Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Ayman M. F. Elgohary; E. M. Ezz El-Arab

doi:doi:10.11648/j.sjc.20130101.11

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Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Ayman M. F. Elgohary, E. M. Ezz El-Arab

Received: 16 March 2013 Accepted: Published: 2 April 2013

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Abstract

A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL

DOI	10.11648/j.sjc.20130101.11
Published in	Science Journal of Chemistry (Volume 1, Issue 1, April 2013)
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pyrido[2,3-D][1,3]Oxazin-4-One, 2-Propylpyrido[2,3-D]Pyrimidin-4(3h)-One, Antitumor

References

[1]	S.N. VanderWel, P.J. Harvey, D.J. McNamara, J.T. Repine, P.R. Keller, J. Quin III, R.J. Booth, W.L. Elliott, E.M. Dobrusin, D.W. Fry, P.L. Toogood, J. Med. Chem 48 (2005) 2371e2378.
[2]	P.L. Toogood, P.J. Harvey, J.T. Repine, D.J. Sheehan, S.N. VanderWel, H. Zhou, P.R. Keller, D.J. McNamara, D. Sherry, T. Zhu, J. Brodfuehrer, C. Choi, M.R. Barvian, D.W. Fry, J. Med. Chem 48 (2005) 2388e2406.
[3]	B.D. Palmer, J.B. Smaill, G.W. Rewcastle, E.M. Dobrusin, A. Kraker, C.W. Moore, R.W. Steinkampf, W.A. Denny, Bioorg. Med.
[4]	K. Malagu, H. Duggan, K. Menear, M. Hummersone, S. Gomez, C. Bailey, P. Edwards, J. Drzewiecki, F. Leroux, M.J. Quesada, G. Hermann, S. Maine, C. Molyneaux, A. Le Gall, J. Pullen, I. Hickson, L. Smith, S. Maguire, N. Martin, G. Smith, M. Pass, Bioorg. Med. Chem. Lett. 19 (2009) 5950e5953.
[5]	X.L. Zhao, Y.F. Zhao, S.C. Guo, H.S. Song, D. Wang, P. Gong, Molecules 12 (2007) 1136e1146.
[6]	H.N. Hafez, A.B.A. El-Gazzar, Bioorg. Med. Chem. Lett. 19 (2009) 4143e4147.
[7]	A.S. Shawali, S.M. Sherif, M.A.A. Darwish, M.M. El-merzabani, Arch. Pharm. Res. 33 (2010) 55e60.
[8]	(a) Masuda, Satoru et al. Jpn.Kokai. Tokkyo Koho Jp 03, 106, 880. C.A.15: 183361d. (b) Tamura et al. Jpn. Kokai. Tokkyo Koho Jp 61, 249, 983, C.A. 106: 213979.
[9]	J. Ram, D.A. Vanden Berghe, A.J.J. Vlietinck, Heterocycl. Chem. 28 (1988) 217.
[10]	J.R. Piper, G.S. Mc Calab, J.A. Montgomery, R.L. Kishiuk, Y. Gamount, F.M. Sirotnak, J. Med. Chem. 29 (1986) 1080e1087.
[11]	R.K. Robins, G.H.J. Hitchings, Am. Chem. Soc. 80 (1958) 3449.
[12]	M.F. Hasan, A.M. Madkour, I. Saleem, J.M.A. Rahman, E.A.Z. Mohammed, Heterocycles 38 (1994) 57.
[13]	John Adams Lowe,Chem. Abstr. 112 (1990) 21008 Austrian At. 388378 (1989) 378.
[14]	A. Gangjee, O.O. Adair, S.F. Queener, J. Med. Chem. 46 (2003) 5074e5082. H. Iwamura, S. Murakami, K. Koshimizu, S. Matsabura, J. Med. Chem. 28 (1985)577e583.

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Ayman M. F. Elgohary, E. M. Ezz El-Arab. (2013). Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Science Journal of Chemistry, 1(1), 1-6. https://doi.org/10.11648/j.sjc.20130101.11

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ACS Style

Ayman M. F. Elgohary; E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci. J. Chem. 2013, 1(1), 1-6. doi: 10.11648/j.sjc.20130101.11

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AMA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci J Chem. 2013;1(1):1-6. doi: 10.11648/j.sjc.20130101.11

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@article{10.11648/j.sjc.20130101.11,
  author = {Ayman M. F. Elgohary and E. M. Ezz El-Arab},
  title = {Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20130101.11},
  url = {https://doi.org/10.11648/j.sjc.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130101.11},
  abstract = {A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL},
 year = {2013}
}

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TY  - JOUR
T1  - Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
AU  - Ayman M. F. Elgohary
AU  - E. M. Ezz El-Arab
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130101.11
DO  - 10.11648/j.sjc.20130101.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
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PB  - Science Publishing Group
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AB  - A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
VL  - 1
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Author Information

Ayman M. F. Elgohary

Department of medical laboratories College of Applied Medical Science, Majmaah University, Almajma’ah 11952, KSA
E. M. Ezz El-Arab

National Organization For Drug Control & Research, Pharmaceutical Chemistry Division, Giza, Egypt

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APA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. (2013). Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Science Journal of Chemistry, 1(1), 1-6. https://doi.org/10.11648/j.sjc.20130101.11

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ACS Style

Ayman M. F. Elgohary; E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci. J. Chem. 2013, 1(1), 1-6. doi: 10.11648/j.sjc.20130101.11

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AMA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci J Chem. 2013;1(1):1-6. doi: 10.11648/j.sjc.20130101.11

Copy | Download

@article{10.11648/j.sjc.20130101.11,
  author = {Ayman M. F. Elgohary and E. M. Ezz El-Arab},
  title = {Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20130101.11},
  url = {https://doi.org/10.11648/j.sjc.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130101.11},
  abstract = {A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
AU  - Ayman M. F. Elgohary
AU  - E. M. Ezz El-Arab
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130101.11
DO  - 10.11648/j.sjc.20130101.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20130101.11
AB  - A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
VL  - 1
IS  - 1
ER  -

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