Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats
American Journal of Life Sciences
Volume 2, Issue 5, October 2014, Pages: 308-311
Received: Oct. 16, 2014; Accepted: Oct. 27, 2014; Published: Oct. 30, 2014
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Authors
Ajayi Olubunmi Bolanle, Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria
Malachi Oluwaseyi Israel, Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria
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Abstract
Twenty four male rats weighing between 120-130g were randomly assigned into four groups. Group A was fed normal diet; Group B, C and D were fed hypercholesterolemic diet (i.e. 20% fat + 1% cholesterol) for two weeks to establish hypercholesterolemia. Thereafter, Group B were maintained on hyper diet, while C and D were fed 5% and 10% Sesamum indicum seed oil supplemented diet for four weeks. The liver and kidney were removed, dried and powdered. The concentrations of iron, zinc, cobalt, manganese, calcium, potassium, magnesium, potassium and sodium were analyzed in both liver and kidney samples with the use of Atomic Absorption Spectrophotometry. Hypercholesterolemia reduced both the hepatic and renal concentrations of sodium, potassium, Phosphorus, magnesium and calcium but reduced the hepatic and not the renal concentrations of manganese and zinc. Supplementation with 5% but not 10% Sesamum indicum seed oil reversed the effects and restored the reduced ions concentrations. The hepatic and renal concentrations of Iron and Cobalt ions were not affected by hypercholesterolemia nor by supplementation with Sesamum indicum seed oil.
Keywords
Hypercholesterolemia, Sesamum Indicum, Liver, Kidney, Mineral Concentration
To cite this article
Ajayi Olubunmi Bolanle, Malachi Oluwaseyi Israel, Effect of Sesamum indicum L. Seed oil Supplementation on Hepatic and Renal Mineral Concentrations of Hypercholesterolemic Rats, American Journal of Life Sciences. Vol. 2, No. 5, 2014, pp. 308-311. doi: 10.11648/j.ajls.20140205.19
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