Bridelia ferruginea is a plant commonly used in several regions of the world for its various properties. It is offered to certain patients with cerebrovascular accidents. It is with this in mind that this study is undertaken in order to verify whether B. ferruginea has an activity on blood coagulation. Materiel and method: Stem bark of B. ferruginea was collected at Noepe (24 km northwest of Lome). Hydroalcoholic extract (50/50) was obtained by evaporation. Male Wistar rats were used for the tests. Qualitative screening was done according to conventional methods and total phenols were quantified. Some parameters of coagulation (blood platelets, aPTT, PR and fibrinogen) were determined. Oxidative stress was induced by Fe-NTA. Results were analysed by GraphPad®Prism 8.4.2. Analysis of variance (ANOVA) was used to compare several groups. The difference between groups was determined by Tukeyʼs test and considered significant at p<0.05. Results: Hydroalcoholic extract of B. ferruginea increased aPTT and decreased PR. Compared to the negative control (distilled water), oxidative stress was responsible in vivo for an increase in platelets blood number and PR and a decrease in aPTT and fibrinogen. The hydroalcoholic extract of B. ferruginea caused a decrease in platelets blood number (at low concentration), PR and fibrinogen level and an increase in the platelets blood number (at high concentration) and aPTT. Hydroalcoholic extract of B. ferruginea decreased MDA levels and increased GSH levels in rats subjected to oxidative stress. Conclusion: The present study proved existence of antioxidant and anticoagulant activities of B. ferruginea stem bark. There is a link between oxidative stress and coagulation. Future studies may better elucidate interaction between oxidative stress and coagulation mechanisms involved.
| Published in | Journal of Diseases and Medicinal Plants (Volume 8, Issue 2) |
| DOI | 10.11648/j.jdmp.20220802.14 |
| Page(s) | 41-45 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Bridelia ferruginea, Oxidative Stress, Blood Coagulation
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APA Style
Messanh Delagnon Irenee Kueviakoe, Sabrina Chris Janiba Sanvee, Hezouwe Magnang, Komlan Mawubédjro Dossou-Yovo, Aboudoulatif Diallo, et al. (2022). Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation. Journal of Diseases and Medicinal Plants, 8(2), 41-45. https://doi.org/10.11648/j.jdmp.20220802.14
ACS Style
Messanh Delagnon Irenee Kueviakoe; Sabrina Chris Janiba Sanvee; Hezouwe Magnang; Komlan Mawubédjro Dossou-Yovo; Aboudoulatif Diallo, et al. Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation. J. Dis. Med. Plants 2022, 8(2), 41-45. doi: 10.11648/j.jdmp.20220802.14
AMA Style
Messanh Delagnon Irenee Kueviakoe, Sabrina Chris Janiba Sanvee, Hezouwe Magnang, Komlan Mawubédjro Dossou-Yovo, Aboudoulatif Diallo, et al. Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation. J Dis Med Plants. 2022;8(2):41-45. doi: 10.11648/j.jdmp.20220802.14
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Download@article{10.11648/j.jdmp.20220802.14,
author = {Messanh Delagnon Irenee Kueviakoe and Sabrina Chris Janiba Sanvee and Hezouwe Magnang and Komlan Mawubédjro Dossou-Yovo and Aboudoulatif Diallo and Ahoefa Vovor and Kwashie Eklu-Gadegbeku},
title = {Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation},
journal = {Journal of Diseases and Medicinal Plants},
volume = {8},
number = {2},
pages = {41-45},
doi = {10.11648/j.jdmp.20220802.14},
url = {https://doi.org/10.11648/j.jdmp.20220802.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20220802.14},
abstract = {Bridelia ferruginea is a plant commonly used in several regions of the world for its various properties. It is offered to certain patients with cerebrovascular accidents. It is with this in mind that this study is undertaken in order to verify whether B. ferruginea has an activity on blood coagulation. Materiel and method: Stem bark of B. ferruginea was collected at Noepe (24 km northwest of Lome). Hydroalcoholic extract (50/50) was obtained by evaporation. Male Wistar rats were used for the tests. Qualitative screening was done according to conventional methods and total phenols were quantified. Some parameters of coagulation (blood platelets, aPTT, PR and fibrinogen) were determined. Oxidative stress was induced by Fe-NTA. Results were analysed by GraphPad®Prism 8.4.2. Analysis of variance (ANOVA) was used to compare several groups. The difference between groups was determined by Tukeyʼs test and considered significant at pResults: Hydroalcoholic extract of B. ferruginea increased aPTT and decreased PR. Compared to the negative control (distilled water), oxidative stress was responsible in vivo for an increase in platelets blood number and PR and a decrease in aPTT and fibrinogen. The hydroalcoholic extract of B. ferruginea caused a decrease in platelets blood number (at low concentration), PR and fibrinogen level and an increase in the platelets blood number (at high concentration) and aPTT. Hydroalcoholic extract of B. ferruginea decreased MDA levels and increased GSH levels in rats subjected to oxidative stress. Conclusion: The present study proved existence of antioxidant and anticoagulant activities of B. ferruginea stem bark. There is a link between oxidative stress and coagulation. Future studies may better elucidate interaction between oxidative stress and coagulation mechanisms involved.},
year = {2022}
}
TY - JOUR T1 - Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation AU - Messanh Delagnon Irenee Kueviakoe AU - Sabrina Chris Janiba Sanvee AU - Hezouwe Magnang AU - Komlan Mawubédjro Dossou-Yovo AU - Aboudoulatif Diallo AU - Ahoefa Vovor AU - Kwashie Eklu-Gadegbeku Y1 - 2022/05/24 PY - 2022 N1 - https://doi.org/10.11648/j.jdmp.20220802.14 DO - 10.11648/j.jdmp.20220802.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 41 EP - 45 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20220802.14 AB - Bridelia ferruginea is a plant commonly used in several regions of the world for its various properties. It is offered to certain patients with cerebrovascular accidents. It is with this in mind that this study is undertaken in order to verify whether B. ferruginea has an activity on blood coagulation. Materiel and method: Stem bark of B. ferruginea was collected at Noepe (24 km northwest of Lome). Hydroalcoholic extract (50/50) was obtained by evaporation. Male Wistar rats were used for the tests. Qualitative screening was done according to conventional methods and total phenols were quantified. Some parameters of coagulation (blood platelets, aPTT, PR and fibrinogen) were determined. Oxidative stress was induced by Fe-NTA. Results were analysed by GraphPad®Prism 8.4.2. Analysis of variance (ANOVA) was used to compare several groups. The difference between groups was determined by Tukeyʼs test and considered significant at pResults: Hydroalcoholic extract of B. ferruginea increased aPTT and decreased PR. Compared to the negative control (distilled water), oxidative stress was responsible in vivo for an increase in platelets blood number and PR and a decrease in aPTT and fibrinogen. The hydroalcoholic extract of B. ferruginea caused a decrease in platelets blood number (at low concentration), PR and fibrinogen level and an increase in the platelets blood number (at high concentration) and aPTT. Hydroalcoholic extract of B. ferruginea decreased MDA levels and increased GSH levels in rats subjected to oxidative stress. Conclusion: The present study proved existence of antioxidant and anticoagulant activities of B. ferruginea stem bark. There is a link between oxidative stress and coagulation. Future studies may better elucidate interaction between oxidative stress and coagulation mechanisms involved. VL - 8 IS - 2 ER -
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