European Journal of Biophysics

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pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study

Received: 21 October 2020    Accepted: 07 November 2020    Published: 19 November 2020
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Abstract

This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.

DOI 10.11648/j.ejb.20200802.16
Published in European Journal of Biophysics (Volume 8, Issue 2, December 2020)
Page(s) 52-59
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Emulsion, Pickering, Nanoparticles, Hydroxyapatite, Oral Bioavailability

References
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Author Information
  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of biopharmacy, Health Training and Research Unit, Thies University, Thies, Senegal

  • Department of Pharmacy, Service of Medical Biophysics, Health Training and Research Unit, Thies University, Thies, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Medicine, Laboratory of Medical Biophysics and Nuclear Medicine, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Pharmacy, Laboratory of Pharmaceutical Physics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

Cite This Article
  • APA Style

    Papa Mady Sy, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Sidy Mouhamed Dieng, Mamadou Soumboundou, et al. (2020). pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. European Journal of Biophysics, 8(2), 52-59. https://doi.org/10.11648/j.ejb.20200802.16

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    ACS Style

    Papa Mady Sy; Louis Augustin Diaga Diouf; Alphonse Rodrigue Djiboune; Sidy Mouhamed Dieng; Mamadou Soumboundou, et al. pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. Eur. J. Biophys. 2020, 8(2), 52-59. doi: 10.11648/j.ejb.20200802.16

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    AMA Style

    Papa Mady Sy, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Sidy Mouhamed Dieng, Mamadou Soumboundou, et al. pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study. Eur J Biophys. 2020;8(2):52-59. doi: 10.11648/j.ejb.20200802.16

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  • @article{10.11648/j.ejb.20200802.16,
      author = {Papa Mady Sy and Louis Augustin Diaga Diouf and Alphonse Rodrigue Djiboune and Sidy Mouhamed Dieng and Mamadou Soumboundou and Cecile Diop and Toro Diop and Gora Mbaye and Mamadou Mbodj and Mounibe Diarra},
      title = {pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study},
      journal = {European Journal of Biophysics},
      volume = {8},
      number = {2},
      pages = {52-59},
      doi = {10.11648/j.ejb.20200802.16},
      url = {https://doi.org/10.11648/j.ejb.20200802.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ejb.20200802.16},
      abstract = {This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study
    AU  - Papa Mady Sy
    AU  - Louis Augustin Diaga Diouf
    AU  - Alphonse Rodrigue Djiboune
    AU  - Sidy Mouhamed Dieng
    AU  - Mamadou Soumboundou
    AU  - Cecile Diop
    AU  - Toro Diop
    AU  - Gora Mbaye
    AU  - Mamadou Mbodj
    AU  - Mounibe Diarra
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    T2  - European Journal of Biophysics
    JF  - European Journal of Biophysics
    JO  - European Journal of Biophysics
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    EP  - 59
    PB  - Science Publishing Group
    SN  - 2329-1737
    UR  - https://doi.org/10.11648/j.ejb.20200802.16
    AB  - This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.
    VL  - 8
    IS  - 2
    ER  - 

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