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Case Report
Scurvy in Children: A Case Report
Siham Satlane*
,
Imane Chahid,
Fatima Harim,
Meriem Atrassi,
Dalal Bensabbahia,
Abdelhak Abkari
Issue:
Volume 10, Issue 2, June 2024
Pages:
48-51
Received:
4 March 2024
Accepted:
20 March 2024
Published:
2 April 2024
DOI:
10.11648/j.ajp.20241002.11
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Abstract: Scurvy is all the symptoms associated with a diet deficient in ascorbic acid or vitamin C, found in fresh fruit and vegetables. Scurvy is a pathology resulting from a deep and prolonged vitamin C deficiency, which can manifest itself as a bleeding syndrome, wound healing disorders, rheumatic signs, or gum damage. If left untreated (vitamin C supplementation), the disease can be fatal. This water-soluble vitamin is neither synthesized nor stored in the body. In recent years, there has been a resurgence of this pathology due to unbalanced nutrition. Clinical presentations are deceptive and variable, with orthopedic abnormalities and a diffuse hemorrhagic syndrome secondary to a defect in collagen fiber synthesis in children. The diagnosis of scurvy is confirmed by measuring ascorbemia, which is less than 2 mg/L (5-15 mg/L or 17-94 mmol/L), and treatment is based on vitamin C supplementation at 100 to 300 mg/day until complete recovery. We report the case of a 7-year-old patient with an autistic spectrum disorder associated with epilepsy, who presented with scurvy revealed by bone involvement consisting of bone pain, a bleeding syndrome and gingival hypertrophy in context of altered general condition. The diagnosis was confirmed by a collapsed ascorbic acid level (<3 mmol/l) and progressed favorably on vitamin supplementation.
Abstract: Scurvy is all the symptoms associated with a diet deficient in ascorbic acid or vitamin C, found in fresh fruit and vegetables. Scurvy is a pathology resulting from a deep and prolonged vitamin C deficiency, which can manifest itself as a bleeding syndrome, wound healing disorders, rheumatic signs, or gum damage. If left untreated (vitamin C supple...
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Research Article
Epidemiology of and Factors Associated with Helicobacter Pylori Infection and Proportion Requiring Treatment Among Symptomatic Children in Northwestern Tanzania
Mwanaidi Mkwizu*,
Hyasinta Jaka,
Stephen Mshana,
David Majinge,
Igembe Nkandala,
Delfina Msanga,
Tulla Masoza,
Benson Kidenya,
Elig Kimosso,
Neema Kayange
Issue:
Volume 10, Issue 2, June 2024
Pages:
52-62
Received:
23 February 2024
Accepted:
19 March 2024
Published:
11 April 2024
DOI:
10.11648/j.ajp.20241002.12
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Abstract: Background: Helicobacter pylori infection has been reported to affect more than half of the global population. The persistence of H. pylori infection results to chronic gastritis and peptic ulcer disease. Despite this burden there is limited published studies regarding proportion of Helicobacter pylori infected children that require treatment in many settings in low and middle-income countries (LMICs). Therefore this study aimed to determine the epidemiology of and factors associated with Helicobacter pylori infection and proportion requiring treatment among symptomatic children in northwestern Tanzania. Methodology: This was a hospital based cross-sectional study conducted at BMC hospital in Northwestern Tanzania from December 2021 and April 2022 among outpatient children aged 1 to 15 years with gastrointestinal symptoms. The main study outcome (event) was presence of H. pylori infection as evidence by positive stool antigen test. Independent factors associated with H. pylori infection were determined by logistic regression model. The significance level was set at p-value of <0.05. Oesophagogastroduodenoscopy (OGD) was performed to the randomly serially selected representative sample of symptomatic children with positive H. pylori stool antigen test to determine the proportion of children requiring treatment. Results: A total of 422 symptomatic children were included in the study. The median age was 7 [IQR 3 – 10] years. The prevalence of H. pylori infection was 105 (24.9%). More than half of the participants (56.4%) were males. The risk of H. pylori infection was significantly associated with increase in age (OR= 1.09; 95%CI; 1.03 – 1.15; P= 0.002), and abdominal pain (OR=2.2; 95%CI 1.2 – 4.0; P= 0.01). About 55 participants were randomly selected for OGD among 100 children above or equal 2 years of age with positive stool antigen for H. pylori. The majority were found to have lesion warranting treatment. These lesions included gastritis 47 (85.5%), duodenal ulcers 2 (3.6%) and gastric ulcers 1 (1.8%). Conclusion: About a quarter of the enrolled children had H. pylori infection. Increase in age and abdominal pain were independently associated with H. pylori infection. Most H. pylori stool antigen test positive children had endoscopic lesions that warranted treatment. Therefore every H. pylori stool antigen test positive child needs eradication therapy.
Abstract: Background: Helicobacter pylori infection has been reported to affect more than half of the global population. The persistence of H. pylori infection results to chronic gastritis and peptic ulcer disease. Despite this burden there is limited published studies regarding proportion of Helicobacter pylori infected children that require treatment in ma...
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Research Article
Factors Associated with Drug Use Among Secondary and High School Adolescents
Mekone Nkwele Isabelle*,
Menguene Justine Laure,
Abada Siméone Carelle,
Kamo Hélène Selangai,
Elong Jules Thierry,
Meguieze Claude Audrey,
Epee Ngoué Jeannette,
Nsoh Ndeh-Fofang,
Nguefack Séraphin
Issue:
Volume 10, Issue 2, June 2024
Pages:
63-68
Received:
15 March 2024
Accepted:
27 March 2024
Published:
11 April 2024
DOI:
10.11648/j.ajp.20241002.13
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Abstract: Introduction: Drug abuse is a significant public health concern among adolescents, who are a very susceptible group. This study aimed to identify the various factors associated with drug use among adolescents in secondary school. Methodology: Between October 2022 and April 2023, a cross-sectional and analytical study was carried out among adolescents in fourteen secondary schools in the city of Yaoundé, the administrative capital of Cameroon. The sampling was consecutive and non-exhaustive. The SPSS software version 23.0 was used for data analysis. Multivariate analysis was achieved using the logistic regression model. An Odd Ratio with a 95% confidence interval was used to establish associated factors. The association between categorical variables was measured using Chi-square and Fisher's exact tests (p < 0.05). Results: Of the 1987 adolescents included, the prevalence of drug use was 27.5%, i.e. 546 pupils with an average age of 16.9 ± 1.4 years. The prevalence of drug use in the study was 27.5%. The risk factors identified were students aged 15 to 18, being in the first and final year of secondary school, being raised by either their father or grandparents only and having a bar at home. The protective factor was the absence of drug use by a household member. Conclusion: The high prevalence of drug use among teenagers at school means that preventive measures need to be instilled for school health and the community.
Abstract: Introduction: Drug abuse is a significant public health concern among adolescents, who are a very susceptible group. This study aimed to identify the various factors associated with drug use among adolescents in secondary school. Methodology: Between October 2022 and April 2023, a cross-sectional and analytical study was carried out among adolescen...
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Research Article
Diagnostic Value of Faecal Calprotectin in Children with Chronic Gastrointestinal Disorders at Yaounde General Hospital
Mekone Nkwele Isabelle*,
Ngo Libii Li Ntep Marguerite Audrey,
Nkeck Jériel Pascal,
Epée Ngoué Jeannette,
Ngogang Marie Paul,
Nguefack Félicité,
Ama Moor Vicky Jocelyne
Issue:
Volume 10, Issue 2, June 2024
Pages:
69-74
Received:
18 March 2024
Accepted:
1 April 2024
Published:
11 April 2024
DOI:
10.11648/j.ajp.20241002.14
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Abstract: Introduction: Chronic gastrointestinal disorders are common in children. Numerous faecal biomarkers, such as faecal calprotectin, are used in the aetiological diagnosis of these digestive disorders. The study aimed to investigate the diagnostic value of faecal calprotectin in paediatric chronic gastrointestinal disease compared with that obtained in healthy children. Methodology: This was a comparative, analytical cross-sectional study from October 2022 through June 2023 at Yaoundé General Hospital. Participants were children aged between four and eighteen with chronic digestive disorders. Using a pre-established questionnaire, we collected the socio-demographic and clinical characteristics of each participant. The participants' faecal calprotectin was tested at the laboratory of the Yaoundé University Hospital Center by Enzyme-Linked Immunosorbent Assay (ELISA). Associations between variables were investigated by linear regression and calculation of the odds ratio (OR). The significance threshold was 5%. Results: Sixty stool samples were analysed for faecal calprotectin from 30 patients and 30 healthy participants. The mean age of the population was 9.47 (± 3.35) years for patients and 10.67 (± 3.70) years for healthy participants, with a sex ratio of 1.14 for patients and 0.87 for healthy participants. The threshold value for faecal calprotectin was 2.75 µg/g, with a sensitivity of 60%, a specificity of 63%, a positive predictive value of 61.20% and a negative predictive value of 62.06%. There were no significant differences in faecal calprotectin concentrations between children with chronic gastrointestinal disorders (peptic ulcer disease: p=0.10; functional gastrointestinal disorder associated with peptic ulcer disease: p= 0.710; functional gastrointestinal disorder: p= 0.143) and healthy children. Conclusion: The diagnostic value of faecal calprotectin as a biomarker in the diagnosis of chronic gastrointestinal disease was not observed in this study. However, the biological parameters assessed were measured only once, and given that their concentrations may vary over time, we recommend a subsequent longitudinal study.
Abstract: Introduction: Chronic gastrointestinal disorders are common in children. Numerous faecal biomarkers, such as faecal calprotectin, are used in the aetiological diagnosis of these digestive disorders. The study aimed to investigate the diagnostic value of faecal calprotectin in paediatric chronic gastrointestinal disease compared with that obtained i...
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