Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis

Lingling Li; Qianwen Li; Junhao Wang; Hao Wang; Yongjuan Xin; Shenshen Zhang; Ying Cao; Mengyao Zhou; Wenjie Yang

doi:doi:10.11648/j.ijde.20210601.17

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Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis

Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, Shenshen Zhang, Ying Cao, Mengyao Zhou, Wenjie Yang

Published in International Journal of Diabetes and Endocrinology (Volume 6, Issue 1)

Received: 2 February 2021 Accepted: 15 February 2021 Published: 4 March 2021

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Abstract

Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.

Published in	International Journal of Diabetes and Endocrinology (Volume 6, Issue 1)
DOI	10.11648/j.ijde.20210601.17
Page(s)	36-45
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Calcium, Vitamin D, Type 2 Diabetes Mellitus, Meta-analysis

References

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APA Style

Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, et al. (2021). Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. International Journal of Diabetes and Endocrinology, 6(1), 36-45. https://doi.org/10.11648/j.ijde.20210601.17

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ACS Style

Lingling Li; Qianwen Li; Junhao Wang; Hao Wang; Yongjuan Xin, et al. Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. Int. J. Diabetes Endocrinol. 2021, 6(1), 36-45. doi: 10.11648/j.ijde.20210601.17

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AMA Style

Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, et al. Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. Int J Diabetes Endocrinol. 2021;6(1):36-45. doi: 10.11648/j.ijde.20210601.17

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@article{10.11648/j.ijde.20210601.17,
  author = {Lingling Li and Qianwen Li and Junhao Wang and Hao Wang and Yongjuan Xin and Shenshen Zhang and Ying Cao and Mengyao Zhou and Wenjie Yang},
  title = {Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {1},
  pages = {36-45},
  doi = {10.11648/j.ijde.20210601.17},
  url = {https://doi.org/10.11648/j.ijde.20210601.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210601.17},
  abstract = {Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.},
 year = {2021}
}

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TY  - JOUR
T1  - Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis
AU  - Lingling Li
AU  - Qianwen Li
AU  - Junhao Wang
AU  - Hao Wang
AU  - Yongjuan Xin
AU  - Shenshen Zhang
AU  - Ying Cao
AU  - Mengyao Zhou
AU  - Wenjie Yang
Y1  - 2021/03/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210601.17
DO  - 10.11648/j.ijde.20210601.17
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 36
EP  - 45
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210601.17
AB  - Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.
VL  - 6
IS  - 1
ER  -

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Author Information

Lingling Li

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Qianwen Li

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Junhao Wang

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Hao Wang

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Yongjuan Xin

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Shenshen Zhang

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Ying Cao

School of Education and Child Development, Drury University, Springfield, Missouri, USA
Mengyao Zhou

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China
Wenjie Yang

Precision Nutrition Innovation Center, Department of Nutrition, College of Public Health, Zhengzhou University, Zhengzhou, China

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APA Style

Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, et al. (2021). Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. International Journal of Diabetes and Endocrinology, 6(1), 36-45. https://doi.org/10.11648/j.ijde.20210601.17

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ACS Style

Lingling Li; Qianwen Li; Junhao Wang; Hao Wang; Yongjuan Xin, et al. Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. Int. J. Diabetes Endocrinol. 2021, 6(1), 36-45. doi: 10.11648/j.ijde.20210601.17

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AMA Style

Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, et al. Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis. Int J Diabetes Endocrinol. 2021;6(1):36-45. doi: 10.11648/j.ijde.20210601.17

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@article{10.11648/j.ijde.20210601.17,
  author = {Lingling Li and Qianwen Li and Junhao Wang and Hao Wang and Yongjuan Xin and Shenshen Zhang and Ying Cao and Mengyao Zhou and Wenjie Yang},
  title = {Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {1},
  pages = {36-45},
  doi = {10.11648/j.ijde.20210601.17},
  url = {https://doi.org/10.11648/j.ijde.20210601.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210601.17},
  abstract = {Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis
AU  - Lingling Li
AU  - Qianwen Li
AU  - Junhao Wang
AU  - Hao Wang
AU  - Yongjuan Xin
AU  - Shenshen Zhang
AU  - Ying Cao
AU  - Mengyao Zhou
AU  - Wenjie Yang
Y1  - 2021/03/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210601.17
DO  - 10.11648/j.ijde.20210601.17
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 36
EP  - 45
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210601.17
AB  - Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.
VL  - 6
IS  - 1
ER  -

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