A Novel Streptomycin and Spectinomycin Resistance Gene Cassette Occurence in E. cloacae isolated from Zhenjiang
Clinical Medicine Research
Volume 3, Issue 5, September 2014, Pages: 142-144
Received: Aug. 11, 2014;
Accepted: Sep. 5, 2014;
Published: Sep. 20, 2014
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Hongxia Wu, Department of Microbiology, Jiangyin people’s hospital, Jiangyin, China, 214400
The aadA genes, encoding resistance to streptomycin and spectinomycin, have been found as gene cassettes in different gram-negative and gram-positive bacterial species. The present report has revealed that the sequence of a new gene, aadA5, combining with the trimethoprim resistance gene dfr17 occured in a class 1integron. The integron was identified in a nosocomial pathogen Enterobacter cloacae isolates, which indicated that integrons are specialized genetic elements that were capable of capturing, integrating and mobilizing gene-cassette by site-specific recombination and integron was a dangerous factor to lead to bacterial resistance.
A Novel Streptomycin and Spectinomycin Resistance Gene Cassette Occurence in E. cloacae isolated from Zhenjiang, Clinical Medicine Research.
Vol. 3, No. 5,
2014, pp. 142-144.
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