Journal of Drug Design and Medicinal Chemistry

Volume 5, Issue 4, December 2019

  • In Silico Docking Analysis of A-type Proanthocyanidins to α-Glucosidase Constructed by Correlation with in Vitro Bioassay

    Sheau Ling Ho, Yili Lin, Shengfa Tsai, Shoeisheng Lee

    Issue: Volume 5, Issue 4, December 2019
    Pages: 47-60
    Received: 21 November 2019
    Accepted: 7 December 2019
    Published: 23 December 2019
    Downloads:
    Views:
    Abstract: The type A proanthocyanidins (2−8) with (2β→O→7, 4β→8) interflavane linkage, isolated from Machilus philippinensis, have been found to possess inhibitory activity against α-glucosidase (EC 3.2.1.20 from Bacillus stearothermophilus). To rationalize such activity, computer assisted docking of these compounds and the positive control, acarbose, on the... Show More
  • Source Tracking and Carcinogenic Risk of Polycyclic Aromatic Hydrocarbons in Contaminated Farmlands of Egi, Niger Delta, Nigeria

    Elechi Owhoeke, Michael Horsfall Jnr, Charles Ikenna Osu

    Issue: Volume 5, Issue 4, December 2019
    Pages: 61-66
    Received: 20 October 2019
    Accepted: 4 November 2019
    Published: 6 January 2020
    Downloads:
    Views:
    Abstract: The levels of Polycyclic Aromatic Hydrocarbons (PAHs) in contaminated farmland soil from three oil-producing communities (Oboburu, Obagi, and Ogbogu) in Egi, Niger Delta were assessed for variability, origin and health risks. The result showed that tPAHs of Oboburu were 1344±1685 mg/kg for carcinogenic while BaP (257.3±270.5 mg/kg) had the greatest... Show More