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Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats
American Journal of Life Sciences
Volume 8, Issue 5, October 2020, Pages: 96-101
Received: Apr. 2, 2020; Accepted: May 18, 2020; Published: Aug. 27, 2020
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Authors
Ibrahim Maina Hassan, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Bashir Saidu, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ja’afaru Abdullahi Ishaq, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ashiru Dahiru, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Nafisat Abdulazeez, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Halima Ibrahim Yusuf, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Jubril Saidu Fatima, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Yushau Shuaibu Baraya, Department of Veterinary Pathology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Adamu Abdul Abubakar, Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Adama Musa Abdullahi, Department of Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
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Abstract
Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This study was conducted to know the effect of Moringa oleifera leaf on Serum biochemistry of experimental exposed Wister rats. Moringa oleifera leaf was extracted with distilled water and concentrated to semisolid form with rotary evaporator at 42°C. Twenty apparently healthy rats weighing 128-233g were exposed to different concentration of Moringa oleifera aqueous leaf extract. Control group were exposed to only distill water. The animals were divided into 3 groups of five rats each, with Group-I exposed to 500 mg/kg crude extract. Group-II exposed to 1000 mg/kg crude extract and Group-III exposed to 2000 mg/kg crude extract. There significant difference (p< 0.05) in analyzed serum biochemical parameters (Creatinine, Urea, Aspartate amino transferase and Alanine amino transferase) between the experimental and control group. From this finding, it can be concluded that Moringa oleifera leaf extract up to 2000mg/kg is safe and cause slight changes in serum biochemistry. Toxicity studies of this plant extracts as well as phytochemical studies to reaffirm it effect in several body tissues and organs and identify the bioactive compounds are highly recommended.
Keywords
Alanine Amino Transferase, Aqueous, Aspartate Amino Transferase, Concentration, Creatinine, Moringa oleifera, Urea
To cite this article
Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, Halima Ibrahim Yusuf, Jubril Saidu Fatima, Yushau Shuaibu Baraya, Adamu Abdul Abubakar, Adama Musa Abdullahi, Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats, American Journal of Life Sciences. Vol. 8, No. 5, 2020, pp. 96-101. doi: 10.11648/j.ajls.20200805.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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