Advances in Biochemistry

Volume 4, Issue 4, August 2016

  • Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP

    Victoria V. Sokolik, Pavel A. Karpov, Dariya A. Samofalova, Sergiy M. Shulga

    Issue: Volume 4, Issue 4, August 2016
    Pages: 34-46
    Received: 19 May 2016
    Accepted: 02 June 2016
    Published: 20 June 2016
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    Abstract: Since it has been shown that Alzheimer’s disease is accompanied by higher peripheral concentrations of cytokines, we focused on the correction of chronic inflammation causing Aβ excess and aggregation what should have a positive impact. Proinflammatory cytokines action is realized by NF-κB intracellular signals. Curcumin can inhibit activation of t... Show More
  • Isolation, Partial Purification and Characterization of Polyphenol Oxidase from Two Species of African Mango Seeds (Irvingia gabonensis and Irvingia wombolu)

    David Morakinyo Sanni

    Issue: Volume 4, Issue 4, August 2016
    Pages: 47-52
    Received: 16 May 2016
    Accepted: 26 May 2016
    Published: 30 June 2016
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    Abstract: Polyphenol oxidases are oxido-reductases that catalyses oxidation of phenolic compounds in the presence of oxygen to form corresponding quinone intermediates which spontaneously polymerize to form undesirable pigments. Polyphenol oxidase was isolated and characterized in Irvingia species (gabonensis and wombolu) kernel, a tropical African fruit. Ex... Show More