American Journal of Life Sciences

| Peer-Reviewed |

Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.

Received: 12 August 2014    Accepted: 03 September 2014    Published: 17 September 2014
Views:       Downloads:

Share This Article

Abstract

Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.

DOI 10.11648/j.ajls.s.2014020601.13
Published in American Journal of Life Sciences (Volume 2, Issue 6-1, November 2014)

This article belongs to the Special Issue Recent Developments in Health Care through Plants and Microbes

Page(s) 11-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Plumeria, Antioxidant, Anticancer, Anti-Cholesterol, Colon Cancer

References
[1] Organization WH, WHO traditional medicine strategy 2002-2005 Geneva: World Health Organization; 2002
[2] R. Baskar, K.A. Lee, R. Yeo, K.W. Yeoh, “Cancer and radiation therapy: current advances and future directions,” Int J Med Sci., vol. 9, 193-199, 2012.
[3] D.J. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. vol. 75, 311-335, 2012.
[4] C. Li, M.H. Wang, “In vitro biological evaluation of 100 selected methanol extracts from the traditional medicinal plants of Asia,” Nutr Res Pract., vol.8, 151-157, 2014.
[5] D.S. Fabricant, N.R. Fransworth, “The value of plants used in traditional medicine for drug discovery,” Environ Health Perspect., vol. 109, 69-75, 2001.
[6] W. Zheng, S.Y. Wang, “Antioxidant activity and phenolic compounds in selected herbs,” J Agric Food Chem., vol. 49, 5165-5170, 2001.
[7] W.H. Frishman, “Biologic Markers as Predictors of Cardiovascular Disease,” Amer. J Med., vol. 104, 18S-27S, 1998.
[8] B.K. Rao, M.M. Kesavulu, R. Giri, C. Apparao, “Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook. fruit powder in alloxan diabetic rats,” J Ethnopharmacol., vol. 67, 103-109, 1999.
[9] B. Sharma, C. Balomajumder, P. Roy, “Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats,” Food Chem Toxicol., vol. 46, 2376-2383, 2008.
[10] Y.T. Liu, B.N. Lu, L.N. Xu, L.H. Yin, X.N. Wang, J.Y. Peng, K.X. Liu, “The antioxidant activity and hypolipidemic activity of the total flavonoids from the fruit of Rosa laevigata Michx,” Natural Science., vol. 2, 175-183, 2010.
[11] R.K. Goyal, G. Goyal, S. Goyal, S. Mittal, “Pharmacognostical evaluation of bark of Plumeria alba Linn,” International Journal of Natural Product Science, vol. 1, 178, 2012
[12] F. Edward, D.G. Gilman, Plumeria rubra Middle aged Frangipani. Fact Sheet ST-491. Watson, 1994.
[13] G. Sibi, Saurabh Awasthi, K. Dhananjaya, H. Mallesha and K.R. Ravikumar, Comparative studies of Plumeria species for their phytochemical and antifungal properties against Citrus sinensis pathogens. International Journal of Agricultural Research, vol. 7, 324-331, 2012.
[14] Rasool SN, Jaheerunnisa S, Chitta SK, Jayaveera KN. Antimicrobial activities of Plumeria acutifolia. J Med Plants Res. vol. 2, 77-80, 2008.
[15] R. Radha, T. Sivakumar, “In vitro and in vivo anti-cancer activity of leaves of Plumeria alba Linn,” J. Pharm. Res., vol. 2, 203-207, 2009.
[16] R. Radha, S. Kavimani, V. Ravichandran, “Antitumor activity of methanolic extract of Plumeria alba L. leaves against Dalton lymphoma ascites in mice, ” Int. J. Health Res., vol. 1, 79-85, 2009.
[17] J.B. Rekha, B. Jayakar, “Anticancer activity of ethanolic extract of leaves of Plumeria rubra (Linn.),” Current Pharma Tech, CPR1(2): 175-179, 2011.
[18] M.P. Dobhal, G. Li, A. Gryshuk, A. Graham, A.K. Bhatanager, S.D. Khaja, Y.C. Joshi, M.C. Sharma, A. Oseroff, R.K. Pandey, “Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity,” J Org Chem., vol. 69, 6165-6172, 2004.
[19] M. Gupta, U.K. Mazumder, P. Gomathi, “Evaluation of antipyretic and antiociceptive activities of Plumeria accuminata leaves,” J. Med. Sci, vol. 7, 835-839, 2007.
[20] A.J. Merina, D. Sivanesan, V.H. Begum, N. Sulochana, “Antioxidant and hypolipidemic effect of Plumeria rubra L. in alloxan induced hyperglycemic rats,” E-Journal of Chemistry, vol. 7,1-5, 2010.
[21] M.A. Gyamfi, M. Yonamine, Y. Aniya, “Free radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally induced liver injuries,” Gen Pharmacol, vol. 32, 661-667, 1999.
[22] E.A. Ainsworth, K.M. Gillespie, Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nature Protocols, vol. 2, 875-877, 2007.
[23] P. Prieto, M. Pineda, M. Aguilar M, “Spectrophotometric quantitation of antioxidant capacity through the formation of a Phosphomolybdenum Complex: Specific application to the determination of vitamin E,” Anal Biochem, vol. 269, 337-341, 1999.
[24] D. Iswantini, D. Nurenda dan, P. Sugita, “Fractionation and characterization of active compounds from Bangle (Zingiber Cassumunar Roxb.) as an activator of the enzyme cholesterol oxidase,” Simposium Nasional Kimia Bahan Alam XV. Himpunan Kimia Bahan Alam. Bogor., 2005
[25] Randox Laboratories, “Cholesterol (Chol) enzymatic endpoint method manual,” 2009.
[26] S.P.M. Crouch, R. Kozlowski, K.J. Slater, J. Fletcher, “The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity”. J. Immunol. Methods., vol. 160, 81-88, 1993.
[27] M. Henriques, A. Silva, J. Rocha. “Extraction and quantification of pigments from a marine microalga: a simple and reproducible method”. In: Mendez-Vilas A, editor. Communicating Current Research and Educational Topics and Trends in Applied Microbiology. Madrid: Formatex; pp. 586-593, 2007.
[28] V. Ani, K.A. Naidu, “Antioxidant potential of bitter cumin (Centratherum anthelminticum (L.) Kuntze) seeds in in vitro models,” BMC Complement Altern., vol. 13: 40, 2011.
[29] A.A. Mohamed, A.A. Khalil, H.E.S. El-Beltagi, “Antioxidant and antimicrobial properties of kaff maryam (Anastatica hierochuntica) and doum palm (Hyphaene thebaica)” Grasas Y Aceites. vol. 61, 67-75, 2010.
[30] M.J. Balunas, A.D. Kinghorn, “Drug discovery from medicinal plants,” Life Sci., vol. 78, 431-441, 2005.
[31] M. Gordaliza, “Natural products as leads to anticancer drugs,” Clin Transl Oncol vol. 9, 767-776, 2007.
[32] A.G. Desai, G.N. Qazi, R.K. Ganju, M. El-Tamer, J. Singh, A.K. Saxena, Y.S. Bedi, S.C. Taneja, H.K. Bhat, “Medicinal plants and cancer chemoprevention. Curr Drug Metab,” vol. 9, 581-591, 2008.
[33] J.C. Fruchart, P. Duriez, “High density lipoproteins and coronary heart disease future prospects in gene therapy,” Biochimie, vol. 80, 167-172, 1998.
Author Information
  • Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

  • Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

  • Department of Microbiology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

  • Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

  • Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

  • Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA

Cite This Article
  • APA Style

    Hafizur Rahman, Vijaya Badra Reddy, Soumya Ghosh, Sandeep Kumar Mistry, Geetika Pant, et al. (2014). Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. American Journal of Life Sciences, 2(6-1), 11-15. https://doi.org/10.11648/j.ajls.s.2014020601.13

    Copy | Download

    ACS Style

    Hafizur Rahman; Vijaya Badra Reddy; Soumya Ghosh; Sandeep Kumar Mistry; Geetika Pant, et al. Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. Am. J. Life Sci. 2014, 2(6-1), 11-15. doi: 10.11648/j.ajls.s.2014020601.13

    Copy | Download

    AMA Style

    Hafizur Rahman, Vijaya Badra Reddy, Soumya Ghosh, Sandeep Kumar Mistry, Geetika Pant, et al. Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. Am J Life Sci. 2014;2(6-1):11-15. doi: 10.11648/j.ajls.s.2014020601.13

    Copy | Download

  • @article{10.11648/j.ajls.s.2014020601.13,
      author = {Hafizur Rahman and Vijaya Badra Reddy and Soumya Ghosh and Sandeep Kumar Mistry and Geetika Pant and Sibi G.},
      title = {Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.},
      journal = {American Journal of Life Sciences},
      volume = {2},
      number = {6-1},
      pages = {11-15},
      doi = {10.11648/j.ajls.s.2014020601.13},
      url = {https://doi.org/10.11648/j.ajls.s.2014020601.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.s.2014020601.13},
      abstract = {Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.},
     year = {2014}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.
    AU  - Hafizur Rahman
    AU  - Vijaya Badra Reddy
    AU  - Soumya Ghosh
    AU  - Sandeep Kumar Mistry
    AU  - Geetika Pant
    AU  - Sibi G.
    Y1  - 2014/09/17
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajls.s.2014020601.13
    DO  - 10.11648/j.ajls.s.2014020601.13
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 11
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.s.2014020601.13
    AB  - Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.
    VL  - 2
    IS  - 6-1
    ER  - 

    Copy | Download

  • Sections