Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis
American Journal of Life Sciences
Volume 3, Issue 1-4, January 2015, Pages: 7-13
Received: Nov. 19, 2014; Accepted: Nov. 22, 2014; Published: Dec. 27, 2014
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Authors
Zhiying Luo, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Xi Li, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Mouze Liu, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Yan Shu, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Jiye Yin, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Xiaoping Chen, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Jianquan Luo, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
Xiaobing Li, Department of Cardio-Thoracic Surgery, the Second Xiangya Hospital Hospital of Central South University, Middle Ren-Min Road No. 139, Changsha, Hunan 410011, PR China
Wei Zhang, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
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Abstract
Objective: Association studies on the effects of GGCX gene polymorphisms on warfarin stable dose have shown conflicting results. The aim of this study is to quantitatively summarize whether GGCX gene polymorphisms have potential roles in warfarin dose requirement. Methods: Publications were searched in PubMed, Medline and ISI Web of Knowledge and chosen by exact inclusion and exclusion criteria. A meta-analysis was conducted by using Revman 5.0 software to determine the association between common polymorphisms of the three genes and warfarin dose requirement. Results: Data were extracted from 13 publications with 4167 patients enrolled. Two common polymorphisms (rs699664, rs12714145) of GGCX were included for further meta-analyses. Comparing to rs699664AA geontype carriers, rs699664GG genotype carriers requered higer 3% [95% CI: 2% - 4%, P-valus < 0.0001] warfarin dose. The warfarin dosage requirement showed no significant difference between rs699664GG and rs699664GA genotype carriers, P=0.51. Compared to rs12714145AA carriers, the GG and GA genotype carriers needed 5% (95% CI, 1% - 9%; P = 0.01) and 4% (95% CI, 1% - 8%; P = 0.02) lower warfarin dosage, respectively. The warfarin dosage requirement showed no significant difference between GG and GA genotype carriers, P=0.12. Conclusion: Our study showed that GGCX polymorphisms were significantly associated with warfarin dose requirement. These polymorphisms should be considered in future warfarin personalized treatment.
Keywords
GGCX, Warfarin, Polymorphism, Meta-Analysis
To cite this article
Zhiying Luo, Xi Li, Mouze Liu, Yan Shu, Jiye Yin, Xiaoping Chen, Jianquan Luo, Xiaobing Li, Wei Zhang, Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis, American Journal of Life Sciences. Special Issue: Pharmacogenomics & Personalized Medicine. Vol. 3, No. 1-4, 2015, pp. 7-13. doi: 10.11648/j.ajls.s.2015030104.12
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