Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats

Charles Obiora Nwonuma; Emenike Onyebum Irokanulo; Adeyemi Eunice Jolaiya; Ayokanmi Ore

doi:doi:10.11648/j.ajls.20150303.21

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Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats

Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore

Published in American Journal of Life Sciences (Volume 3, Issue 3)

Received: 9 May 2015 Accepted: 15 May 2015 Published: 27 May 2015

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Abstract

This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.

Published in	American Journal of Life Sciences (Volume 3, Issue 3)
DOI	10.11648/j.ajls.20150303.21
Page(s)	203-212
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Annona senegalensis, Testes, Testicular Function, Histopathology, Rat

References

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APA Style

Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. (2015). Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. American Journal of Life Sciences, 3(3), 203-212. https://doi.org/10.11648/j.ajls.20150303.21

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ACS Style

Charles Obiora Nwonuma; Emenike Onyebum Irokanulo; Adeyemi Eunice Jolaiya; Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am. J. Life Sci. 2015, 3(3), 203-212. doi: 10.11648/j.ajls.20150303.21

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AMA Style

Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am J Life Sci. 2015;3(3):203-212. doi: 10.11648/j.ajls.20150303.21

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@article{10.11648/j.ajls.20150303.21,
  author = {Charles Obiora Nwonuma and Emenike Onyebum Irokanulo and Adeyemi Eunice Jolaiya and Ayokanmi Ore},
  title = {Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats},
  journal = {American Journal of Life Sciences},
  volume = {3},
  number = {3},
  pages = {203-212},
  doi = {10.11648/j.ajls.20150303.21},
  url = {https://doi.org/10.11648/j.ajls.20150303.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150303.21},
  abstract = {This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.},
 year = {2015}
}

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TY  - JOUR
T1  - Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats
AU  - Charles Obiora Nwonuma
AU  - Emenike Onyebum Irokanulo
AU  - Adeyemi Eunice Jolaiya
AU  - Ayokanmi Ore
Y1  - 2015/05/27
PY  - 2015
N1  - https://doi.org/10.11648/j.ajls.20150303.21
DO  - 10.11648/j.ajls.20150303.21
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 203
EP  - 212
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20150303.21
AB  - This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.
VL  - 3
IS  - 3
ER  -

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Author Information

Charles Obiora Nwonuma

Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Emenike Onyebum Irokanulo

Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Adeyemi Eunice Jolaiya

Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, Omuaran Kwara State, Nigeria
Ayokanmi Ore

Biochemistry Unit, Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Oyo State, Nigeria

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APA Style

Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. (2015). Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. American Journal of Life Sciences, 3(3), 203-212. https://doi.org/10.11648/j.ajls.20150303.21

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ACS Style

Charles Obiora Nwonuma; Emenike Onyebum Irokanulo; Adeyemi Eunice Jolaiya; Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am. J. Life Sci. 2015, 3(3), 203-212. doi: 10.11648/j.ajls.20150303.21

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AMA Style

Charles Obiora Nwonuma, Emenike Onyebum Irokanulo, Adeyemi Eunice Jolaiya, Ayokanmi Ore. Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats. Am J Life Sci. 2015;3(3):203-212. doi: 10.11648/j.ajls.20150303.21

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@article{10.11648/j.ajls.20150303.21,
  author = {Charles Obiora Nwonuma and Emenike Onyebum Irokanulo and Adeyemi Eunice Jolaiya and Ayokanmi Ore},
  title = {Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats},
  journal = {American Journal of Life Sciences},
  volume = {3},
  number = {3},
  pages = {203-212},
  doi = {10.11648/j.ajls.20150303.21},
  url = {https://doi.org/10.11648/j.ajls.20150303.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150303.21},
  abstract = {This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats
AU  - Charles Obiora Nwonuma
AU  - Emenike Onyebum Irokanulo
AU  - Adeyemi Eunice Jolaiya
AU  - Ayokanmi Ore
Y1  - 2015/05/27
PY  - 2015
N1  - https://doi.org/10.11648/j.ajls.20150303.21
DO  - 10.11648/j.ajls.20150303.21
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 203
EP  - 212
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20150303.21
AB  - This study evaluated the effect of Annona senegalensis on selected biochemical and testicular function indices in rats. Twenty Wistar rats (125 – 127 g) were randomly assigned into four experimental groups: A, B, C and D, (n = 5/ group). Animals in group A served as control and was administered distilled water, while animals in groups B, C, and D were given 100 mg/kg body weight (bw), 200 mg/kg bw and 300 mg/kg bw of aqueous leaf extract of Annona senegalensis (ALEAS) respectively by oral gavage for 21 days. Data revealed a significant decrease (P < 0.05) in the testis-body weight ratio and total protein content in the testes of rats administered ALEAS compared to the control. There was also a significant increase (P < 0.05) in testicular cholesterol, glycogen, malondialdhyde (MDA) and catalase (CAT) activity. Additionally, histopathological studies revealed a marked degeneration of seminiferous tubules. Overall, data from the present study suggest that aqueous leaf extract of Annona senegalensis may possess the potential to adversely affect testicular function in rat.
VL  - 3
IS  - 3
ER  -

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