Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution
Dennis Oju Allagoa,
Benjamin Onyema Eledo,
Kingsley Excel Dunga,
Sylvester Chibueze Izah
Issue:
Volume 2, Issue 2, December 2018
Pages:
24-27
Received:
22 September 2018
Accepted:
5 October 2018
Published:
7 November 2018
DOI:
10.11648/j.ijg.20180202.11
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Abstract: This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.
Abstract: This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 ...
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Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis
Mohammed Abdelrahim Hassan,
Amin Mohammed Abass,
Hyder Osman Mirghani,
Elkhawad Osman,
Mohammed Osman Elhassan Gadour
Issue:
Volume 2, Issue 2, December 2018
Pages:
28-33
Received:
30 October 2018
Accepted:
13 November 2018
Published:
19 December 2018
DOI:
10.11648/j.ijg.20180202.12
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Abstract: Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.
Abstract: Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at I...
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