Clinical Medicine Research
Volume 3, Issue 2, March 2014, Pages: 40-43
Received: Mar. 2, 2014;
Published: Mar. 30, 2014
Views 3665 Downloads 251
Arzu Ataseven, Department of Dermatology, Konya Training and Research Hospital, Konya, Turkey
Aynur Ugur Bilgin, Department of Hematology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
Gulcan Saylam Kurtipek, Department of Dermatology, Konya Training and Research Hospital, Konya, Turkey
Perihan Ozturk, Department of Dermatology, Faculty of Medicine, Sutcu Imam University, Kahramanmaraş, Turkey
Nursel Dilek, Department of Dermatology, Faculty of Medicine, Rize University, Rize, Turkey
Huseyin Ataseven, Department of Gastroenterology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
Objective: The aim of this study is to assess the neutrophil lymphocyte ratio (NLR) as an inflammatory marker in patients with psoriasis and to compare it with healthy subjects and to evaluate the correlation with the severity of the disease. Methods: 104 psoriasis patients and 70 healthy persons were included as the control group. The laboratory results were recorded retrospectively from the patients’ files and controls. NLR was calculated by the division of the neutrophil count to the lymphocyte count in the hemogram test. The dermatologic examinations and psoriatic area severity index (PASI) scoring were performed by the same dermatologist. Results: Leukocyte, neutrophil, NLR levels of the psoriasis patients were significantly elevated compared to those of the control group (p<0.05, p<0.01 and p<0.01 respectively). There were no correlation between NLR and PASI score (p>0.05) in the patient group. Conclusions: NLR, an emerging marker of inflammation, is higher in patients with psoriasis.
Aynur Ugur Bilgin,
Gulcan Saylam Kurtipek,
The Importance of Neutrophil Lymphocyte Ratio in Patients with Psoriasis, Clinical Medicine Research.
Vol. 3, No. 2,
2014, pp. 40-43.
Ozden MG, Denizli H, Caycı YT et al. Correlation between serum galectin-3 levels and disease severity in psoriasis vulgaris. Turkderm 2011;45:152-54.
Imtiaz F, Shafique K, Mirza SS et al. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;26;5:2.
Torun S, Tunc BD, Suvak B, Yildiz H, Tas A, Sayilir A, Ozderin YO, Beyazit Y, Kayacetin E. Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity. Clin Res Hepatol Gastroenterol 2012; 36:491-7.
Biyik M, Ucar R, Solak Y, Gungor G, Polat I, Gaipov A, Cakir OO, Ataseven H, Demir A, Turk S, Polat H. Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis. Eur J Gastroenterol Hepatol2013; 25:435-41.
Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, Sancakdar E, Sencan M. Is neutrophil/lymphocyte ratio associated with subclinical inflammation and amyloidosis in patients with familial mediterranean fever? Biomed Res Int 2013; 2013:185317.
Sonmez O, Ertas G, Bacaksız A, Tasal A, Erdogan E, Asoglu E, Uyarel H, Goktekin O. Relation neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg 2013; 2013.188.
Kao SC, Pavlakis N, Harvie R et al. High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin Cancer Res 2010;16:5805-13.
Gulekon A, Adisen E. Psoriasis and comorbidities. Turkderm 2008; 42:23-5.
Fraga NA, Oliveria Mde F, Follador I, Rocha Bde O, Rego VR. Psoriasis and uveitis: a literature review. An Bras Dermatol 2012; 87:877-83.
Azab B, Daoud J, Naeem FB et al. Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study). Ren Fail 2012;34:571-6.
Ahsen A, Ulu MS, Yuksel S, Demir K, Uysal M, Erdogan M, Acarturk G. As a new inflammatory marker for familial Mediterranean fever: Neutrophil-to-lymphocyte ratio. Inflammation 2013 Jun 21 [Epub ahead of print].
Ma JP, Wang Z, Lin JWet al. Neutrophil-to-lymphocyte ratio as a prognostic factor in gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi 2011;14:944-7.
Wang GY, Yang Y, Li Hetal. A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One 2011;6(9):e25295.
Gondo T, Nakashima J, Ohno Y et al. Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy. Urology 2012;79:1085-91.
Muhmmed Suliman MA, Bahnacy Juma AA, Ali Almadhani AA, Pathare AV, Alkindi SS, Uwe Werner F. Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome. Arch Med Res 2010; 41:618-22.
Celikbilek M, Dogan S, Ozbakir O, Zararsiz G, Kucuk H, Gursoy S, Yurci A, Guven K, Yucesoy M. Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013; 27:72-6.
Fredriksson T, Pettersson U. Severe psoriasis—oral therapy with a new retinoid. Dermatologica 1978; 157:238-44.
Arican O, Aral M, Sasmaz S, Ciragil P. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 2005; 24: 273-9.
Czech W, Schöpf E, Kapp A. Soluble E-selectin in sera of patients with atopic dermatitis and psoriasis-correlation with disease activity. Br J Dermatol 1996; 134:17-21.
Ceyhan AM, Yildirim M, Ceyhan BM, Sutcu R. Serum neopterin and TNF-α levels in psoriasis and their correlation with disease severity. Turkderm 2012; 46:7-10.