Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential.
| Published in | Science Frontiers (Volume 4, Issue 2) |
| DOI | 10.11648/j.sf.20230402.11 |
| Page(s) | 17-24 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Liquisolid Technique, Solubility, Bioavailability, Non-Volatile Solvents, Drug Release
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APA Style
Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule. (2023). A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Science Frontiers, 4(2), 17-24. https://doi.org/10.11648/j.sf.20230402.11
ACS Style
Andrew Chekwube Ezegbe; Grace Amarachi Ezegbe; Josephat Ikechukwu Ogbonna; Sabinus Ifeanyi Ofoefule. A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Sci. Front. 2023, 4(2), 17-24. doi: 10.11648/j.sf.20230402.11
AMA Style
Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule. A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Sci Front. 2023;4(2):17-24. doi: 10.11648/j.sf.20230402.11
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Download@article{10.11648/j.sf.20230402.11,
author = {Andrew Chekwube Ezegbe and Grace Amarachi Ezegbe and Josephat Ikechukwu Ogbonna and Sabinus Ifeanyi Ofoefule},
title = {A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs},
journal = {Science Frontiers},
volume = {4},
number = {2},
pages = {17-24},
doi = {10.11648/j.sf.20230402.11},
url = {https://doi.org/10.11648/j.sf.20230402.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sf.20230402.11},
abstract = {Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential.},
year = {2023}
}
TY - JOUR T1 - A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs AU - Andrew Chekwube Ezegbe AU - Grace Amarachi Ezegbe AU - Josephat Ikechukwu Ogbonna AU - Sabinus Ifeanyi Ofoefule Y1 - 2023/07/06 PY - 2023 N1 - https://doi.org/10.11648/j.sf.20230402.11 DO - 10.11648/j.sf.20230402.11 T2 - Science Frontiers JF - Science Frontiers JO - Science Frontiers SP - 17 EP - 24 PB - Science Publishing Group SN - 2994-7030 UR - https://doi.org/10.11648/j.sf.20230402.11 AB - Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential. VL - 4 IS - 2 ER -
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