Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma
Clinical Medicine Research
Volume 3, Issue 2, March 2014, Pages: 36-39
Received: Mar. 3, 2014; Published: Mar. 30, 2014
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Ibrahim Keles, Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey
Cavit Ceylan, Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
Erdogan Aglamis, Department of urology, Elazig Education and Research Hospital, Elazig, Turkey
Hasan Salih Saglam, Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey
Mustafa Karalar, Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey
Soner Coban, Department of urology, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey
Sait Bicer, Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
Oztug Adsan, Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey
Mehmet Ozgur Yucel, Department of urology, Adiyaman University, Education and Research Hospital, Adiyaman, Turkey
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Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.
Renal Cell Carcinoma, Stage, Grade, Mean Platelet Volume
To cite this article
Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, Soner Coban, Sait Bicer, Oztug Adsan, Mehmet Ozgur Yucel, Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma, Clinical Medicine Research. Vol. 3, No. 2, 2014, pp. 36-39. doi: 10.11648/j.cmr.20140302.16
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