Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering
International Journal of Materials Science and Applications
Volume 7, Issue 2, March 2018, Pages: 62-68
Received: Feb. 23, 2018;
Accepted: Mar. 9, 2018;
Published: Apr. 2, 2018
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Nisat Tamanna Nipu, Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Bangladesh
Farzana Khan Rony, Institute of Glass and Ceramic Research and Testing, Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh
Asaduz Zaman, Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Bangladesh
In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.
Nisat Tamanna Nipu,
Farzana Khan Rony,
Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering, International Journal of Materials Science and Applications.
Vol. 7, No. 2,
2018, pp. 62-68.
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