Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study
Clinical Medicine Research
Volume 6, Issue 4, July 2017, Pages: 121-126
Received: Apr. 11, 2017; Accepted: Apr. 20, 2017; Published: Jun. 1, 2017
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Authors
Ebenezer Adekunle Ajayi, Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria
Patrick Temi Adegun, Department of Surgery, Ekiti State University, Ado Ekiti, Nigeria
Ganiyu Olusola Akanbi, Department of Radiology, Ekiti State University, Ado Ekiti, Nigeria
Akande Oladimeji Ajayi, Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria
Peter Olufemi Areo, Department of Surgery, Ekiti State University, Ado Ekiti, Nigeria
Felix Olukayode Aina, Department of Family Medicine, Ekiti State University Teaching Hospital, Ado Ekiti, Nigeria
Samuel Ayokunle Dada, Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria
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Abstract
Ageing in men is associated with increased prevalence of cardiovascular risk factors and benign prostatic hyperplasia (BPH) with both entities possibly representing downstream manifestations of a common pathogenesis. There is paucity of data on the association of BPH and left ventricular hypertrophy (LVH). This study evaluated relationship between prostate volume, common cardiovascular risk factors and LVH. It was a cross sectional, prospective, hospital-based study. Thirty patients with benign prostatic enlargement (BPE) and 30 age- matched male controls without BPE were studied. All the subjects had clinical, biochemical, prostate ultrasound and echocardiographic evaluation done. SPSS IBM 20 was used to analyze data. Mean age was 65.60 ± 8.11 years (range: 54-82years). Subjects with BPE compared to those without did not significantly differ in age (66.50± 7.75 vs. 64.70±8.49; p=0.39). Significantly higher percentage of subjects with BPE had abnormally low HDL-cholesterol and high blood pressure compared with subjects without BPE. Eight (26.7%) of subjects with BPE in contrast to none of the subjects without BPE had metabolic syndrome (Chi2 = 9.231; p=0.002). Left ventricular mass index were significantly higher in subjects with BPE than in those without. None of the subjects without BPE as compared with 7 (23.3%) of subjects with BPE had echocardiographic determined LVH. Echocardiographic indices that significantly correlated with prostatic volume were: LVPWd (r=0.326, p= 0.011), IVSTd (r= 0.267, p=0.039), LVMI(r=0.308, p= 0.017), LAD (r= 0.494, p <0.0001) and AOD (r= 0.352, p= 0.006). The conclusion was that BPE is associated with increased left ventricular mass index and metabolic syndrome, mostly driven by elevated blood pressure and low serum HDL-cholesterol.
Keywords
Benign Prostatic Hypertrophy, Prostatic Volume, Left Ventricular Hypertrophy, Metabolic Syndrome, Left Ventricular Mass Index
To cite this article
Ebenezer Adekunle Ajayi, Patrick Temi Adegun, Ganiyu Olusola Akanbi, Akande Oladimeji Ajayi, Peter Olufemi Areo, Felix Olukayode Aina, Samuel Ayokunle Dada, Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study, Clinical Medicine Research. Vol. 6, No. 4, 2017, pp. 121-126. doi: 10.11648/j.cmr.20170604.11
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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