The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation
Clinical Medicine Research
Volume 7, Issue 4, July 2018, Pages: 92-96
Received: Jul. 9, 2018;
Accepted: Aug. 9, 2018;
Published: Oct. 11, 2018
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Zhao Ying, Department of Endocrinology, Jilin Central Hospital, Jilin, China
Liu Xiaoqing, Department of Endocrinology, Jilin Central Hospital, Jilin, China
Su Yang, Department of Endocrinology, Jilin Central Hospital, Jilin, China
Zheng Ying, Department of Endocrinology, Jilin Central Hospital, Jilin, China
Niu Guizhen, Jilin NCMS Management Center, Jilin, China
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Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.
Thyroid Function, Mental Retardation, Intervention Therapy
To cite this article
The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation, Clinical Medicine Research.
Vol. 7, No. 4,
2018, pp. 92-96.
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
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Tiemeier H, Peeters RP. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2016 Jan;4(1):35-43. doi: 10.1016/S2213-8587(15)00327-7.
Levie D, Korevaar TIM, Bath SC, Dalmau-Bueno A, Murcia M, Espada M, Dineva M, Ibarluzea JM, Sunyer J, Tiemeier H, Rebagliato M, Rayman MP, Peeters RP, Guxens M. Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: a Meta-analysis of Individual-participant Data. J Clin Endocrinol Metab. 2018 May 10. doi: 10.1210/jc.2018-00224.
Derakhshan A, Korevaar TIM, Taylor PN, Levie D, Guxens M, Jaddoe VWV, Nelson SM, Tiemeier H, Peeters RP. The Association of Maternal Thyroid Autoimmunity During Pregnancy with Child IQ. J Clin Endocrinol Metab. 2018 Jul 17. doi: 10.1210/jc.2018-00743.
De Leo S, Pearce EN. Autoimmune thyroid disease during pregnancy. Lancet Diabetes Endocrinol. 2018 Jul;6(7):575-586. doi: 10.1016/S2213-8587(17)30402-3.
Korevaar TIM, Tiemeier H, Peeters RP. Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence. Clin Endocrinol (Oxf). 2018 Apr 24. doi: 10.1111/cen.13724.
Mannisto T. Mendola P. Grewal J. et al. Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort [J]. J Clin Endcrinol Metab, 2013, 98(7：2725-2733).
Andersen SL, Olsen J, Wu CS, et al. Spontaneous abortion, stllbirth and hyperthyroidism: a danish population-based study [J]. Eur Thyroid J, 2014, 3(3):164-172.
Millar LK, Wing DA, Leung AS, et al, Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism [J]. Obstet Gynecol, 1994, 84(6):946-949.
Gartner R. Thyroid diseases in pregnancy. Lurr Opin Obstet Gynecol, 2009, 67:178-182.
Debieve F, Duliere S, Bemard P, et, al. To treat or not to treat euthyroid autoimmmmune disorder during pregnancy? Gynecol Obestet Invest, 2009, 67:178-182.
Oken E, BRAVERMAN lE, Plate D, et al. Neonatal Thyroxine, maternal thyroid function, and chijd cognition. J Clin Endocrinol Metab, 2009, 94:497-503.
Rovelli R, Vigone MC, Giovanettoni C, et al. Newborn of mothers affected autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life. Ital J Pediatr, 2010, 36: 24.
Du Peiyi, kitta Zhong Lili, etc. Thyroid autoantibody positive women intervention effect on infants thyroid function during pregnancy. The endocrine metabolism, 2010, 26:931-935.