Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2

Liu-qiang Lv; Yang-zhang Tang; Shi-qiang Wang; Gui Ren; Yu-Chen Lo; Hiroshi Honda; Edward J. Parish

doi:doi:10.11648/j.cmr.20170604.13

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Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2

Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, Hiroshi Honda, Edward J. Parish

Published in Clinical Medicine Research (Volume 6, Issue 4)

Received: 2 May 2017 Accepted: 18 May 2017 Published: 29 June 2017

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Abstract

To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.

Published in	Clinical Medicine Research (Volume 6, Issue 4)
DOI	10.11648/j.cmr.20170604.13
Page(s)	131-134
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Retinol Binding Protein 4, Lipoprotein Associated Phospholipase A2, Coronary Heart Disease, Coronary Artery Lesion Degree

References

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[2]	Maiolino G, Pedon L, Cesari M, et al. Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high rick coronary artery disease patients. PLOS One, 2012, 7(10): e48171.
[3]	Han Yaling. Chang'an International Cardiovascular Forum. Chinese percutaneous coronary intervention guidelines. Chinese Journal of Cardiology, 2012, 40 (4): 252-254.
[4]	Li F, Xia K, Sheikh MS, et al. Retinol binding protein 4 promotes hyperinsulinism-induced proliferation of rat aortic smooth muscle cells, Mol Med Rep, 2014, 9 (5): 1634-1640.
[5]	Ge Ling, Cheng Xunmin, YANG Song, et al. Retinol binding protein 4 and lipoprotein-associated phospholipase A2 levels and coronary heart disease and coronary artery disease characteristics of the correlation analysis. Bengbu Medical College, 40 (8): 1102-1104.
[6]	Fortunato J, Bláha V, Bis J, et al. Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus. J Diabetes Res, 2014, 2014: 278063.
[7]	Caslake M J, Packard C J. Lipoprotein –associated phospholipase A2 (platelet-activating factoracetylhydrolase) and cardiovascular disease. Curr Opin Lipidol, 2003, 14 (4): 347-352.
[8]	Zhao Yong, Guo Zhibin. The value of lipoprotein-associated phospholipase A2 in predicting the risk of coronary heart disease. Journal of Applied Clinical Medicine, 2014, 15 (12): 1-3.
[9]	Ferguson J F, Hinkle CC, Mehta NN, et al. Translational studies of lipoprotein-associated phospholipase A2 in inflammation and atherosclerosis. J AM Coll Cardiol, 2012, 59 (8): 764-772.
[10]	Liu Hai-liang, Li Guo-qing. Relationship between serum retinol-binding protein-4 and high-sensitivity C-reactive protein in patients with coronary heart disease. Journal of Clinical Internal Medicine, 2011, 28 (2): 92-94.
[11]	Liu Xingjia, Zheng Xing, Qin Yongwen, et al. Lipoprotein-related phospholipase A2 activity in response to coronary angiography sclerosis degree, Journal of the Second Military Medical University, 2006, 27: 391-395.
[12]	Cai A, Li G, Chen J, et al. Increased serum level of LP-PLA2 is independentiy associatated with the severity of coronary artery diseases: a cross-sectional study of Chinese population. BMC Cardiovasc Disord, 2015, 15 (1): 14.
[13]	Wang Lili, Lei Changcheng. Lipoprotein-related phospholipase A2 and coronary heart disease related research progress. Modern Medicine and Health, 2015, 31 (1): 57-60.
[14]	Pan Chen-liang, Peng Yu, Hu Xue-ting, et al. Correlation between lipoprotein-associated phospholipase A2 and acute syndromes. Clinical Cardiovascular Diseases, 2014, 30 (11): 962-965.
[15]	Kolodgie F D, Burke A P, Skorija K S, et al. Lipoprotein –associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis. Arterioscler Thromb Vasc Biol, 2006, 26: 2523-2529.

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APA Style

Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. (2017). Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clinical Medicine Research, 6(4), 131-134. https://doi.org/10.11648/j.cmr.20170604.13

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ACS Style

Liu-qiang Lv; Yang-zhang Tang; Shi-qiang Wang; Gui Ren; Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin. Med. Res. 2017, 6(4), 131-134. doi: 10.11648/j.cmr.20170604.13

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AMA Style

Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin Med Res. 2017;6(4):131-134. doi: 10.11648/j.cmr.20170604.13

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@article{10.11648/j.cmr.20170604.13,
  author = {Liu-qiang Lv and Yang-zhang Tang and Shi-qiang Wang and Gui Ren and Yu-Chen Lo and Hiroshi Honda and Edward J. Parish},
  title = {Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {4},
  pages = {131-134},
  doi = {10.11648/j.cmr.20170604.13},
  url = {https://doi.org/10.11648/j.cmr.20170604.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.13},
  abstract = {To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.},
 year = {2017}
}

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TY  - JOUR
T1  - Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2
AU  - Liu-qiang Lv
AU  - Yang-zhang Tang
AU  - Shi-qiang Wang
AU  - Gui Ren
AU  - Yu-Chen Lo
AU  - Hiroshi Honda
AU  - Edward J. Parish
Y1  - 2017/06/29
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UR  - https://doi.org/10.11648/j.cmr.20170604.13
AB  - To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.
VL  - 6
IS  - 4
ER  -

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Author Information

Liu-qiang Lv

Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China
Yang-zhang Tang

Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China
Shi-qiang Wang

Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China
Gui Ren

Department of Bioengineering, Northwestern Polytechnic University, Fremont, USA
Yu-Chen Lo

Department of Bioengineering, Stanford University, Palo Alto, USA
Hiroshi Honda

Department of Bioengineering, Northwestern Polytechnic University, Fremont, USA
Edward J. Parish

Department of Chemistry, Auburn University, Auburn, USA

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Plain Text BibTeX RIS

APA Style

Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. (2017). Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clinical Medicine Research, 6(4), 131-134. https://doi.org/10.11648/j.cmr.20170604.13

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ACS Style

Liu-qiang Lv; Yang-zhang Tang; Shi-qiang Wang; Gui Ren; Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin. Med. Res. 2017, 6(4), 131-134. doi: 10.11648/j.cmr.20170604.13

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AMA Style

Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin Med Res. 2017;6(4):131-134. doi: 10.11648/j.cmr.20170604.13

Copy | Download

@article{10.11648/j.cmr.20170604.13,
  author = {Liu-qiang Lv and Yang-zhang Tang and Shi-qiang Wang and Gui Ren and Yu-Chen Lo and Hiroshi Honda and Edward J. Parish},
  title = {Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {4},
  pages = {131-134},
  doi = {10.11648/j.cmr.20170604.13},
  url = {https://doi.org/10.11648/j.cmr.20170604.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.13},
  abstract = {To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2
AU  - Liu-qiang Lv
AU  - Yang-zhang Tang
AU  - Shi-qiang Wang
AU  - Gui Ren
AU  - Yu-Chen Lo
AU  - Hiroshi Honda
AU  - Edward J. Parish
Y1  - 2017/06/29
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170604.13
DO  - 10.11648/j.cmr.20170604.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 131
EP  - 134
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170604.13
AB  - To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.
VL  - 6
IS  - 4
ER  -

Copy | Download