Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone
Clinical Medicine Research
Volume 2, Issue 6, November 2013, Pages: 162-166
Received: Dec. 1, 2013;
Published: Dec. 20, 2013
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Mahmoud Hassan El-Bidawy, Department of Biomedical Sciences, Division of Physiology, College of Medicine, Salman bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Medical Physiology, Faculty of Medicine, Cairo University, Egypt
Nabil Mohamed Elbahey, Department of Biomedical Sciences, Division of Pharmacology, College of Medicine, Salman bin Abdulaziz University, Al Kharj, Saudi Arabia
Mohamed Mahmoud Shaaban, Department of Biomedical Sciences, Division of Histology, College of Medicine, Salman bin Abdulaziz University, Al Kharj ,Saudi Arabia
Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance . Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance . Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol  and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of . Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro  and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity . Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism  Furthermore, adiponectin levels are inversely associated with visceral adiposity . Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].
Mahmoud Hassan El-Bidawy,
Nabil Mohamed Elbahey,
Mohamed Mahmoud Shaaban,
Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone, Clinical Medicine Research.
Vol. 2, No. 6,
2013, pp. 162-166.
Khan, M. Safdar, M.M. Ali Khan, K.N. Khattak and R.A. Anderson. Diabetes Care, 26 , pp. 3215–3218. | View Record in Scopus | | Full Text via CrossRef | Cited By in Scopus .
A.M. Roussel, I. Hininger, R. Benaraba, T.N. Ziegenfuss and R.A. Anderson. J. Am. Coll. Nutr., 28 , pp. 16–21. | View Record in Scopus | | Cited By in Scopus .
Qin, M. Nagasaki, M. Ren, G. Bajotto, Y. Oshida and Y. Sato. Horm. Metab. Res., 36 , pp. 119–125. | View Record in Scopus | | Cited By in Scopus .
Besse C, Nicod N, Tappy L: Changes in insulin secretion and glucose metabolism induced by dexamethasone in lean and obese females.Obes Res 2005, 13:306-311.
Bullen JW Jr, Bluher S, Kelesidis T, Mantzoros CS: Regulation of adiponectin and its receptors in response to development of diet-induced obesity inmice. Am J Physiol Endocrinol Metab 2007, 292:1079-1086.
Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L: Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001, 108:1875-1881.
Cristiane de Oliveira, Ana BM de Mattos, Carolina Biz, Lila M Oyama, Eliane B Ribeiro, and Cláudia Maria Oller do Nascimento,High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations;Lipids in Health and Disease 2011, Volume10,pp 10:11.
Davis GF: Adverse effects of corticosteroids: II. Systemic. Clin Dermatol 1986, 4:161-169.
Degawa-Yamauchi M, Moss KA, Bovenkerk JE, Shankar SE, Morrison CL, Lelliott CJ, Vidal-Puig A, Jones R, Considine RV: Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and TNF-α. Obes Res 2005, 13:662-669.
Díez JJ, Iglesias P [March 2003]. "The role of the novel adipocyte-derived hormone adiponectin in human disease". Eur. J. Endocrinol. 148 : 293–300.
Diez JJ, Iglesias P: The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003, 148:293-300.
J.G. Wang, R.A. Anderson, G.M. Graham, M.C. Chu, M.V. Sauer, M.M. Guarnaccia and R.A. Lobo. Fertil. Steril., 88 , pp. 240–243.
Jang C, Inder WJ, Obeyesekere VR, Alford FP: Adiponectin, skeletal muscleadiponectin receptor expression and insulin resistance following dexamethasone. Clin Endocrinol [Oxf] 2008, 69:745-750.
Klöting N, Fasshauer M, Dietrich A, Kovacs P, Schön MR, Kern M, Stumvoll M, Blüher M: Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010, 299:506-515.
Matsuzawa Y: Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci 2010, 86:131-141.
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S: Lack of increase of serum adiponectin concentrations with a moderate weight loss during six months on a high-caloric diet in military service among a young male Finnish population. Endocrine 2005, 26:65-69.
Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y,Yamashita S, Funahashi T, Matsuzawa Y: Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and classAscavenger receptor expression inhuman monocyte-derived macrophages. Circulation 2001, 103:1057-1063
Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2001, 87:4652-4656.
Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA: Sung Hee Kim, Se Young Choung Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae [Cinnamon bark] extract in C57BL/Ks db/db mice Archives of Pharmacal Research February 2010, Volume 33, Issue 2, pp 325-333.
T.N. Ziegenfuss, J.E. Hofheins, R.W. Mendel, J. Landis and R.A. Anderson. J. Int. Soc. Sports Nutr., 3 , pp. 45–53. | View Record in Scopus | | Full Text via CrossRef | Cited By in Scopus .
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S,Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P,Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002, 8:1288-1295.