Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study
American Journal of Physical Chemistry
Volume 2, Issue 2, April 2013, Pages: 44-51
Received: Apr. 15, 2013; Published: Apr. 2, 2013
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Authors
I. P. Ivanova, Fundamental Research Laboratory of Physicochemical Studies, Scientific Research Institute of Applied Fundamental Medicine, Nizhny Novgorod State Medical Academy. (NNSMA), Minin and Pojarsky square, 10/1, 603005, Nizhny Novgorod, Russian Federation
I. M. Piskarev, D.V. Skobeltsin Institute of Nuclear Physics M.V. Lomonosov Moscow State University (NPI MSU), 1(2), Leninskie gory, Moscow, 119234, Russian Federation
S. V. Trofimova, Fundamental Research Laboratory of Physicochemical Studies, Scientific Research Institute of Applied Fundamental Medicine, Nizhny Novgorod State Medical Academy. (NNSMA), Minin and Pojarsky square, 10/1, 603005, Nizhny Novgorod, Russian Federation
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Abstract
Mechanism of initial stage lipid peroxidation with HO2• radicals was investigated. The source of radicals was electric spark discharge radiation on air, rate of radicals generation in sample was 1.2 106 M (l s)1. The kinetic model of process was developed, based on the classical chain oxidation theory. Some process characteristics was calculated by means of numerical solution the system 24 differential equations of chemical kinetics. Initial lipid concentration was taken equals 2 103 M/l. It was shown the unsaturated lipids concentration after 2 hours treatment to spark discharge decrease in ~ 2 times, whereas for saturated lipids decreasing is only 7%. The hydroperoxides production was calculated. The new diene conjugate appearance in treated to spark discharge sample at lipids concentration 2 103 M l1 and treatment time about 10 minutes can't be detected, and just having in sample diens are destroyed. According simulation results, diene conjugates content is increased during treatment to spark discharge radiation at large lipids concentration, having 2 double bonds, (~0.5 M l1). This result is confirmed in experiment with sunflower oil (69% linoleic acid). The dependence of dienes concentration in sample from properties (intensities) external irradiation is ambiguous.
Keywords
Saturated And Unsaturated Fatty Acids, Diene Conjugates, Radicals Ho2•, Simulation
To cite this article
I. P. Ivanova, I. M. Piskarev, S. V. Trofimova, Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study, American Journal of Physical Chemistry. Vol. 2, No. 2, 2013, pp. 44-51. doi: 10.11648/j.ajpc.20130202.13
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