Recognition of Acute Toxoplasmosis with IgG Avidity ELISA Test in the Pregnant Women (The First Trimester) in Qom Province, Iran, during Two Years (2012-2013)
American Journal of Life Sciences
Volume 2, Issue 6-3, December 2014, Pages: 18-21
Received: Dec. 5, 2014;
Accepted: Dec. 12, 2014;
Published: Dec. 27, 2014
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Mohammad Reza Haeri, School of medicine, Qom University of medical sciences, Qom, Ira
Behnaz Jalalizadegan, Department of Parasitology and Mycology, School of Medicine, Ira
Fatemeh Tabatabaie, Department of Parasitology and Mycology, School of Medicine, Ira
Toxoplasma gondii is an obligate intracellular protozoan parasite occurring with a global distribution. Congenital toxoplasmosis results when a non-immune woman gets a primary infection during pregnancy. Chronically infected women is not transmitted the infection to their offspring. The aim of this study was to perform IgG avidity test for detection of acute toxoplasmosis in the pregnant women (The first trimester). A total of 200 human serum samples were collected from different laboratories in Qom province. The anti-toxoplasma IgG, IgM and IgG avidity were evaluated by ELISA method. The samples were divided into 2 segregated groups: Group I consisted of 25 serum samples from patients in acute phase of Toxoplasma infection. All the pa¬tients had the symbol of lymphadenopathy. Group II consisted of 185 serum samples prepared from pa-tients in chronic phase of Toxoplasma infection. The data were analyzed by descriptive statistical methods. 20 out of 25 (80%) sera with acute toxoplasmosis showed low avidity levels and 178 out of 185 (96%) sera in chronic phase of infection showed high avidity index. 7sera had borderline ranges of AI. In this study, IgM ELISA and IgG avidity ELISA tests together could confirm the acute and chronic phases of disease completely. The IgG avidity test was created to help distinguish between past and recently acquired infection.
Mohammad Reza Haeri,
Recognition of Acute Toxoplasmosis with IgG Avidity ELISA Test in the Pregnant Women (The First Trimester) in Qom Province, Iran, during Two Years (2012-2013), American Journal of Life Sciences. Special Issue: Microbiology Research.
Vol. 2, No. 6-3,
2014, pp. 18-21.
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