In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata
American Journal of Life Sciences
Volume 2, Issue 6-1, November 2014, Pages: 7-10
Received: Aug. 13, 2014; Accepted: Aug. 15, 2014; Published: Aug. 24, 2014
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Authors
Hafizur Rahman, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Vijaya B, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Soumya Ghosh, Department of Microbiology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Geetika Pant, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
Sibi G, Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, INDIA
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Abstract
New drug preparations of natural origin are in need due to the numerous side effects and resistance development through the continuous and uncontrolled use of synthetic drugs. Lichens are reported to have manifold biological activities and in this study, antioxidant, hypolipidemic and cytotoxic potential of Parmelia perlata were assessed. Methanolic extract of P. perlata was prepared and used in DPPH assay, total phenolic content and total antioxidant potential assays. In vitro anti-cholesterol and cytotoxic assay using HCT 116 cell lines were performed. The results revealed that P. perlata contain high phenolic contents and antioxidant potential. Simvastatin was used as standard drug and the extracts demonstrated 48% anti-cholesterol activity. MTT assay using colon cancer cell lines (HCT 116) produced dose dependent cytotoxic effect with an IC50 value of 202.1 µg ml-1.
Keywords
Parmelia Perlata, Antioxidant, Anticancer, Anti-Cholesterol, Colon Cancer
To cite this article
Hafizur Rahman, Vijaya B, Soumya Ghosh, Geetika Pant, Sibi G, In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata, American Journal of Life Sciences. Special Issue:Recent Developments in Health Care through Plants and Microbes. Vol. 2, No. 6-1, 2014, pp. 7-10. doi: 10.11648/j.ajls.s.2014020601.12
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