Clinical Medicine Research

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Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma

Received: 03 March 2014    Accepted:     Published: 30 March 2014
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Abstract

Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.

DOI 10.11648/j.cmr.20140302.16
Published in Clinical Medicine Research (Volume 3, Issue 2, March 2014)
Page(s) 36-39
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Renal Cell Carcinoma, Stage, Grade, Mean Platelet Volume

References
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Author Information
  • Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey

  • Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey

  • Department of urology, Elazig Education and Research Hospital, Elazig, Turkey

  • Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey

  • Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey

  • Department of urology, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey

  • Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey

  • Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey

  • Department of urology, Adiyaman University, Education and Research Hospital, Adiyaman, Turkey

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  • APA Style

    Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. (2014). Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clinical Medicine Research, 3(2), 36-39. https://doi.org/10.11648/j.cmr.20140302.16

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    ACS Style

    Ibrahim Keles; Cavit Ceylan; Erdogan Aglamis; Hasan Salih Saglam; Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin. Med. Res. 2014, 3(2), 36-39. doi: 10.11648/j.cmr.20140302.16

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    AMA Style

    Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin Med Res. 2014;3(2):36-39. doi: 10.11648/j.cmr.20140302.16

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  • @article{10.11648/j.cmr.20140302.16,
      author = {Ibrahim Keles and Cavit Ceylan and Erdogan Aglamis and Hasan Salih Saglam and Mustafa Karalar and Soner Coban and Sait Bicer and Oztug Adsan and Mehmet Ozgur Yucel},
      title = {Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma},
      journal = {Clinical Medicine Research},
      volume = {3},
      number = {2},
      pages = {36-39},
      doi = {10.11648/j.cmr.20140302.16},
      url = {https://doi.org/10.11648/j.cmr.20140302.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cmr.20140302.16},
      abstract = {Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma
    AU  - Ibrahim Keles
    AU  - Cavit Ceylan
    AU  - Erdogan Aglamis
    AU  - Hasan Salih Saglam
    AU  - Mustafa Karalar
    AU  - Soner Coban
    AU  - Sait Bicer
    AU  - Oztug Adsan
    AU  - Mehmet Ozgur Yucel
    Y1  - 2014/03/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.cmr.20140302.16
    DO  - 10.11648/j.cmr.20140302.16
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 36
    EP  - 39
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20140302.16
    AB  - Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.
    VL  - 3
    IS  - 2
    ER  - 

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