Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues
European Journal of Biophysics
Volume 7, Issue 2, December 2019, Pages: 27-42
Received: Jul. 19, 2019;
Accepted: Aug. 15, 2019;
Published: Aug. 29, 2019
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Lilia Narinyan, Life Sciences International Postgraduate Educational Center, Unesco Chair in Life Sciences, Yerevan, Armenia
Sinerik Ayrapetyan, Life Sciences International Postgraduate Educational Center, Unesco Chair in Life Sciences, Yerevan, Armenia
The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na+/Ca2+ Exchanger in Brain Cortex Tissues, European Journal of Biophysics.
Vol. 7, No. 2,
2019, pp. 27-42.
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