Modern Chemistry

Volume 1, Issue 1, February 2013

  • Synthesis, in vitro Anticancer Activity Evaluation and Docking Investigations of Novel Aromatic Chalcones

    Vankadari Srinivasarao, Chaturvedula Radha Krishna, Macha Ramesh, Tigulla Parthasarathy

    Issue: Volume 1, Issue 1, February 2013
    Pages: 1-7
    Received: 26 November 2012
    Accepted:
    Published: 20 February 2013
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    Abstract: In a wide search program toward new anticancer agents, a series of Aromatic chalcones have been synthesized by condensing benzaldehyde derivatives with arylmethylcetone in potassium hydroxide ethanol according to the Claisen-Schmidth condensation at room temperature. The synthetic chalcones have been determined by IR spectroscopy and 1H-NMR spectro... Show More
  • QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives

    Shanthi V., Ramesh M., Srimai V., Srinivas P., Parthasarathy T.

    Issue: Volume 1, Issue 1, February 2013
    Pages: 8-17
    Received: 29 November 2012
    Accepted:
    Published: 20 February 2013
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    Abstract: Invitro antioxidant activity and Molecular modeling studies of nine chromone derivatives were carried out to optimize their inhibitory activity against Poly [ADP-ribose] polymerase. The biological activities of these analogs were correlated to different molecular properties. The AM1and PM3 semiempirical methods are used to estimate vertical ioniza-... Show More