schonfeld SJ, Erdmann F, Wiggill T, Singh E, Kellett P, and Babb C, Schüz J. Hematologic malignancies in South Africa-2006: Analysis of data reported to the National Cancer Registry. Cancer Med 2016; 5 (4): 728-738.
[7]
Marshall A. Litchman Battling the hematological Malignancies: The 200 years’ War. The oncologist. 2008; 13 (2): 126-138.
[8]
Mohammad Sorowar Hossain, Mohd S Iqbal, Mohiuddin Ahmed Khan and al. Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals BMC Cancer 2014, 14: 438.
[9]
Mounia Elidrissi Errahhali, Manal Elidrissi Errahhali, Redouane Boulouiz, Meryem Ourzame and Mohammed Bellaoui Distribution and features of hematological malignancies in Easten Morroco: a retrospective multicenter study over 5 years BMC Cancer 2016, 159.
[10]
Makani j, Roberts DJ. Hematology in Africa. Hematol Oncol Clin North Am 2016 Apr; 30 (2): 457-75.
[11]
Abel GA, Klepin HD. Frailty and the management of hematologic malignancies. Blood. 2018; 131 (5): 515-524.
[12]
D A Diallo, L. S Sissoko, Y Sissoko et al. Epidémiologie actuelle des hémopathies malignes dans les services d’hématologie oncologie médicale et de médecine interne de l’hôpital du Point G, Bamako, Mali, Mali Médical 2005 T XX N 4.
[13]
Mashinda KD, Kayembe KP, and Mapatano MA. Prévalence du cancer en République Démocratique du Congo: données anatomopathologiques recueillies aux Cliniques Universitaires de Kinshasa et à l’Hôpital Général de Référence de Kinshasa Ann. Afr. Med. 2012; 6 (4): 1087-1093.
[14]
Hassan M, Abedi-Valugerdi M. Hematologic malignancies in elderly patients. Haematologica. 2014; 99 (7): 1124-7.
[15]
Mufuta N JP, Mbayo K, Kayembe NZ, Gini EK, and Mbuyi M. Cytologie des hémopathies malignes dans deux formations médicales de Kinshasa /DRCongo Ann. Afr. Med, 2013; 6 (4): 1499-1505.
[16]
David P. Steensma. New challenges in evaluating anemia in older persons in the era of molecular testing. ASH Education Book, 2016; 2016 (1): 67-73.
[17]
Dominique Bron, Lionel Ades, Tamas Fulop Valentin Goede, and Reinhar Stauder. Aging and Blood Disorders: New Perspectives, New Challenges. Haematologica April 2015 100: 415-417.
[18]
Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13: 757-772.
[19]
Angelica de Souza Batista Maia Alves, Fernanda Barbi Bataglia, Luciene de Oliveira Conterno, Rosimeire Segato, and Spencer Luiz Marques Payão. Epidemiological and cytogenetic profiles of patients with hematological malignancies and their relationship with aging. Hematol Transfus Cell Ther. 2018 Jul-Sep; 40 (3): 200–206.
[20]
Ouédraogo SM, Hien F, Bazié W, Millogo A, Drabo YJ Place des Hémopathies Malignes en Service de Médecine Interne du CHU de Souro Sanou (Burkina Faso) Mali Médical 2011 Tome XXVI (3): 17-21.
[21]
Elazar J. Pedhazur. Multiple regression in behavioral research: explanation and prediction. Fort Worth: Harcourt Brace College Publishers, c1997.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186