Remnant Indices for Estimating Postprandial Lipidemia in Young Women

Erika Mizutani-Watanabe; Michitaka Naito

doi:doi:10.11648/j.ijnfs.20231201.13

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Remnant Indices for Estimating Postprandial Lipidemia in Young Women

Erika Mizutani-Watanabe, Michitaka Naito

Published in International Journal of Nutrition and Food Sciences (Volume 12, Issue 1)

Received: 25 January 2023 Accepted: 14 February 2023 Published: 24 February 2023

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Abstract

Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, for postprandial hyperlipidemia, no definitive criteria exist, and fasting values of lipids and lipoproteins had limited efficacy for estimating postprandial lipidemia. In the present study, we performed a fat-ingestion test and aimed to propose indices for estimating postprandial lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum triglyceride (TG) level peaked at 2 h and returned to below baseline at 6 h. The remnant-like particle-TG (RP-TG) level increased at 1 h, peaked at 2 h, and returned to baseline at 6 h. The remnant lipoprotein-cholesterol (RLP-C) level increased at 2 h, peaked at 4 h, and returned to baseline at 6 h. The apolipoprotein B48 level increased at 1 h, peaked at 4 h, and did not return to baseline at 6 h. The apolipoprotein B100 concentration slightly decreased at 2 h and increased at 6 h. TG−RP-TG did not change during 6 h, but RP-TG/TG rose at 2–6 h compared to the fasting value. RP-TG/RLP-C increased at 2–4 h and returned to baseline at 6 h. Conclusion: After fat ingestion, while the concentration of non-remnant TG was stable, remnant TG increased. The content of TG per remnant particle increased up to 2 h and decreased from 2 h to 6 h, and the size became smaller. The remnant indices, RP-TG/TG and RP-TG/RLP-C, may be useful for estimating postprandial lipidemia.

Published in	International Journal of Nutrition and Food Sciences (Volume 12, Issue 1)
DOI	10.11648/j.ijnfs.20231201.13
Page(s)	21-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fat-Ingestion Test, Postprandial Lipidemia, Remnant, Index, Women, Apolipoprotein B48, Triglyceride

References

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APA Style

Erika Mizutani-Watanabe, Michitaka Naito. (2023). Remnant Indices for Estimating Postprandial Lipidemia in Young Women. International Journal of Nutrition and Food Sciences, 12(1), 21-28. https://doi.org/10.11648/j.ijnfs.20231201.13

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ACS Style

Erika Mizutani-Watanabe; Michitaka Naito. Remnant Indices for Estimating Postprandial Lipidemia in Young Women. Int. J. Nutr. Food Sci. 2023, 12(1), 21-28. doi: 10.11648/j.ijnfs.20231201.13

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AMA Style

Erika Mizutani-Watanabe, Michitaka Naito. Remnant Indices for Estimating Postprandial Lipidemia in Young Women. Int J Nutr Food Sci. 2023;12(1):21-28. doi: 10.11648/j.ijnfs.20231201.13

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@article{10.11648/j.ijnfs.20231201.13,
  author = {Erika Mizutani-Watanabe and Michitaka Naito},
  title = {Remnant Indices for Estimating Postprandial Lipidemia in Young Women},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {12},
  number = {1},
  pages = {21-28},
  doi = {10.11648/j.ijnfs.20231201.13},
  url = {https://doi.org/10.11648/j.ijnfs.20231201.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20231201.13},
  abstract = {Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, for postprandial hyperlipidemia, no definitive criteria exist, and fasting values of lipids and lipoproteins had limited efficacy for estimating postprandial lipidemia. In the present study, we performed a fat-ingestion test and aimed to propose indices for estimating postprandial lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum triglyceride (TG) level peaked at 2 h and returned to below baseline at 6 h. The remnant-like particle-TG (RP-TG) level increased at 1 h, peaked at 2 h, and returned to baseline at 6 h. The remnant lipoprotein-cholesterol (RLP-C) level increased at 2 h, peaked at 4 h, and returned to baseline at 6 h. The apolipoprotein B48 level increased at 1 h, peaked at 4 h, and did not return to baseline at 6 h. The apolipoprotein B100 concentration slightly decreased at 2 h and increased at 6 h. TG−RP-TG did not change during 6 h, but RP-TG/TG rose at 2–6 h compared to the fasting value. RP-TG/RLP-C increased at 2–4 h and returned to baseline at 6 h. Conclusion: After fat ingestion, while the concentration of non-remnant TG was stable, remnant TG increased. The content of TG per remnant particle increased up to 2 h and decreased from 2 h to 6 h, and the size became smaller. The remnant indices, RP-TG/TG and RP-TG/RLP-C, may be useful for estimating postprandial lipidemia.},
 year = {2023}
}

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TY  - JOUR
T1  - Remnant Indices for Estimating Postprandial Lipidemia in Young Women
AU  - Erika Mizutani-Watanabe
AU  - Michitaka Naito
Y1  - 2023/02/24
PY  - 2023
N1  - https://doi.org/10.11648/j.ijnfs.20231201.13
DO  - 10.11648/j.ijnfs.20231201.13
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 21
EP  - 28
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20231201.13
AB  - Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, for postprandial hyperlipidemia, no definitive criteria exist, and fasting values of lipids and lipoproteins had limited efficacy for estimating postprandial lipidemia. In the present study, we performed a fat-ingestion test and aimed to propose indices for estimating postprandial lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum triglyceride (TG) level peaked at 2 h and returned to below baseline at 6 h. The remnant-like particle-TG (RP-TG) level increased at 1 h, peaked at 2 h, and returned to baseline at 6 h. The remnant lipoprotein-cholesterol (RLP-C) level increased at 2 h, peaked at 4 h, and returned to baseline at 6 h. The apolipoprotein B48 level increased at 1 h, peaked at 4 h, and did not return to baseline at 6 h. The apolipoprotein B100 concentration slightly decreased at 2 h and increased at 6 h. TG−RP-TG did not change during 6 h, but RP-TG/TG rose at 2–6 h compared to the fasting value. RP-TG/RLP-C increased at 2–4 h and returned to baseline at 6 h. Conclusion: After fat ingestion, while the concentration of non-remnant TG was stable, remnant TG increased. The content of TG per remnant particle increased up to 2 h and decreased from 2 h to 6 h, and the size became smaller. The remnant indices, RP-TG/TG and RP-TG/RLP-C, may be useful for estimating postprandial lipidemia.
VL  - 12
IS  - 1
ER  -

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Author Information

Erika Mizutani-Watanabe

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Michitaka Naito

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

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Erika Mizutani-Watanabe, Michitaka Naito. (2023). Remnant Indices for Estimating Postprandial Lipidemia in Young Women. International Journal of Nutrition and Food Sciences, 12(1), 21-28. https://doi.org/10.11648/j.ijnfs.20231201.13

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ACS Style

Erika Mizutani-Watanabe; Michitaka Naito. Remnant Indices for Estimating Postprandial Lipidemia in Young Women. Int. J. Nutr. Food Sci. 2023, 12(1), 21-28. doi: 10.11648/j.ijnfs.20231201.13

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AMA Style

Erika Mizutani-Watanabe, Michitaka Naito. Remnant Indices for Estimating Postprandial Lipidemia in Young Women. Int J Nutr Food Sci. 2023;12(1):21-28. doi: 10.11648/j.ijnfs.20231201.13

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@article{10.11648/j.ijnfs.20231201.13,
  author = {Erika Mizutani-Watanabe and Michitaka Naito},
  title = {Remnant Indices for Estimating Postprandial Lipidemia in Young Women},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {12},
  number = {1},
  pages = {21-28},
  doi = {10.11648/j.ijnfs.20231201.13},
  url = {https://doi.org/10.11648/j.ijnfs.20231201.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20231201.13},
  abstract = {Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, for postprandial hyperlipidemia, no definitive criteria exist, and fasting values of lipids and lipoproteins had limited efficacy for estimating postprandial lipidemia. In the present study, we performed a fat-ingestion test and aimed to propose indices for estimating postprandial lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum triglyceride (TG) level peaked at 2 h and returned to below baseline at 6 h. The remnant-like particle-TG (RP-TG) level increased at 1 h, peaked at 2 h, and returned to baseline at 6 h. The remnant lipoprotein-cholesterol (RLP-C) level increased at 2 h, peaked at 4 h, and returned to baseline at 6 h. The apolipoprotein B48 level increased at 1 h, peaked at 4 h, and did not return to baseline at 6 h. The apolipoprotein B100 concentration slightly decreased at 2 h and increased at 6 h. TG−RP-TG did not change during 6 h, but RP-TG/TG rose at 2–6 h compared to the fasting value. RP-TG/RLP-C increased at 2–4 h and returned to baseline at 6 h. Conclusion: After fat ingestion, while the concentration of non-remnant TG was stable, remnant TG increased. The content of TG per remnant particle increased up to 2 h and decreased from 2 h to 6 h, and the size became smaller. The remnant indices, RP-TG/TG and RP-TG/RLP-C, may be useful for estimating postprandial lipidemia.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Remnant Indices for Estimating Postprandial Lipidemia in Young Women
AU  - Erika Mizutani-Watanabe
AU  - Michitaka Naito
Y1  - 2023/02/24
PY  - 2023
N1  - https://doi.org/10.11648/j.ijnfs.20231201.13
DO  - 10.11648/j.ijnfs.20231201.13
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 21
EP  - 28
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20231201.13
AB  - Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, for postprandial hyperlipidemia, no definitive criteria exist, and fasting values of lipids and lipoproteins had limited efficacy for estimating postprandial lipidemia. In the present study, we performed a fat-ingestion test and aimed to propose indices for estimating postprandial lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum triglyceride (TG) level peaked at 2 h and returned to below baseline at 6 h. The remnant-like particle-TG (RP-TG) level increased at 1 h, peaked at 2 h, and returned to baseline at 6 h. The remnant lipoprotein-cholesterol (RLP-C) level increased at 2 h, peaked at 4 h, and returned to baseline at 6 h. The apolipoprotein B48 level increased at 1 h, peaked at 4 h, and did not return to baseline at 6 h. The apolipoprotein B100 concentration slightly decreased at 2 h and increased at 6 h. TG−RP-TG did not change during 6 h, but RP-TG/TG rose at 2–6 h compared to the fasting value. RP-TG/RLP-C increased at 2–4 h and returned to baseline at 6 h. Conclusion: After fat ingestion, while the concentration of non-remnant TG was stable, remnant TG increased. The content of TG per remnant particle increased up to 2 h and decreased from 2 h to 6 h, and the size became smaller. The remnant indices, RP-TG/TG and RP-TG/RLP-C, may be useful for estimating postprandial lipidemia.
VL  - 12
IS  - 1
ER  -

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