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Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands

Received: 15 May 2019    Accepted: 17 June 2019    Published: 01 July 2019
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Abstract

A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.

DOI 10.11648/j.sjc.20190702.13
Published in Science Journal of Chemistry (Volume 7, Issue 2, April 2019)
Page(s) 49-55
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Salicylaldiminato Pt (II) Complexes, Synthesis, Photophysical Properties, Cytotoxicity

References
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Author Information
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

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    Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. (2019). Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Science Journal of Chemistry, 7(2), 49-55. https://doi.org/10.11648/j.sjc.20190702.13

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    ACS Style

    Quang Trung Nguyen; Quang Hai Lam; Phuong Nam Pham Thi; Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci. J. Chem. 2019, 7(2), 49-55. doi: 10.11648/j.sjc.20190702.13

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    AMA Style

    Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci J Chem. 2019;7(2):49-55. doi: 10.11648/j.sjc.20190702.13

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  • @article{10.11648/j.sjc.20190702.13,
      author = {Quang Trung Nguyen and Quang Hai Lam and Phuong Nam Pham Thi and Van Tuyen Nguyen},
      title = {Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands},
      journal = {Science Journal of Chemistry},
      volume = {7},
      number = {2},
      pages = {49-55},
      doi = {10.11648/j.sjc.20190702.13},
      url = {https://doi.org/10.11648/j.sjc.20190702.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjc.20190702.13},
      abstract = {A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands
    AU  - Quang Trung Nguyen
    AU  - Quang Hai Lam
    AU  - Phuong Nam Pham Thi
    AU  - Van Tuyen Nguyen
    Y1  - 2019/07/01
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjc.20190702.13
    DO  - 10.11648/j.sjc.20190702.13
    T2  - Science Journal of Chemistry
    JF  - Science Journal of Chemistry
    JO  - Science Journal of Chemistry
    SP  - 49
    EP  - 55
    PB  - Science Publishing Group
    SN  - 2330-099X
    UR  - https://doi.org/10.11648/j.sjc.20190702.13
    AB  - A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.
    VL  - 7
    IS  - 2
    ER  - 

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