Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor
American Journal of Life Sciences
Volume 3, Issue 4, August 2015, Pages: 311-315
Received: Jun. 15, 2015;
Accepted: Jul. 11, 2015;
Published: Jul. 18, 2015
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Md. Rafiqul Islam Khan, Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan; Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Takashi Yazawa, Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan
Junsuke Uwada, Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan
Abu Syed Md. Anisuzzaman, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh; Department of Hematology & Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA
Takanobu Taniguchi, Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan
Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.
Md. Rafiqul Islam Khan,
Abu Syed Md. Anisuzzaman,
Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor, American Journal of Life Sciences.
Vol. 3, No. 4,
2015, pp. 311-315.
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