Journal of Drug Design and Medicinal Chemistry

Volume 5, Issue 2, June 2019

  • Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug

    Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki

    Issue: Volume 5, Issue 2, June 2019
    Pages: 18-25
    Received: 29 May 2019
    Accepted: 10 July 2019
    Published: 6 August 2019
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    Abstract: In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls.... Show More
  • Development of Co-processed Paracetamol with Hydroxypropyl Methylcellulose (HPMC) and Maltodextrin by Wet Granulation Process

    Ortega Leticia, Gómez Martín, Daniela Rodríguez

    Issue: Volume 5, Issue 2, June 2019
    Pages: 26-32
    Received: 5 July 2019
    Accepted: 22 July 2019
    Published: 7 August 2019
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    Abstract: The purpose of this work is to improve one of the important physicochemical properties of an active pharmaceutical ingredient (API), as is the water solubility of paracetamol. To improve the physicochemical properties of this API, two pharmaceutical excipients such as the HPMC and maltodextrin were used, which help to improve the solubility, and th... Show More