Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Safwan Ashour; Roula Bayram

doi:doi:10.11648/j.mc.20170506.12

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Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Safwan Ashour, Roula Bayram

Published in Modern Chemistry (Volume 5, Issue 6)

Received: 25 January 2017 Accepted: 10 February 2017 Published: 28 November 2017

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Abstract

A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL^-1 with detection limit of 0.013 and 0.75 μg mL^-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.

Published in	Modern Chemistry (Volume 5, Issue 6)
DOI	10.11648/j.mc.20170506.12
Page(s)	93-100
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Extractive Colorimetry, Fexofenadine Hydrochloride, Irbesartan, Naphthol Blue Black, Pharmaceuticals

References

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Safwan Ashour, Roula Bayram. (2017). Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Modern Chemistry, 5(6), 93-100. https://doi.org/10.11648/j.mc.20170506.12

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ACS Style

Safwan Ashour; Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod. Chem. 2017, 5(6), 93-100. doi: 10.11648/j.mc.20170506.12

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AMA Style

Safwan Ashour, Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod Chem. 2017;5(6):93-100. doi: 10.11648/j.mc.20170506.12

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@article{10.11648/j.mc.20170506.12,
  author = {Safwan Ashour and Roula Bayram},
  title = {Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals},
  journal = {Modern Chemistry},
  volume = {5},
  number = {6},
  pages = {93-100},
  doi = {10.11648/j.mc.20170506.12},
  url = {https://doi.org/10.11648/j.mc.20170506.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20170506.12},
  abstract = {A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.},
 year = {2017}
}

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TY  - JOUR
T1  - Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals
AU  - Safwan Ashour
AU  - Roula Bayram
Y1  - 2017/11/28
PY  - 2017
N1  - https://doi.org/10.11648/j.mc.20170506.12
DO  - 10.11648/j.mc.20170506.12
T2  - Modern Chemistry
JF  - Modern Chemistry
JO  - Modern Chemistry
SP  - 93
EP  - 100
PB  - Science Publishing Group
SN  - 2329-180X
UR  - https://doi.org/10.11648/j.mc.20170506.12
AB  - A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.
VL  - 5
IS  - 6
ER  -

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Author Information

Safwan Ashour

Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria
Roula Bayram

Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria

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Safwan Ashour, Roula Bayram. (2017). Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Modern Chemistry, 5(6), 93-100. https://doi.org/10.11648/j.mc.20170506.12

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ACS Style

Safwan Ashour; Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod. Chem. 2017, 5(6), 93-100. doi: 10.11648/j.mc.20170506.12

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AMA Style

Safwan Ashour, Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod Chem. 2017;5(6):93-100. doi: 10.11648/j.mc.20170506.12

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@article{10.11648/j.mc.20170506.12,
  author = {Safwan Ashour and Roula Bayram},
  title = {Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals},
  journal = {Modern Chemistry},
  volume = {5},
  number = {6},
  pages = {93-100},
  doi = {10.11648/j.mc.20170506.12},
  url = {https://doi.org/10.11648/j.mc.20170506.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20170506.12},
  abstract = {A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals
AU  - Safwan Ashour
AU  - Roula Bayram
Y1  - 2017/11/28
PY  - 2017
N1  - https://doi.org/10.11648/j.mc.20170506.12
DO  - 10.11648/j.mc.20170506.12
T2  - Modern Chemistry
JF  - Modern Chemistry
JO  - Modern Chemistry
SP  - 93
EP  - 100
PB  - Science Publishing Group
SN  - 2329-180X
UR  - https://doi.org/10.11648/j.mc.20170506.12
AB  - A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.
VL  - 5
IS  - 6
ER  -

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