Introduction: Matrix metalloproteinase (MMP)-2 is a member of MMPs family which is zinc-dependent endopeptidases that degrade all components of ECM and vascular basement membrane. MMPs are closely involved in tumor invasion and metastasis. Aim of the work: is to evaluate the immune-expression and clinical significance of MMPs molecule in patients with pancreatic carcinoma. Materials and Methods: A total of 25 pancreatic carcinomas were evaluated for expression of MMP-2 by immunohistochemical technique. The expression was evaluated. The study included 24/25 cases of PDAC and 1/25 acinar cell carcinoma. PDAC included 5/24 cases of well differentiated, 16/24 cases of moderately differentiated, 3/24 cases of poorly differentiated adenocarcinoma. Results: Pancreatic carcinoma specimens showed positive cytoplasmic MMP-2 staining with high expression in 88% of studied specimens as their IRS ranged from 6/9 to 9/9 with high extent and intensity. There was a statistically significant relationship between MMP-2 expression and high grade in PDAC (p<0.024). Conclusion: MMP-2 was expressed in PDAC and not in pancreatitis cases. The expression of MMP-2 was correlated with high histological grade and poor prognosis in PDAC.
| Published in | International Journal of Immunology (Volume 9, Issue 3) |
| DOI | 10.11648/j.iji.20210903.12 |
| Page(s) | 47-53 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
(MMP-2) Matrix Metalloproteinases, (PDAC) Pancreatic Duct Adenocarcinoma, Immunohistochemistry, ECM Extracellular Matrix
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APA Style
Afaf Taha El-Nashar, Eman Muhammad Salah Muhammad, Mohammed Hamdy Sayed, Said Abuel-kheer Mohammed. (2021). Immunohistochemical Expression of MMP-2 in Pancreatic Carcinoma and Chronic Pancreatitis. International Journal of Immunology, 9(3), 47-53. https://doi.org/10.11648/j.iji.20210903.12
ACS Style
Afaf Taha El-Nashar; Eman Muhammad Salah Muhammad; Mohammed Hamdy Sayed; Said Abuel-kheer Mohammed. Immunohistochemical Expression of MMP-2 in Pancreatic Carcinoma and Chronic Pancreatitis. Int. J. Immunol. 2021, 9(3), 47-53. doi: 10.11648/j.iji.20210903.12
AMA Style
Afaf Taha El-Nashar, Eman Muhammad Salah Muhammad, Mohammed Hamdy Sayed, Said Abuel-kheer Mohammed. Immunohistochemical Expression of MMP-2 in Pancreatic Carcinoma and Chronic Pancreatitis. Int J Immunol. 2021;9(3):47-53. doi: 10.11648/j.iji.20210903.12
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Download@article{10.11648/j.iji.20210903.12,
author = {Afaf Taha El-Nashar and Eman Muhammad Salah Muhammad and Mohammed Hamdy Sayed and Said Abuel-kheer Mohammed},
title = {Immunohistochemical Expression of MMP-2 in Pancreatic Carcinoma and Chronic Pancreatitis},
journal = {International Journal of Immunology},
volume = {9},
number = {3},
pages = {47-53},
doi = {10.11648/j.iji.20210903.12},
url = {https://doi.org/10.11648/j.iji.20210903.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210903.12},
abstract = {Introduction: Matrix metalloproteinase (MMP)-2 is a member of MMPs family which is zinc-dependent endopeptidases that degrade all components of ECM and vascular basement membrane. MMPs are closely involved in tumor invasion and metastasis. Aim of the work: is to evaluate the immune-expression and clinical significance of MMPs molecule in patients with pancreatic carcinoma. Materials and Methods: A total of 25 pancreatic carcinomas were evaluated for expression of MMP-2 by immunohistochemical technique. The expression was evaluated. The study included 24/25 cases of PDAC and 1/25 acinar cell carcinoma. PDAC included 5/24 cases of well differentiated, 16/24 cases of moderately differentiated, 3/24 cases of poorly differentiated adenocarcinoma. Results: Pancreatic carcinoma specimens showed positive cytoplasmic MMP-2 staining with high expression in 88% of studied specimens as their IRS ranged from 6/9 to 9/9 with high extent and intensity. There was a statistically significant relationship between MMP-2 expression and high grade in PDAC (pConclusion: MMP-2 was expressed in PDAC and not in pancreatitis cases. The expression of MMP-2 was correlated with high histological grade and poor prognosis in PDAC.},
year = {2021}
}
TY - JOUR T1 - Immunohistochemical Expression of MMP-2 in Pancreatic Carcinoma and Chronic Pancreatitis AU - Afaf Taha El-Nashar AU - Eman Muhammad Salah Muhammad AU - Mohammed Hamdy Sayed AU - Said Abuel-kheer Mohammed Y1 - 2021/08/19 PY - 2021 N1 - https://doi.org/10.11648/j.iji.20210903.12 DO - 10.11648/j.iji.20210903.12 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 47 EP - 53 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20210903.12 AB - Introduction: Matrix metalloproteinase (MMP)-2 is a member of MMPs family which is zinc-dependent endopeptidases that degrade all components of ECM and vascular basement membrane. MMPs are closely involved in tumor invasion and metastasis. Aim of the work: is to evaluate the immune-expression and clinical significance of MMPs molecule in patients with pancreatic carcinoma. Materials and Methods: A total of 25 pancreatic carcinomas were evaluated for expression of MMP-2 by immunohistochemical technique. The expression was evaluated. The study included 24/25 cases of PDAC and 1/25 acinar cell carcinoma. PDAC included 5/24 cases of well differentiated, 16/24 cases of moderately differentiated, 3/24 cases of poorly differentiated adenocarcinoma. Results: Pancreatic carcinoma specimens showed positive cytoplasmic MMP-2 staining with high expression in 88% of studied specimens as their IRS ranged from 6/9 to 9/9 with high extent and intensity. There was a statistically significant relationship between MMP-2 expression and high grade in PDAC (pConclusion: MMP-2 was expressed in PDAC and not in pancreatitis cases. The expression of MMP-2 was correlated with high histological grade and poor prognosis in PDAC. VL - 9 IS - 3 ER -
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