Journal of Drug Design and Medicinal Chemistry

Volume 2, Issue 5, October 2016

  • Combinations of Carbapenem with Fluoroquinolones or 1,3,4 -Oxadiazole-2 -Thione Derivatives as New Broad Spectrum Bactericidal Antibiotics for Ophthalmic Preparation

    Noor A. Waheed, Hashim J. Azeez, Faris T. Abachi

    Issue: Volume 2, Issue 5, October 2016
    Pages: 47-50
    Received: 27 August 2016
    Accepted: 12 October 2016
    Published: 14 October 2016
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    Abstract: The present work describes the preparation and evaluation of an ophthalmic eye drops of antibacterial agent. The active ingredients (mereopenem, fluoroquinolones & 1,3,4 oxadiazole -2-thione derivatives) have been used in the formulation as eye drops with different doses as broad spectrum antibiotics to minimize the emergence of resistance lesion s... Show More
  • Silver-Catalyzed Oxidation of Atropine Drug by Cerium(IV) in Aqueous Perchlorate Solutions: A Kinetics and Mechanistic Approach

    Ahmed Fawzy, Ishaq A. Zaafaray, Ismail I. Althagafi, Hatem M. Altass

    Issue: Volume 2, Issue 5, October 2016
    Pages: 51-59
    Received: 28 August 2016
    Accepted: 12 October 2016
    Published: 21 October 2016
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    Abstract: The kinetics of oxidation of atropine drug (ATR) by cerium(IV) in aqueous perchlorate solutions in the presence of silver(I) catalyst has been studied spectrophotometrically at a constant ionic strength and temperature. The reaction showed first order dependence with respect to each [Ce(IV)] and [Ag(I)], and less than unit order kinetics with respe... Show More