Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy

Lobna Abd-El Aziz Shkeban; Samah Ahmed Radwan; Ashraf Ali Abo-el-Safa; Hanan Mohamed Saleh El-Ahwal

doi:doi:10.11648/j.ijmi.20210904.11

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Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy

Lobna Abd-El Aziz Shkeban, Samah Ahmed Radwan, Ashraf Ali Abo-el-Safa, Hanan Mohamed Saleh El-Ahwal

Published in International Journal of Medical Imaging (Volume 9, Issue 4)

Received: 12 September 2021 Accepted: 8 October 2021 Published: 16 October 2021

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Abstract

Background: Epilepsies are one of the most prevalent neurological disorders. Notably, magnetic resonance (MR) tractography based on diffusion-tensor imaging (DTI) is heavily used in clinical diagnostic studies to detect small anomalies encompassing the lesion identified on conventional magnetic resonance imaging (MRI) and appearing normal-looking white matter (WM). This study aimed to determine the added value of diffusion tensor MRI and tractography in the preoperative assessment of epileptogenic focus. Methods: This prospective study enrolled twenty patients with clinical symptoms of epilepsy and ten healthy control subjects who were age and sex matched. All patients were subjected to the followings: informed consent obtained from all patients, full clinical history taking, neurological examination, Electroencephalography (EEG), conventional MRI, as well as DTI and tractography. Results: The mean fractional anisotropy (FA) values were significantly lower in the studied patients than in the healthy control subjects at both arcuate fasciculi, at both inferior longitudinal fasciculi. Also, the mean FA values had no significant difference between the studied patients and the controls at both cingulum tracts and at both uncinate fasciculi. The same findings were also observed at both corticospinal tracts (CSTs). There was a significant correlation between the conventional MRI and DTI in the accuracy in lateralization of the cause of epileptogenic activity in the studied patients. Conclusions: DTI is very helpful tool in providing insights on epileptic seizures, prognosis as well as the correct preoperative planning. DTI with 3D tractographic reconstruction of WM tracts are the only methods that allow the calculation as well as visualization of fiber tracts.

Published in	International Journal of Medical Imaging (Volume 9, Issue 4)
DOI	10.11648/j.ijmi.20210904.11
Page(s)	159-166
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Magnetic Resonance, Tractography, Epilepsy

References

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APA Style

Lobna Abd-El Aziz Shkeban, Samah Ahmed Radwan, Ashraf Ali Abo-el-Safa, Hanan Mohamed Saleh El-Ahwal. (2021). Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. International Journal of Medical Imaging, 9(4), 159-166. https://doi.org/10.11648/j.ijmi.20210904.11

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ACS Style

Lobna Abd-El Aziz Shkeban; Samah Ahmed Radwan; Ashraf Ali Abo-el-Safa; Hanan Mohamed Saleh El-Ahwal. Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. Int. J. Med. Imaging 2021, 9(4), 159-166. doi: 10.11648/j.ijmi.20210904.11

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AMA Style

Lobna Abd-El Aziz Shkeban, Samah Ahmed Radwan, Ashraf Ali Abo-el-Safa, Hanan Mohamed Saleh El-Ahwal. Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. Int J Med Imaging. 2021;9(4):159-166. doi: 10.11648/j.ijmi.20210904.11

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@article{10.11648/j.ijmi.20210904.11,
  author = {Lobna Abd-El Aziz Shkeban and Samah Ahmed Radwan and Ashraf Ali Abo-el-Safa and Hanan Mohamed Saleh El-Ahwal},
  title = {Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy},
  journal = {International Journal of Medical Imaging},
  volume = {9},
  number = {4},
  pages = {159-166},
  doi = {10.11648/j.ijmi.20210904.11},
  url = {https://doi.org/10.11648/j.ijmi.20210904.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20210904.11},
  abstract = {Background: Epilepsies are one of the most prevalent neurological disorders. Notably, magnetic resonance (MR) tractography based on diffusion-tensor imaging (DTI) is heavily used in clinical diagnostic studies to detect small anomalies encompassing the lesion identified on conventional magnetic resonance imaging (MRI) and appearing normal-looking white matter (WM). This study aimed to determine the added value of diffusion tensor MRI and tractography in the preoperative assessment of epileptogenic focus. Methods: This prospective study enrolled twenty patients with clinical symptoms of epilepsy and ten healthy control subjects who were age and sex matched. All patients were subjected to the followings: informed consent obtained from all patients, full clinical history taking, neurological examination, Electroencephalography (EEG), conventional MRI, as well as DTI and tractography. Results: The mean fractional anisotropy (FA) values were significantly lower in the studied patients than in the healthy control subjects at both arcuate fasciculi, at both inferior longitudinal fasciculi. Also, the mean FA values had no significant difference between the studied patients and the controls at both cingulum tracts and at both uncinate fasciculi. The same findings were also observed at both corticospinal tracts (CSTs). There was a significant correlation between the conventional MRI and DTI in the accuracy in lateralization of the cause of epileptogenic activity in the studied patients. Conclusions: DTI is very helpful tool in providing insights on epileptic seizures, prognosis as well as the correct preoperative planning. DTI with 3D tractographic reconstruction of WM tracts are the only methods that allow the calculation as well as visualization of fiber tracts.},
 year = {2021}
}

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TY  - JOUR
T1  - Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy
AU  - Lobna Abd-El Aziz Shkeban
AU  - Samah Ahmed Radwan
AU  - Ashraf Ali Abo-el-Safa
AU  - Hanan Mohamed Saleh El-Ahwal
Y1  - 2021/10/16
PY  - 2021
N1  - https://doi.org/10.11648/j.ijmi.20210904.11
DO  - 10.11648/j.ijmi.20210904.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 159
EP  - 166
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20210904.11
AB  - Background: Epilepsies are one of the most prevalent neurological disorders. Notably, magnetic resonance (MR) tractography based on diffusion-tensor imaging (DTI) is heavily used in clinical diagnostic studies to detect small anomalies encompassing the lesion identified on conventional magnetic resonance imaging (MRI) and appearing normal-looking white matter (WM). This study aimed to determine the added value of diffusion tensor MRI and tractography in the preoperative assessment of epileptogenic focus. Methods: This prospective study enrolled twenty patients with clinical symptoms of epilepsy and ten healthy control subjects who were age and sex matched. All patients were subjected to the followings: informed consent obtained from all patients, full clinical history taking, neurological examination, Electroencephalography (EEG), conventional MRI, as well as DTI and tractography. Results: The mean fractional anisotropy (FA) values were significantly lower in the studied patients than in the healthy control subjects at both arcuate fasciculi, at both inferior longitudinal fasciculi. Also, the mean FA values had no significant difference between the studied patients and the controls at both cingulum tracts and at both uncinate fasciculi. The same findings were also observed at both corticospinal tracts (CSTs). There was a significant correlation between the conventional MRI and DTI in the accuracy in lateralization of the cause of epileptogenic activity in the studied patients. Conclusions: DTI is very helpful tool in providing insights on epileptic seizures, prognosis as well as the correct preoperative planning. DTI with 3D tractographic reconstruction of WM tracts are the only methods that allow the calculation as well as visualization of fiber tracts.
VL  - 9
IS  - 4
ER  -

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Author Information

Lobna Abd-El Aziz Shkeban

Radiology Department, El Obour Hospital for Health Insurance, General Authority for Health Insurance, Kafrelsheikh, Egypt
Samah Ahmed Radwan

Radiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Ashraf Ali Abo-el-Safa

Neuropsychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Hanan Mohamed Saleh El-Ahwal

Radiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

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APA Style

Lobna Abd-El Aziz Shkeban, Samah Ahmed Radwan, Ashraf Ali Abo-el-Safa, Hanan Mohamed Saleh El-Ahwal. (2021). Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. International Journal of Medical Imaging, 9(4), 159-166. https://doi.org/10.11648/j.ijmi.20210904.11

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ACS Style

Lobna Abd-El Aziz Shkeban; Samah Ahmed Radwan; Ashraf Ali Abo-el-Safa; Hanan Mohamed Saleh El-Ahwal. Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. Int. J. Med. Imaging 2021, 9(4), 159-166. doi: 10.11648/j.ijmi.20210904.11

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AMA Style

Lobna Abd-El Aziz Shkeban, Samah Ahmed Radwan, Ashraf Ali Abo-el-Safa, Hanan Mohamed Saleh El-Ahwal. Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy. Int J Med Imaging. 2021;9(4):159-166. doi: 10.11648/j.ijmi.20210904.11

Copy | Download

@article{10.11648/j.ijmi.20210904.11,
  author = {Lobna Abd-El Aziz Shkeban and Samah Ahmed Radwan and Ashraf Ali Abo-el-Safa and Hanan Mohamed Saleh El-Ahwal},
  title = {Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy},
  journal = {International Journal of Medical Imaging},
  volume = {9},
  number = {4},
  pages = {159-166},
  doi = {10.11648/j.ijmi.20210904.11},
  url = {https://doi.org/10.11648/j.ijmi.20210904.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20210904.11},
  abstract = {Background: Epilepsies are one of the most prevalent neurological disorders. Notably, magnetic resonance (MR) tractography based on diffusion-tensor imaging (DTI) is heavily used in clinical diagnostic studies to detect small anomalies encompassing the lesion identified on conventional magnetic resonance imaging (MRI) and appearing normal-looking white matter (WM). This study aimed to determine the added value of diffusion tensor MRI and tractography in the preoperative assessment of epileptogenic focus. Methods: This prospective study enrolled twenty patients with clinical symptoms of epilepsy and ten healthy control subjects who were age and sex matched. All patients were subjected to the followings: informed consent obtained from all patients, full clinical history taking, neurological examination, Electroencephalography (EEG), conventional MRI, as well as DTI and tractography. Results: The mean fractional anisotropy (FA) values were significantly lower in the studied patients than in the healthy control subjects at both arcuate fasciculi, at both inferior longitudinal fasciculi. Also, the mean FA values had no significant difference between the studied patients and the controls at both cingulum tracts and at both uncinate fasciculi. The same findings were also observed at both corticospinal tracts (CSTs). There was a significant correlation between the conventional MRI and DTI in the accuracy in lateralization of the cause of epileptogenic activity in the studied patients. Conclusions: DTI is very helpful tool in providing insights on epileptic seizures, prognosis as well as the correct preoperative planning. DTI with 3D tractographic reconstruction of WM tracts are the only methods that allow the calculation as well as visualization of fiber tracts.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Diffusion-Based Magnetic Resonance and Tractography in Assessment of Patients with Epilepsy
AU  - Lobna Abd-El Aziz Shkeban
AU  - Samah Ahmed Radwan
AU  - Ashraf Ali Abo-el-Safa
AU  - Hanan Mohamed Saleh El-Ahwal
Y1  - 2021/10/16
PY  - 2021
N1  - https://doi.org/10.11648/j.ijmi.20210904.11
DO  - 10.11648/j.ijmi.20210904.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 159
EP  - 166
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20210904.11
AB  - Background: Epilepsies are one of the most prevalent neurological disorders. Notably, magnetic resonance (MR) tractography based on diffusion-tensor imaging (DTI) is heavily used in clinical diagnostic studies to detect small anomalies encompassing the lesion identified on conventional magnetic resonance imaging (MRI) and appearing normal-looking white matter (WM). This study aimed to determine the added value of diffusion tensor MRI and tractography in the preoperative assessment of epileptogenic focus. Methods: This prospective study enrolled twenty patients with clinical symptoms of epilepsy and ten healthy control subjects who were age and sex matched. All patients were subjected to the followings: informed consent obtained from all patients, full clinical history taking, neurological examination, Electroencephalography (EEG), conventional MRI, as well as DTI and tractography. Results: The mean fractional anisotropy (FA) values were significantly lower in the studied patients than in the healthy control subjects at both arcuate fasciculi, at both inferior longitudinal fasciculi. Also, the mean FA values had no significant difference between the studied patients and the controls at both cingulum tracts and at both uncinate fasciculi. The same findings were also observed at both corticospinal tracts (CSTs). There was a significant correlation between the conventional MRI and DTI in the accuracy in lateralization of the cause of epileptogenic activity in the studied patients. Conclusions: DTI is very helpful tool in providing insights on epileptic seizures, prognosis as well as the correct preoperative planning. DTI with 3D tractographic reconstruction of WM tracts are the only methods that allow the calculation as well as visualization of fiber tracts.
VL  - 9
IS  - 4
ER  -

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