Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile
American Journal of Life Sciences
Volume 3, Issue 1, February 2015, Pages: 6-10
Received: Dec. 12, 2014;
Accepted: Dec. 22, 2014;
Published: Jan. 20, 2015
Views 2802 Downloads 174
Rajib Dab Nath, Department of Pharmacy, Noakhali Science & Technology University, Noakhali, Bangladesh
Md. Sohel Rana, Department of Pharmacy, Jahangirnagar University, Dhaka, Bangladesh
Md. Areeful Haque, Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh
Pobittro Sen, Department of Pharmacy, Stamford University, Dhaka, Bangladesh
Md. Elias Mehedy, Department of Microbiology, University of Chittagong, Chittagong, Bangladesh
Mrityunjoy Biswas, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
In this investigation we included an extraction of Borassusflabilifer root and reported to have beneficial effect in lowering of blood pressure and treatment of hypertensive patients. Borassusflabilifer root were collected from various part of Noakhali and extract was prepared by following standard method. The present study was conducted to determine the in vivo effect of Borassusflabilifer root extract on tissues and serum lipids in experimental rats. 15 male Wistar rats were randomly divided into 3 groups and administered different doses of the extract for 30 days while control group received distilled water. Lipid profile in the serum, liver, kidney and heart of the experimental animals were measured and compared with the control. Borassusflabilifer caused significant (p<0.0) reduction in serum total cholesterol and LDL cholesterol in a dose dependent manner in rats while serum HDL cholesterol was significantly elevated. Serum triglyceride level was not significantly affected. There was also a significant increase in the levels of total cholesterol and triglyceride in the liver while lipid profile in the heart and Kidney were unaffected. This result suggests positive alterations in lipid metabolism and storage in rats which corroborate the efficacy of Borassusflabilifer root extract in the management of atherosclerosis caused by lipid abnormalities. We can develop techniques on rational design of drug for the treatment of heart diseases and further study can lead to the development of a therapy for other diseases like diabetes.
Rajib Dab Nath,
Md. Sohel Rana,
Md. Areeful Haque,
Md. Elias Mehedy,
Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile, American Journal of Life Sciences.
Vol. 3, No. 1,
2015, pp. 6-10.
Ghani A. 2003. Medicinal Plants of Bangladesh: Chemical Constituents and Uses. 2nd Ed. The Asiatic society of Bangladesh, Dhaka, Bangladesh, pp. 7, 74-76, 99, 115, 117-118,161, 217,226, 276, 315, 328, 365, 367, 402, 428, 430, 433-434, 525-526, 528-530.
Ariyasena D. D., Jansz, E. R., Jayesekera s., Abesekara A. M. 2000. J. Sci. Food Agric., 80:1763-1766.
Halliwell B., Gutteridge J. M.C., 1984. Free Radical in Biology and Medicine. Oxford, Oxford University Press.
Cragg G. M., Newan D. j., 2005. Plants as source of anticancer agents. J Ethnopharmacol., 100: 72-79.
Balunas M.J., Kinghorn A. D., 2005. Drug Discovery from medicinal plants. Life Sci., 78:431-441. Kimura Y., 2005. New anticancer agents: in Vitro and in Vivo evaluation of the antitumor and antimetastatic action of various compounds isolated from medicinal plants. In Vivo.,19: 37-60.
Dulger B., Celikler S., Kirmizi S., 1998. Antimicrobial activity of hyper Perforratum(L). KUKEM Dergisi, 21: 33-40, Ahmed I., Beg A. Z., 2001. Antimicrobial and phytochemical Studies on 45 Indian medicinal plants againist multi-drug resistant human pathogens. J. Enthopharmacpl., 74:113-123, Lopez A., Hudson J. B., Towers G. H. N., 2001. Antimicrobial activities of Colombian medicinal plants. J. Ethnopharmacol., 77: 189-196.
Vermani K., Grag S., 2002. Herbal medicines for sexually transmitted diseases and AIDS. J. Ethanopharmacol., 80: 49-66.
Cragg G. M., Newman D. J. Sanders K. M., 1997. Natural products in drug discovery and development. J. Nat. Prod.,60: 52-60.
F. Zoppi, D Fellini, Clin. Chem., 1976, 22, 690-691.
Trinder, Ann. Clin. Biochem., 1969, 6, 24-27.
WT Friedwald, RI Levy, DS Fredrickson, Clin. Chem., 1972, 18, 499-502.
FV Udoh, Fitoterapia, 1998, 69 (2), 141-146.
FC Zhan, PJ Casey, Annual Rev. Biochem., 1996, 65, 241-246.
KH Bopanna, J Kannan, S Gadgil, ER Balaraman, SP Rathore, Indian Journal of [Pharmacology, 1997, 29, 162-167.
GL Vega, MF Weiner, AM Lipton, Arch Neurol., 2003, 60, 510-515.